10 20
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40 50
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70 80
90
100
110
120
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structures
|-Motif 1| |-2|
Homo sapiens
RLRFIPKPDG--LRPIVNMDYVVGARTFRRE-----------------------------------------------------------------------------------------
Mesocricetus auratus RLRFIPKPSG--LRPIVNMSY-MGTRAFDKG-----------------------------------------------------------------------------------------
Mus musculus
RLRFIPKPNG--LRPIVNMSYSMGTRALGRR-----------------------------------------------------------------------------------------
Rattus norvegicus RLRFIPKLNG--LRPIVNMSYGMDTRAFGKK-----------------------------------------------------------------------------------------
Canis familiaris
RLRFLPKPSG--LRPIVNMDYIMGARTFHRD-----------------------------------------------------------------------------------------
Bos taurus
RLRFVPKPGG--LRPIVNVGCVEGAPAPPRD-----------------------------------------------------------------------------------------
Coturnix japonica RLRFIPKING--LRPIVRLSRVVEGQKLSKESRE--------------------------------------------------------------------------------------
Gallus gallus
RLRFIPKMNG--LRPVVRLSRVVEGQKLSKESRE--------------------------------------------------------------------------------------
Xenopus laevis
RLRFIPKTNG--LRPISKISSTLSSQ-QSKENQE--------------------------------------------------------------------------------------
Oryzias latipes
QLRFIPKTDG--MRPIT--------RVIGAD-----------------------------------------------------------------------------------------
Oryzias melastigma QLRFIPKADG--MRPIT--------RVIRAD-----------------------------------------------------------------------------------------
Epinephelus coioides RLRFIPKTDG--MRPIT--------RVVGAD-----------------------------------------------------------------------------------------
Takifugu rubripes RLRFIPKTDG--MRPIT--------RVIGAD-----------------------------------------------------------------------------------------
Danio rerio
RIRFIPKTSS--MRPIT--------RLSGSR-----------------------------------------------------------------------------------------
Ciona intestinalis SVRFCPKVNG--LRPIMRLRN---------------------------------------------------------------------------------------------------
Ciona savignyi
AVRFCPKLNG--LRPIMKLRN---------------------------------------------------------------------------------------------------
Apis mellifera
IYKLLCKYSD--VRPIFKLKK---------------------------------------------------------------------------------------------------
Bombyx mori
KLHLVLKPNY-DCRPIVKYRNDE-------------------------------------------------------------------------------------------------
Bombyx mandarina
KLHLVLKPNY-DCRPIVKYRNDE-------------------------------------------------------------------------------------------------
Tribolium castaneum VLNIIPKQDN--FRAIVSIFP---------------------------------------------------------------------------------------------------
Caenorhabditis elegans TFKLSISRQK--LRPLFKR-----------------------------------------------------------------------------------------------------
Caenorhabditis remanei RLKFDIVENK--FRPIIRR-----------------------------------------------------------------------------------------------------
Schizosaccharomyces pombe VIRLLPKKNT--FRLITNLRKRFLIKQMGSN-----------------------------------------------------------------------------------------
Saccharomyces cerevisiae KMRIIPKKSNNEFRIIAIPCRG--------------------------------------------------------------------------------------------------
Saccharomyces kudriavzevii RMRIIPKKSNNEFRIIAIPCEG--------------------------------------------------------------------------------------------------
Saccharomyces bayanus RMRIIPKKSNNEFRIIAIPCRG--------------------------------------------------------------------------------------------------
Saccharomyces paradoxus KMRIIPKKNNNEFRIIAIPCGG--------------------------------------------------------------------------------------------------
Saccharomyces mikatae RMRVIPKKSNNEFRIIAIPCGG--------------------------------------------------------------------------------------------------
Kluyveromyces lactis NLRLIPKKSGLDFRIIAVPCKG--------------------------------------------------------------------------------------------------
Candida albicans 1 KIKLIPKRSS--FRVICVPIKRSLKLLNKKLELD--------------------------------------------------------------------------------------
