10 20
30 40
50 60 70
80 90 100 110 120
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
|------------------------------------------
Homo sapiens -----------------MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWR---LVQRGDPAAFRALVAQCLVCVPWDARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFG
Mesocricetus auratus
-----------------MPRAPRCRAVRALLRSQYRQVWPLATFVRRLGPEGRQ---LVQPGDPKVFRTLVARCLVCVPWDSQPPPADLSFHQVSSLKELVARVVQRLCERGERNVLTFG
Mus musculus -----------------MTRAPRCPAVRSLLRSRYREVWPLATFVRRLGPEGRR---LVQPGDPKIYRTLVAQCLVCMHWGSQPPPADLSFHQVSSLKELVARVVQRLCERNERNVLAFG
Rattus norvegicus
-----------------MPRAPRCPAVRSLLRSRYREVWPLATFVRRLGLEGSR---LVQPGDPKVFRTLVAQCLVCVPWGSQPPPADLSFHQVSSLKELVSRVVQKLCERGERNVLAFG
Canis familiaris -----------------MPRAPRCRAVRALLRGRYREVLPLATFLRRLGPPGRL---LVRRGDPAAFRALVAQCLVCVPWGARPPPAAPCFRQVSCLKELVARVVQRLCERGARNVLAFG
Bos taurus -----------------MPRAPRCRAVRALLRASYRQVLPLAAFVRRLRPQGHR---LVRRGDPAAFRALVAQCLVCVPWDAQPPPAAPSFRQVSCLKELVARVVQRLCERGARNVLAFG
Coturnix japonica
MERGADPGVGVRRRLHNMARAEPFAAVLGALRGCYAEATPLEAFVRRLQDGGTGEVEVLRGDDAQCYRTFVSQCVVCVPRGARPIPRPICFQQLSSQNEVITRIIQRLCEKKKKNILAYG
Gallus gallus MERGAQPGVGVRR-LRNVAREEPFAAVLGALRGCYAEXTPLEAFVRRLQEGGTGEVEVLRGDDAQCYRTFVSQCVVCVPRGARAIPRPICFQQLSSQSEVITRIVQRLCEKKKKNILAYG
Xenopus laevis -----------------MPLRTGGATLLSILQRLYGQVLGIVEYTDTLQVPGGIKVPVLLEGDSEKFRSFVAELVVCIPRGTKPLPSPVSFLQLSTQREVVARVIQRICEKKRKNVLAFG
Oryzias latipes ------------------MTSGDLSSVLNILRSLYKRTRTLEEFADGVVFREGRRAALLQPSDTHSFKSFVRGVFVCSDEELQDVPSC---NQTCTFPELLAFILNSLKRKRRRNVLAHG
Oryzias melastigma
------------------MTSEDVSRVLELLRSLYKRTQTLQEFADGVVFRDGRRATLLQPSDSIVFQTFVRAVFVCSDEELREVRSS---KQICTFSEILAFVLNNLKRSKSNNVLAQG
Epinephelus coioides
------------------MSTADLSPTLDILRSVYQHVQTLEQFTDSIVFREGHRAQLTEHTDTNRFKSFVRGVFVCFDRELQQVPSC---NRICTLPELLAFVLNSLKRKRKRNILAHG
Takifugu rubripes
------------------MSITDLSPTLGILRSLYPHVQVLVDFADDIVFREGHKATLIEESDTSHFKSFVRGIFVCFHKELQQVPSC---NQICTLPELLAFVLNSVKRKRKRNVLAHG
Danio rerio -------------MSGQYSTDGGFRPVLEILRSLYPVVQTLEEFTDGLQFPDGRKPVLLEETDGARFKKLLSGLIVCAYT-PPQLRVP---AQLSTLPEVLAFTLNHIKRKKLRNVLGFG
region
|-----------------------------------------region
v-Ia----------------------------------|
|-----------------------------------------------------------------------RI
|-------------------------DAT
d
130
140
150
160
170
180
190
200
210
220
230
240
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
-motif
GQ------------------------------------------------------------------------------------|
Homo sapiens FALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPR--------------RRLGCERAWNHS
Mesocricetus auratus
FALLNGAQGGPPMTFTTSVRSYLPNSVTESLRVSGAWMLLLNRVGDDLLVYLLARCALYLLVPPSCAYQVCGSPLYQICATAETWPSVSRIYRPTRPVG-----RNFTHLGSTHRVRNSS
Mus musculus FELLNEARGGPPMAFTSSVRSYLPNTVIETLRVSGAWMLLLSRVGDDLLVYLLAHCALYLLVPPSCAYQVCGSPLYQICATTDIWPSVSASYRPTRPVG-----RNFTNLRFLQQIKSSS
Rattus norvegicus
FALLNGARGGPPMAFTTSVHSYLPNSVTESLCVSGAWMLLLSRVGDDLLVYLLSHCALYLLVPPSCAYQVCGSPLYQICATTDTWSSVPAGYRPTRPVG-----GNFTNLGSAHQIKNSG
Canis familiaris FALLDGARGGPPVAFTTSVRSYLPNTVTETLRGSGAWGLLLRRVGDDVLTHLLARCALYLLVAPSCAYQVCGPPLYDLCAPASLPLPAPGLPGLPGLPG--------------LGAGAGA
Bos taurus FTLLAGARGGPPVAFTTSVRSYLPNTVTDTLRGSGAWGLLLHRVGDDVLTHLLSRCALYLLVPPTCAYQVCGPPLYDLRAAAAAARRPTRQVGGTRAGF----------GLPRPASSNGG
Coturnix japonica
YSLLDENSCHFRVLPSSCIYSYLSNTVTETIRISGLWEILLSRIGDDVMMYLLEHCALFMLVPPSNCYQVCGQPVYELISRNIGPSPGFVRRRYSRFKHNSLLDYVRKRLVFHRHYLSKS
Gallus gallus YSLLDENSCHFRVLPSSCIYSYLSNTVTETIRISGLWEILLSRIGDDVMMYLLEHCALFMLVPPSNCYQVCGQPIYELISRNVGPSPGFVRRRYSRFKHNSLLDYVRKRLVFHRHYLSKS
