10 20
30 40
50 60 70
80 90 100 110 120
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
|------------------------------------------
Homo sapiens -----------------MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWR---LVQRGDPAAFRALVAQCLVCVPWDARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFG
Mesocricetus auratus
-----------------MPRAPRCRAVRALLRSQYRQVWPLATFVRRLGPEGRQ---LVQPGDPKVFRTLVARCLVCVPWDSQPPPADLSFHQVSSLKELVARVVQRLCERGERNVLTFG
Mus musculus -----------------MTRAPRCPAVRSLLRSRYREVWPLATFVRRLGPEGRR---LVQPGDPKIYRTLVAQCLVCMHWGSQPPPADLSFHQVSSLKELVARVVQRLCERNERNVLAFG
Rattus norvegicus
-----------------MPRAPRCPAVRSLLRSRYREVWPLATFVRRLGLEGSR---LVQPGDPKVFRTLVAQCLVCVPWGSQPPPADLSFHQVSSLKELVSRVVQKLCERGERNVLAFG
Canis familiaris -----------------MPRAPRCRAVRALLRGRYREVLPLATFLRRLGPPGRL---LVRRGDPAAFRALVAQCLVCVPWGARPPPAAPCFRQVSCLKELVARVVQRLCERGARNVLAFG
Bos taurus -----------------MPRAPRCRAVRALLRASYRQVLPLAAFVRRLRPQGHR---LVRRGDPAAFRALVAQCLVCVPWDAQPPPAAPSFRQVSCLKELVARVVQRLCERGARNVLAFG
Coturnix japonica
MERGADPGVGVRRRLHNMARAEPFAAVLGALRGCYAEATPLEAFVRRLQDGGTGEVEVLRGDDAQCYRTFVSQCVVCVPRGARPIPRPICFQQLSSQNEVITRIIQRLCEKKKKNILAYG
Gallus gallus MERGAQPGVGVRR-LRNVAREEPFAAVLGALRGCYAEXTPLEAFVRRLQEGGTGEVEVLRGDDAQCYRTFVSQCVVCVPRGARAIPRPICFQQLSSQSEVITRIVQRLCEKKKKNILAYG
Xenopus laevis -----------------MPLRTGGATLLSILQRLYGQVLGIVEYTDTLQVPGGIKVPVLLEGDSEKFRSFVAELVVCIPRGTKPLPSPVSFLQLSTQREVVARVIQRICEKKRKNVLAFG
Oryzias latipes ------------------MTSGDLSSVLNILRSLYKRTRTLEEFADGVVFREGRRAALLQPSDTHSFKSFVRGVFVCSDEELQDVPSC---NQTCTFPELLAFILNSLKRKRRRNVLAHG
Oryzias melastigma
------------------MTSEDVSRVLELLRSLYKRTQTLQEFADGVVFRDGRRATLLQPSDSIVFQTFVRAVFVCSDEELREVRSS---KQICTFSEILAFVLNNLKRSKSNNVLAQG
Epinephelus coioides
------------------MSTADLSPTLDILRSVYQHVQTLEQFTDSIVFREGHRAQLTEHTDTNRFKSFVRGVFVCFDRELQQVPSC---NRICTLPELLAFVLNSLKRKRKRNILAHG
Takifugu rubripes
------------------MSITDLSPTLGILRSLYPHVQVLVDFADDIVFREGHKATLIEESDTSHFKSFVRGIFVCFHKELQQVPSC---NQICTLPELLAFVLNSVKRKRKRNVLAHG
Danio rerio -------------MSGQYSTDGGFRPVLEILRSLYPVVQTLEEFTDGLQFPDGRKPVLLEETDGARFKKLLSGLIVCAYT-PPQLRVP---AQLSTLPEVLAFTLNHIKRKKLRNVLGFG
region
|-----------------------------------------region
v-Ia----------------------------------|
|-----------------------------------------------------------------------RI
|-------------------------DAT
d
130
140
150
160
170
180
190
200
210
220
230
240
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
-motif
GQ------------------------------------------------------------------------------------|
Homo sapiens FALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPR--------------RRLGCERAWNHS