Candida albicans 2 KIKLIPKRSS--FRVICVPIKRSLKLLNKKLELD--------------------------------------------------------------------------------------
Ashbya gossypii
QIRLLPKGNR--LRPIMNLRRRAMARGQSRK-----------------------------------------------------------------------------------------
Aspergillus fumigatus SLRLLPKTTG--VRPILNLRRRNLQPGWAGKAP---------------------------------------------------------------------------------------
Aspergillus clavatus SLRLLPKTTG--VRPILNLRRRMLKPGWAGKAP---------------------------------------------------------------------------------------
Neosartorya fischeri SLRLLPKTTG--VRPILNLRRRMLQPGWAGKAP---------------------------------------------------------------------------------------
Encephalitozoon cuniculi ELRCIPKMNG--ARIISNMSKAR-------------------------------------------------------------------------------------------------
Arabidopsis thaliana KFRFLPKANG--VRMVLDFSS---------------------------------------------------------------------------------------------------
Iris tectorum
RVRLIPKKHD--IRIIANARIPSKL-----------------------------------------------------------------------------------------------
Scilla peruviana
RVRFLPKKNK--MRIVANTKAPCEIKAYDQNKRS--------------------------------------------------------------------------------------
Doryanthes excelsa RVRFLPKQKC--VRILANTKVPSKIPLHRNNNRKR-------------------------------------------------------------------------------------
Oryza sativa
RVRFLPKAKD--MRPLVDLRA---------------------------------------------------------------------------------------------------
Zea mays
TVRFIPKAKD--MRPLVNLRA---------------------------------------------------------------------------------------------------
Ostreococcus tauri NMRFLPKGTG--LRPIATLNKPTTFAVKLRKKSP--------------------------------------------------------------------------------------
Tetrahymena thermophila KLRIIPKKGS--FRPIMTFLR----KDKQKN-----------------------------------------------------------------------------------------
Paramecium tetraurelia KLRIVPKPGT--FRPIVTYNR----KSRIS------------------------------------------------------------------------------------------
Paramecium caudatum KLRIVPKPGT--FRPIVTYNR----KAKTS------------------------------------------------------------------------------------------
Euplotes aediculatus KLRLIPKKTT--FRPIMTFNKKIVNSDRK-T-----------------------------------------------------------------------------------------
Euplotes crassus micronuclear KLRLIPKKTT--FRPIMTFNKKIVDPEGK-T-----------------------------------------------------------------------------------------
Euplotes crassus macronuclear KLRLIPKKTT--FRPIMTFNKKIVDPDGK-A-----------------------------------------------------------------------------------------
Oxytricha trifallax KLRLIPKGDT--FRPIMTFNRKIPNQVGKFQ-----------------------------------------------------------------------------------------
Cryptosporidium parvum KIRWVPKSKG--LRPLINLSKVGSGQILQQNLERDHTCEEKKKIGFCDCNSVWTGGDLPTSWINNNYYYNYFNSNGNNGIVGNNHNYGHINNIGGKNFTSFSSQNCQIMTPPGRLGVGLG
Cryptosporidium hominis KIRWIPKSKG--LRPLINLSKVGSGQILQQNLERDHTCEEKKKIGFCDCNSVWTGGDLPTSWINNNYYYNYYNSNGNNGTVGNNHNYGHINNIGGKNFTSFSSQNCQIMTPPGRLGVGLG
Giardia lamblia
RLSFVYKSNG-RVRPLCNFSFCS-------------------------------------------------------------------------------------------------
Giardia intestinalis RLSFVYKSNG-RVRPLCNFSFCS-------------------------------------------------------------------------------------------------
Leishmania amazonensis GVRFRPDRRK--LRPIAVVRSASLRSLKEMARGSPSPYSHASAI----------------------------------------------------------VRLLRRLGCSDADGQLPA
Leishmania infantum SVRFRPDRRK--LRPIAVVRSASLRSLKEMARGSPSPYSHASAI----------------------------------------------------------VRLLCRLGCSDTDGQLPA
Trypanosoma brucei DVRFLVDGSK--LRPIARPRFGWQRSLLKAADG--------------------------------------------------------------------------------------V
130
140
150
160
170
180
190
200
210
220
230
240
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures
Homo sapiens
--------KRAERLTSRVKALFSVLN--------------------------------YERARRPGLLGASVLGLD------DIHRAWRTFVLRVRAQD---------------------
Mesocricetus auratus --------KQAQHFTQCLKTLFSVLN--------------------------------YELTKHTNLLGASVLGLN------DIYRTWRTFVLRVRTLD---------------------
Mus musculus
