10 20
30 40
50 60 70 80 90 100 110 120
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures
Schizosaccharomyces pombe ---------------------------------------MTEHHTPKSRILRFLENQYVYLCTLNDYVQLVLRGSPASSYSNICER-------------LRSDVQTSFSIFLHSTVVGFD
Saccharomyces cerevisiae
------------------------------------------------------------MKILFEFIQDKLDIDLQTNSTYKE--------------NLKCGHFNGLDEILTTCFALPN
Saccharomyces paradoxus ------------------------------------------------------------MRSLYEFTQDKLNIDLETCIIYQE--------------NFKCGQFNGLDEILTTCFILQN
Saccharomyces mikatae ------------------------------------------------------------MKSLYDFIQDKLEIELETNITYEE--------------NIESGQFNGLDEILTTCFILQN
Saccharomyces kudriavzevii ------------------------------------------------------------MKSLYEFIQDKLGTDFESNALNQD--------------NFECGQFNGLDELLTTCFILPN
Saccharomyces bayanus ------------------------------------------------------------MISLSEFIHDKLNTDLETNALHHD--------------VLKYGQFNGLNELLTTCFILPN
Kluyveromyces lactis ------------------------------------------------------------MKILVEYLES---LECYETLRKSD--------------ILINADSNGVSNLLLSCFAQVN
Candida albicans 1 ------------------------------------------------------------MTVKVNEKKTLLQYVLDNTSNDVP--------------LLPS-----LKEYMETVLVYKS
Candida albicans 2 ------------------------------------------------------------MTVKVNEKKTLLQYVLDNTSNEVP--------------LLPS-----LKEYMETVLVYQS
Ashbya gossypii MSFKEKRK--------------------LEATDASSDRKRVRTSRDTLVKRDLLDRCYDKVTTLREYILLKLPPRSRLRRKKVASVGE---------GDDVGELESNLSRLLDTSLVCFD
Aspergillus fumigatus MGQKRKRPVKDGCAAD-----NSALRRIISASSGSRNHGASARNEKDGHSHPVISLYYRQVVTLRQYLLQQIPVTSKSRRRRIASIRSDPLTQREGDDSPGDRQVQDLASVLDTTLVGVL
Aspergillus clavatus MGKKRKRPSKDSGAGE-----DLAQKRLAGGPNGVRSHHATDAYEGSGHSHPVISLYYHRVVTLRQYLLQQIPVSSKSRRRRITSVQGATSTEKQKNRGVRGYHAQGLADILDTTLVGVL
Aspergillus nidulans MGKKRKRPVKEPVKDDPICRAKSSPQQPAGNTARSLSTNRNQAADAGKICHPVISLYYRHVVTLRQYILQRIPRSSRARRRRIAAVGG--HSAARDGLAAVPKNEKDLADLLDTTLVGIL
Neosartorya fischeri MGKKRKRPIKDGCTAD-----NSAPRRIISTSGGSRNHGASARKEKDGHSHPVISLYYRQVVTLRQYLLQQIPVTSKSRRRRIASIRSDPLTQSQGDDSSGERQVQDLASVLDTTLVGVL
Encephalitozoon cuniculi
----------------------------------------------------------MKIYKSRQMLELLKSFGFLSLRDFLAAYG-----------------VADLPDIVDRVYVRAS
130
140
150
160
170
180
190
200
210
220
230
240
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures
Schizosaccharomyces pombe SKP-------------------------DEGVQFSSPKCSQSELIANVVKQMFDESFE---RRRNLLMKGFSMNHEDFR----AMHVNGVQNDLVSTFPNYLISILESKNWQLLLEIIG-
Saccharomyces cerevisiae
SR--------------------------KIALPCLPGDLSHKAVIDHCIIYLLTGEL-----YNNVLTFGYKIARNED-----------VNNSLFCHSANVNVTLLKGAAWKMFHSLVG-