Mesocricetus auratus
FALLNGAQGGPPMTFTTSVRSYLPNSVTESLRVSGAWMLLLNRVGDDLLVYLLARCALYLLVPPSCAYQVCGSPLYQICATAETWPSVSRIYRPTRPVG-----RNFTHLGSTHRVRNSS
Mus musculus FELLNEARGGPPMAFTSSVRSYLPNTVIETLRVSGAWMLLLSRVGDDLLVYLLAHCALYLLVPPSCAYQVCGSPLYQICATTDIWPSVSASYRPTRPVG-----RNFTNLRFLQQIKSSS
Rattus norvegicus
FALLNGARGGPPMAFTTSVHSYLPNSVTESLCVSGAWMLLLSRVGDDLLVYLLSHCALYLLVPPSCAYQVCGSPLYQICATTDTWSSVPAGYRPTRPVG-----GNFTNLGSAHQIKNSG
Canis familiaris FALLDGARGGPPVAFTTSVRSYLPNTVTETLRGSGAWGLLLRRVGDDVLTHLLARCALYLLVAPSCAYQVCGPPLYDLCAPASLPLPAPGLPGLPGLPG--------------LGAGAGA
Bos taurus FTLLAGARGGPPVAFTTSVRSYLPNTVTDTLRGSGAWGLLLHRVGDDVLTHLLSRCALYLLVPPTCAYQVCGPPLYDLRAAAAAARRPTRQVGGTRAGF----------GLPRPASSNGG
Coturnix japonica
YSLLDENSCHFRVLPSSCIYSYLSNTVTETIRISGLWEILLSRIGDDVMMYLLEHCALFMLVPPSNCYQVCGQPVYELISRNIGPSPGFVRRRYSRFKHNSLLDYVRKRLVFHRHYLSKS
Gallus gallus YSLLDENSCHFRVLPSSCIYSYLSNTVTETIRISGLWEILLSRIGDDVMMYLLEHCALFMLVPPSNCYQVCGQPIYELISRNVGPSPGFVRRRYSRFKHNSLLDYVRKRLVFHRHYLSKS
Xenopus laevis YGLVDE-KNSLNIRLTPNICNYFPNPTTTTISTSILWETLLTRVGDDVMMYWLEQCSIFVFVPPRCCYQITGQPIYTLPSDDVFLFQSQSFTQSNVLLRYIKRNVFHLRKKYLKPKHSMT
Oryzias latipes YNFLGVAQEDRDADHFRFQGD-LSQSAAY-IHSSDLWKKVTARLGTDVTRYLLGSCSVFVLAPPSCIFQICGVPAYDRVSMTTASSGFLLRPPSRKHKSFQVGKKRRSANLTKRGSVGDV
Oryzias melastigma
YNWKT-AQENKDVNLFRFQGD-LSQSANY-IHSSEQWKKVMAHLGPDFLLHLLGSFSVFVVAPPSCVFQICGAPAYDRVSVTTASSRFLLKHPSRRHTSSRLGKNRCSVKFKMRDSAEDE
Epinephelus coioides
YSFLSLAQEERDADHFKSQGD-ITQSAAY-IHGSDLWKKVTIRLGTDITRYLLESCSVFVAVPPSCVFQVCGAPVYDRVSMTTAPAGFCLQSRARTLNGGQAGRNRGAVTVRRKHKVEND
Takifugu rubripes
YNFQSLAQEERDADQFKLQGD-VTQSAAY-VHGSDLWRKVSMRLGTDITRYLFESCSVFVAVPPSCLFQVCGIPIYDCFSLATASLGFSLQSRG--CRERCLGVNSMKRRAFNVKRYLRK
Danio rerio YQCSDVTTS---SDPFRFHGD-VSQTAAS-ISTSEVWKRINQRLGTEVTRYLLQDCAVFTTVPPSCVLQVCGEPVYDLLMPRSWSGFFLSNSDNERISGAMRKFPAVQKTVAISKKRTRD
region
|-------------region
v-Ib----------------|
D1--------------------------------------------------------|
omain-------------------|
|--------------motif T2------------------|
250
260
270
280
290
300
310
320
330
340
350
360
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
Homo sapiens VREAGVPLGLPAPGARRRGGSASRSLPLPKRPR---------------------------------------------------------------------------------------
Mesocricetus auratus
HQEAWKPPPLPSREAKRSLSITNRSVPPSKKAR---------------------------------------------------------------------------------------
Mus musculus RQEAPKPLALPSRGTKRHLSLTSTSVPSAKKAR---------------------------------------------------------------------------------------
Rattus norvegicus
HQEAPKPQALPSRGTKRLLSLTSTNVPSAKKAR---------------------------------------------------------------------------------------