--------KQAQHFTQRLKTLFSMLN--------------------------------YERTKHPHLMGSSVLGMN------DIYRTWRAFVLRVRALD---------------------
Rattus norvegicus --------KQTQCFTQSLKTLFSVLN--------------------------------YERTKHPNLMGASVLGTS------DSYRIWRTFVLRVRALD---------------------
Canis familiaris
--------KKVQHLTSQLKTLFSVLN--------------------------------YERARRPSLLGASMLGMD------DIHRAWRTFVLRIRAQN---------------------
Bos taurus
--------KKVQHLSSRVKTLFAVLN--------------------------------YERARRPGLLGASVLGMD------DIHRAWRAFVLPLRARG---------------------
Coturnix japonica --------KKIQRYNTQLKNLFSVLN--------------------------------YERTVNTSIIGSSVFGRD------DIYRKWKEFVTKVFESGG--------------------
Gallus gallus
--------KKIQRYNTQLKNLFSVLN--------------------------------YERTVNTSIIGSSVFGRD------DIYRKWKEFVTKVFESGG--------------------
Xenopus laevis
--------KKIHHFSSQIRNLFSVLN--------------------------------YEWNRNCSLIGSSVFGMD------DIYKKWKKFVLDFEKPQV--------------------
Oryzias latipes
--------SNTRLHHKRIRDLMSMLQ--------------------------------ARVRSAPALLGSTVWGMT------DIHKVLRSLAPAQKDKP---------------------
Oryzias melastigma --------LHTRLHHWCIRDLMDLLQ--------------------------------ARVRSMPSLLGSTVWGLT------DIHKVLSSLAPAQKAKP---------------------
Epinephelus coioides --------AKTRVYRGRVRDLLDMLR--------------------------------ACVRSTPSLLGSTVWGMT------DIHRVLRSQAPAQKDKP---------------------
Takifugu rubripes --------AKTRLYQSHVRDLLDMLR--------------------------------ACVCSTPSLLGSTVWGMT------DIHKVLSSIAPAQKEKP---------------------
Danio rerio
--------DTLQYFQSCVRVLQNVLS--------------------------------VCVREAPGPMGSTVWGWQ------DIHRRLQDFSPQQKSSP---------------------
Ciona intestinalis --------ADKMPDMVPFEVIASVLK--------------------------------LVCSKVPQATGFATQHHA------HIYNGWKLFVLSLAGIP---------------------
Ciona savignyi
--------PKEPSSKMSFNSISSVLK--------------------------------LALQRFPDSLGFAIKDRS------DIYCKWRQFLLKLKEIN---------------------
Apis mellifera
----------KFRDTDYLFIIFKFLK-------------------------------------QLYVTNYEVINFP---------KKWKSIVQKLNSKT---------------------
Bombyx mori
-------LNKRQKYR--IKEKLQLLKL-------------------------------LTGNQQHKIETAYPK-------------LHSKWLELN-------------------------
Bombyx mandarina
-------LNKRQKYR--IKEKLQLLKL-------------------------------LTGNQHHKIETAYPK-------------LHSKWLELN-------------------------
Tribolium castaneum --------------DSARKPFFKLLT-----------------------------------SKIYKVLEEKYKTSG------SLYTCWSEFTQKTQGQ----------------------
Caenorhabditis elegans ------KAIDKKTETMQWKRLNSMLS-------------------------WCLERSGVYR-----------HTIR------DSCKKVSDFLKKNSQN----------------------
Caenorhabditis remanei ------NPIDKVKDKMHWKKVNSMLT-------------------------WCLEKGGETR-----------QSIN------SSCKILLKFLRRNDTF----------------------
Schizosaccharomyces pombe -------KKMLVSTNQTLRPVASILK-------------------------------------HLINEESSGIPFN-----LEVYMKLLTFKKDLLKHRMFG------------------
Saccharomyces cerevisiae -ADEEEFTIYKENHKNAIQPTQKILEY---------------------------------LRNKRPTSFTKIYSPT------QIADRIKEFKQRLLKKFNN-------------------
Saccharomyces kudriavzevii -ADEEEFMVYKENHKRVIAPTQKILEY---------------------------------LRNKRPTDFVKIYSPT------QIADRIKEFKQGLLKKFNN-------------------
Saccharomyces bayanus -ADEEEFAVYKENHKKAVTPTQKILEY---------------------------------LRKKRPTSFTKIYSPT------QISDHIEKFKQILLKKFDN-------------------
Saccharomyces paradoxus -ADEEEFMIYKENHKNAVAPTQKVLEY---------------------------------LRNKRQTSFTKMYSPM------QIADRIKEFKQSLLKKFNN-------------------
Saccharomyces mikatae -ADDEEYMIYKENHKNAVAPTQKILEY---------------------------------LRNKRLTSFTKIYSPT------QIADRIKEFKLSLLKKFNN-------------------
Kluyveromyces lactis -VNIQEFNEFNDYVTNALKPTKIILER---------------------------------LRMRRNTKFTKAFSPL------EIPKIVLSYKQRLLLKHG--------------------
Candida albicans 1 -TLEKEKREFERYRKEVLSPVGQILRLK-----------------------------LSKLRDTYESYRASVHSSS------DVAEKISDYRDSLLTRFG--------------------
Candida albicans 2 -TLEKEKREFERYRKEVLSPVGQILRLK-----------------------------LSKLRDTYESYRASVHSSS------DVAEKISDYRDSLLTRFG--------------------
Ashbya gossypii
---------LGLSINTVLGPIHSLLK--------------------------------LER----------------------------AFKGTLGPDPG--------------------
Aspergillus fumigatus --------FLGPSINSTMTPIFNVLK--------------------------------YETARNPASLGSTLSFVG------EIHTRLKSFKERLSQSHSS-------------------
Aspergillus clavatus --------FLGPSINSTIAPVFNVLN--------------------------------Y