Saccharomyces paradoxus SR--------------------------KVALPYLPGDLSHKAVIDHCIIYLLTGEF-----YNNVLTFGYKIARNED-----------VDNSLFCHSANVNVTLLKGVPWEMFHSLIG-
Saccharomyces mikatae SR--------------------------KIALPSVSGDLNHKAIIDHCIVYLLTGEF-----FNNVLTFGYKIAKNED-----------VDNSLFCHSTNVSVTLLKGTAWKMLHNLIG-
Saccharomyces kudriavzevii SR--------------------------KIALPSISGDLNHKSVVDQCITYLLSGDF-----FNNVLTFGYRIARNEN-----------VNNSLFCHSTNVSVTLLKSTTWRMFHDLIG-
Saccharomyces bayanus SR--------------------------KIALPSIAGDLNHKSVIDQCIIHLLTGDF-----FNNVLTFGYRIARNEN-----------VDNSLFCHSTNVSATLLKSSTWELLHGLIG-
Kluyveromyces lactis SKH---------------------CVPPEIEISSTFSSSYHCETIETCILYLLHKNF-----TNNILTYGYQLGKNSD-----------VMTKLFCRSSNISVSVLKCNSWRLFHQLVG-
Candida albicans 1 IKR---------------------------PLPAIRPQESFDEFMKELVTRLVMEK------SNNVIAYGYKTSAMESR----------SIFTTFHSSGNFILTHITSHNWSTIFSLLG-
Candida albicans 2 IKR---------------------------PLPAIRPQESFDEFMKELVTRLVMEK------SNNVIAYGYKTSAMESR----------SIFTTFHSSGNFILTHITSHNWSTIFSLLG-
Ashbya gossypii NDQQNVKDVDMRKKQLIEFTQKGDESYVSLSDGISGSVFSQDEIMDFVVWLLFQRE--PHARPKHILCDGFQKLAGQN------GQGTTNIPDLSIRHHNSHVKALRESPWPQLLALLG-
Aspergillus fumigatus NET-SPTVTQERRRDFAAYSQTQSQCRSELTSTDTGPPCSQSEIVDFVITSLFNRNGFSYHRPQHLLAHGYQRAGASERMTDNLAAPTSSIPGLVVRFPNRNVETLKHAPWTNVLALLG-
Aspergillus clavatus KES-SPTVTQERLRDFASYSQSQSQGRSEVPSTDVGPPCAQSEIVDFVISALFNRHAFSYQKPQHLLTHGFQRAGGPD------VKLASSIPGLARRYPNKNVQCLKQAPWTDVLGLLG-
Aspergillus nidulans KEL-PPTRSEERRRDFIAFTQAQQTTQT---GTDSGP------IVDFAISSIFNRP--SHGKLENVLSHGYRQG---------GGRLPCSIPNVAAQFPNKNVQMLKQSPWTEVLALLG-
Neosartorya fischeri NET-SPAVTQERRREFAAYSQTQSQCRSELTSTDTGPPCPQSEIVDFVITSLFNRNGFSYHRPQHLLAHGYQRVGAPERMTDNHAAPTSSIPGLVVRFPNRNVETLKHEPWTNVLALLG-
Encephalitozoon cuniculi
RTP---------------------------VVSSFKSTQKDVELISKAVRTLLIKNR------DNHLCAGYKWWSPGLPG---------ASTKIICYFPNSSSRILRSHEWSWLMRSIGD
250
260
270
280
290
300
310
320
330
340
350
360
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures
Schizosaccharomyces pombe SDA---MHYLLSKGS--IFEALPNDNYLQISGIPLFKNNVFEET--------------------------------------------------------VSKKRKRTIETSITQNKSAR
Saccharomyces cerevisiae
TYA---FVDLLINY---TVIQFNGQFFTQIVGNRCNEPHLPPK-----------------------------------------------------------------------------
Saccharomyces paradoxus TNS---FVDLLINY---TVVQFNGQFFAQIVGNRCNEPHLPPK-----------------------------------------------------------------------------
Saccharomyces mikatae TNA---FVDMLINH---TVIQFNGHFFTQIIGNRCNEPHLPPK-----------------------------------------------------------------------------
Saccharomyces kudriavzevii TYA---FVDILVNY---TVIQFNGQFFSQIVGNKCNEPHLPPK-----------------------------------------------------------------------------