Xenopus laevis YGLVDE-KNSLNIRLTPNICNYFPNPTTTTISTSILWETLLTRVGDDVMMYWLEQCSIFVFVPPRCCYQITGQPIYTLPSDDVFLFQSQSFTQSNVLLRYIKRNVFHLRKKYLKPKHSMT
Oryzias latipes YNFLGVAQEDRDADHFRFQGD-LSQSAAY-IHSSDLWKKVTARLGTDVTRYLLGSCSVFVLAPPSCIFQICGVPAYDRVSMTTASSGFLLRPPSRKHKSFQVGKKRRSANLTKRGSVGDV
Oryzias melastigma
YNWKT-AQENKDVNLFRFQGD-LSQSANY-IHSSEQWKKVMAHLGPDFLLHLLGSFSVFVVAPPSCVFQICGAPAYDRVSVTTASSRFLLKHPSRRHTSSRLGKNRCSVKFKMRDSAEDE
Epinephelus coioides
YSFLSLAQEERDADHFKSQGD-ITQSAAY-IHGSDLWKKVTIRLGTDITRYLLESCSVFVAVPPSCVFQVCGAPVYDRVSMTTAPAGFCLQSRARTLNGGQAGRNRGAVTVRRKHKVEND
Takifugu rubripes
YNFQSLAQEERDADQFKLQGD-VTQSAAY-VHGSDLWRKVSMRLGTDITRYLFESCSVFVAVPPSCLFQVCGIPIYDCFSLATASLGFSLQSRG--CRERCLGVNSMKRRAFNVKRYLRK
Danio rerio YQCSDVTTS---SDPFRFHGD-VSQTAAS-ISTSEVWKRINQRLGTEVTRYLLQDCAVFTTVPPSCVLQVCGEPVYDLLMPRSWSGFFLSNSDNERISGAMRKFPAVQKTVAISKKRTRD
region
|-------------region
v-Ib----------------|
D1--------------------------------------------------------|
omain-------------------|
|--------------motif T2------------------|
250
260
270
280
290
300
310
320
330
340
350
360
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
Homo sapiens VREAGVPLGLPAPGARRRGGSASRSLPLPKRPR---------------------------------------------------------------------------------------
Mesocricetus auratus
HQEAWKPPPLPSREAKRSLSITNRSVPPSKKAR---------------------------------------------------------------------------------------
Mus musculus RQEAPKPLALPSRGTKRHLSLTSTSVPSAKKAR---------------------------------------------------------------------------------------
Rattus norvegicus
HQEAPKPQALPSRGTKRLLSLTSTNVPSAKKAR---------------------------------------------------------------------------------------
Canis familiaris SADLRPTRQAQNSGARRRRGSPGSGVPLAKRPR---------------------------------------------------------------------------------------
Bos taurus HGEAEGLLEARAQGARRRRSSARGRLPPAKRPR---------------------------------------------------------------------------------------
Coturnix japonica
QWWKCKPRHQGHVSSRRKRSQ-RIQSLRPGYQSSEKVDFQAGRHISIVNAHMEKQSCSSLCLPNRAPSLKRKRDGEQVEIAAKRVKVMEKEIEKQACSIIPDVNQSSSQRH-RTWHVAPR
Gallus gallus QWWKCRPRRRGRVSSRRKRRSHRIQSLRSGYQPSAKVNFQAGRQISTVTARLEKQSCSSLCLPARAPSLKRKRDGEQVEITAKRVKIMEKEIEEQACSIVPDVNQSSSQRHGTSWHVAPR
Xenopus laevis SRMLTWRRNKSPSGLLIRSKTSMAVTTEIHSKRKLCSKDICVIPDKKRRDNLDKDDTVDHFDLPMCRSVSYL------------------------------------------------
Oryzias latipes EESRKRRRVESGVSARKRKREPEEEESRERRRG---------------------------------------------------------------------------------------
Oryzias melastigma
EKRRKKRRVESTNSSRKRKREPEEEESSKRRCD---------------------------------------------------------------------------------------
Epinephelus coioides
KRNRRVKKRQRQ--ADEKDEEEVMTCPGKRRRVG--------------------------------------------------------------------------------------
Takifugu rubripes
RKTETDQKDE------------ARVCSGKRRRV---------------------------------------------------------------------------------------
Danio rerio NEKYISVKRRRVKETVNNNNGNYRSLCFAISKKRAIDNEENISLKRRR------------------------------------------------------------------------
region
370 380 390 400 410 420 430 440 450 460 470 480
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
Homo sapiens ----------------------------RGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHF
Mesocricetus auratus
------------------------------CDLAPRLEKGPYRQAVPTPSDKTWVPNPAKSHAVPISRTTKEDLSSGVKAPGLSRSGSVCYKHKPSSTSLQSPLCQNAFQLRPYTETKRF
Mus musculus ---------------------------------CYPVPRVEEGPHRQVLPTPSGKSWVPSPARS