Saccharomyces bayanus THA---FVDLLINY---TVVQFNGKFFTQIVGNRCNEPHLPPK-----------------------------------------------------------------------------
Kluyveromyces lactis TDN---FVNLLINY---SVYFNTGHYFRQIIGTPANAPQVPPA-----------------------------------------------------------------------------
Candida albicans 1 PKK---FLELLVN---------NKGFVSKVNGE--SVQIFGDV-----------------------------------------------------------------------------
Candida albicans 2 PKK---FLELLVN---------NKGFVSKVNGE--SVQIFGDV-----------------------------------------------------------------------------
Ashbya gossypii KAGEEIMIKLLVDASIYVAVEAGLNNYHQLSGVPLAELD---------------------------------------------LPGGNVSLNKGSAPSDSSNLDAGS------------
Aspergillus fumigatus GNGEEIMLRLLLDCGIFTAIDHRKGIYYQLSGLPLSSLEPVKR---QLPQEVSDLSGASIKTANNTGGFCSGPQHRKSVRQEVVHKPNSIVFFRRRMLYAKPVLNSKGDVHFGLTRLHVL
Aspergillus clavatus GNGEEIMLRLLFDCGIFMAIDHRKGIYYQISGLPLSSLEPIQN---QSPLEVPNANSKPSLAAGSN-----VARKNRSSDQGIAHKPNSVVFFRRRMLYAKPILNSRGEVHFGLSALHVL
Aspergillus nidulans SNGDEIMLKLLLDCGLFMAVDARKGVYCQISGQAISSLKPIDTSPEDCPAAFNGSSSPVKRHAVPWQGAAPRAHTKGPKENQQQLSPNAIIFCRQRMLYARPHLNANGGITFGLPN-HVL
Neosartorya fischeri GNGEEIMLRLLLDCGIFTAIDHRKGIYYQISGLPLSSLEPVKR---ELPQEVSDLSGASIHTANSTGGFCSGLKKRKSVRQEVVHKPNSIVFFRRRMLYAKPVLNSKGDVHFGLTRLHVL
Encephalitozoon cuniculi
ELAFFILTECLVIQMLNSGYVFLAGDFKSLSGMATER-----------------------------------------------------------------------------------
370
380
390
400
410
420
430
440
450
460
470
480
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures
Schizosaccharomyces pombe KEVSWNSISISRFSIFYRSSYKKFKQDLYFNLHSICDRNTVHMWLQWIFPRQFGLINAFQVKQLHKVIP--------LVSQSTVVPKRLLKVYPLIEQTAKRLHRISLSKVYNHYCPYID
Saccharomyces cerevisiae
--WAQRSSSSSATAAQIKQLTEPVTNKQFLHKLNINSSSFFPYSKILPSSSSIKKLTDLREAIFP-------------TNLVKIPQRLKIRMNLTLQKLLKRHKRLNYVSILNSICPPLE
Saccharomyces paradoxus --WAQRTS--SGNTAQIKQLMGPVTNKPFLHRLKINSPSFFPYGKILPLSSSFKKLTDVRETIFP-------------INLVKIPQRLKVRINLTLQKLLKRHKRLNYVSVLNSICSPSE
Saccharomyces mikatae --WAQRSSPSSGSIAQIEPVMEPVTNKPFLHKLKLNCPFIFPYKTILSLSSSIEKLIELRENIFP-------------SYLVKIPQKLEVQINLTLQKLLIRHKRLSYVSILNGICPRLK
Saccharomyces kudriavzevii --WAQRASSSSERTVQMKQLTRPVTNKSFLHKLKTNSSTFFPYGRILSSSSSINRLSELREAIFP-------------SNLIKVPQRLKIGIDLTLRKMLTRHKGLNYVSILNNICPPLI
Saccharomyces bayanus --WVKKSSSPSDTTLLMKQLMEPITNKPFLHRLKINSPNFFPYGRILPSSSTLNKLTELRDAVFP-------------PNLVKIPQSLRIRVNITLQKLLTRHKRLNYVSILNNICPQLK
Kluyveromyces lactis --WLDRSYRRERNTKLTIDWNSALYHKIRPQDYKN----IIETDQGLLIAEIFPKISESSKTPRS-------------LNFALN------NLKPILYELIRAHERFSYRHIINNICPKSD
Candida albicans 1 --NSHRKAVVVSKYITKFNVLYNSYSRDFSRFEMIRPSIQTILQDILSFSGLNPGRSSKRYRGFK-------------SLLSRIIANDKKCRYDILYAKFIGTSKCNFANVVS-------
Candida albicans 2 --NSHRKAVVVSKYITKFNVLYNSYSRDFSRFEMIRPSIQTILQDILSFSGLNPGRSSKRYRGFK-------------SLLSRIIANDKKCRYDILYAKFIGTSKCNFANVVS-------
Ashbya gossypii ---------HGVIKIMMYMFPRQFGLHNVFTFQVDHTKTSQKFQDYTSREEEIAPIFQAKPGDAASRKP-------------KIPKRLRGDVEQLVKRLQILHSRCSYTELLSYYCSCVF
Aspergillus fumigatus NRYPRSDSLSETVHILKYIFPRQYGLHNVFTSVTDSRETVMPFKDYFSRETEIAQMDEQKRKRRQRIGPGFMNHFEKHKDLVEIPKRLRGKAVELVQQLQNRNRRCPYVKLLDYYCPADD
Aspergillus clavatus NRYPRSDSLSQTVHILKYIFPRQFGLHNVFTSVTDSRETVLPFKDYFSRETEIEEIEEKRRKQRRRIGPEFTNHYQDQKEFIDIPKRLRGKACELVQQLQNRNRRCPYTELLNYYCPPVD
Aspergillus nidulans SRFHSAKSLQQTVHVMKYVFPRQFGLHNVFTSHSSYYENPLS-KNYSSREEEIARKEGLEAARNQLRKSGFHAAIGERQESIKIPKRLRGKPLELIRQLQNRSRRCCYKKLLQYYCSEEL
Neosartorya fischeri NCYPRSDSLSETVHILKYIFPRQYGLHNVFTSVTDSRETVLPFKDYFSRETEIAQIDEQKRKRRQRIGPGFTNHFEKHNDLIEIPKRLRGKAVELVQQLQNRNRRCPYVKLLDYYCPIED
Encephalitozoon cuniculi
-------------------VSNAIGRNVLFYKETRRISFCSLSAFEYVFEAHNSEKYKVIQKDAR----------------------------DVLESIERRWKKISTHAIFKSFFKDEL
490
500
510
520
530
540
550
560
570
580
590
600
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures
Schizosaccharomyces pombe T------------------------------------------------------------------HDDEKILSYSLKPNQVFAFLRSILVRVFPKLIWG----NQRIFEIILKDLETF
Saccharomyces cerevisiae
G-----------------------------------------------------------------TVLDLSHLSRQSPKERVLKFIIVILQKLLPQEMFG----SKKNKGKIIKNLNLL
Saccharomyces paradoxus E-----------------------------------------------------------------TVSNLSHLSRQSPKEQVLRFIIVILQKLLPQEMFG----SKKNKCKIIRNLNLL
Saccharomyces mikatae E-----------------------------------------------------------------TTSELPHLSRQSPKEEVLKFVIVILQKLLPQEMFG----SKKNKCKIIKNLNSL
Saccharomyces kudriavzevii E-----------------------------------------------------------------NGSELSHLGWQLPKEQVLRFLIVILEKLLPKEMFG----SKKNKCKIIRNLNSL
Saccharomyces bayanus E-----------------------------------------------------------------NASELPHLKSQLPQSQVLKFLIVILQKLLPQEMFG----SKRNKCKIIQNLNSL
Kluyveromyces lactis --------------------------------------------------------------------------TFYSSPKSVIKLLIVCVRKTFPLDLLG----SNSNYSVLSKAIAIL
Candida albicans 1 ---------------------------------------------------------------------------NKTEISQVIQFVLLVLGKLLPLDAWG----GVSNKKIIKDRVVDF
Candida albicans 2 ---------------------------------------------------------------------------NKTEISQVIQFVLLVLGKLLPLDAWG----GVSNKKIIKDRVVDF
Ashbya gossypii DRPSQIRKPKAKKIPMSTRKPKPSQHPFS--RSNQKCVSSQMHPEAGTSG-----------TQVQSLPEHDSLVELATPSFQVSSFCRAVLSKIIPDSFWGDKDAGKHNKSIAMRNVDHF
Aspergillus fumigatus VWPWKLSHTNSQEGSTGEEPRTPSDRLVTQPRGAEQHAARDVGPKESPKIRYSTHDTEDGTTKCLVPEPKQNLMDYATPSSSVSAFCRAVLRKLIPPQFYGIGQYQKSNQEIIFSHVDRF
Aspergillus clavatus TGPWKLGPTDSQTSHPSG--TAISESLVTQRRGPQGSF