Canis familiaris SADLRPTRQAQNSGARRRRGSPGSGVPLAKRPR---------------------------------------------------------------------------------------
Bos taurus HGEAEGLLEARAQGARRRRSSARGRLPPAKRPR---------------------------------------------------------------------------------------
Coturnix japonica
QWWKCKPRHQGHVSSRRKRSQ-RIQSLRPGYQSSEKVDFQAGRHISIVNAHMEKQSCSSLCLPNRAPSLKRKRDGEQVEIAAKRVKVMEKEIEKQACSIIPDVNQSSSQRH-RTWHVAPR
Gallus gallus QWWKCRPRRRGRVSSRRKRRSHRIQSLRSGYQPSAKVNFQAGRQISTVTARLEKQSCSSLCLPARAPSLKRKRDGEQVEITAKRVKIMEKEIEEQACSIVPDVNQSSSQRHGTSWHVAPR
Xenopus laevis SRMLTWRRNKSPSGLLIRSKTSMAVTTEIHSKRKLCSKDICVIPDKKRRDNLDKDDTVDHFDLPMCRSVSYL------------------------------------------------
Oryzias latipes EESRKRRRVESGVSARKRKREPEEEESRERRRG---------------------------------------------------------------------------------------
Oryzias melastigma
EKRRKKRRVESTNSSRKRKREPEEEESSKRRCD---------------------------------------------------------------------------------------
Epinephelus coioides
KRNRRVKKRQRQ--ADEKDEEEVMTCPGKRRRVG--------------------------------------------------------------------------------------
Takifugu rubripes
RKTETDQKDE------------ARVCSGKRRRV---------------------------------------------------------------------------------------
Danio rerio NEKYISVKRRRVKETVNNNNGNYRSLCFAISKKRAIDNEENISLKRRR------------------------------------------------------------------------
region
370 380 390 400 410 420 430 440 450 460 470 480
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
Homo sapiens ----------------------------RGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHF
Mesocricetus auratus
------------------------------CDLAPRLEKGPYRQAVPTPSDKTWVPNPAKSHAVPISRTTKEDLSSGVKAPGLSRSGSVCYKHKPSSTSLQSPLCQNAFQLRPYTETKRF
Mus musculus ---------------------------------CYPVPRVEEGPHRQVLPTPSGKSWVPSPARSPEVPTAEKDLSSKGKVSDLSLSGSVCCKHKPSSTSLLSPPRQNAFQLRPFIETRHF
Rattus norvegicus
---------------------------------FEPALRVDKGPHRQVVPTPSGKTWAPSPAASPKVPPAAKNLSLKGKASDPSLSGSVCCKHKPSSSSLLSSPPQDAEKLRPFTETRHF
Canis familiaris --------------------------------------------RSVASEPERGAHRSFPRAQQPPVSEAPAVTPAVAASPAASWEGGPPGTRPTTPAWHPYPGPQGVPHDPAHPETKRF
Bos taurus --------------------------------------------RGLEPGRDLEGQVARSPPRVVTPTRDAAEAKSRKGDVPGPCRLFPGGERGVGSASWRLSPSEGEPGAGACAETKRF
Coturnix japonica
AVGLIKERYISERSNSEMSGPSVVHRSHPGKRPVADKSSFPQGVQGNKRVKTGAEKRVESNRRGTEMCINPTHKPNRRGVERRINPSHKPGLNSVQTEPMEGASSGDRKQENPPAHLAKQ
Gallus gallus AVGLIKEHYISERSNSEMSGPSVVHRSHPGKRPVADKSSFPQGVQGNKRIKTGAEKRAESNRRGIEMYINPIHKPNRRGIERRINPTHKPELNSVQTEPMEGASSGDRKQENPPAHLAKQ
Xenopus laevis ------------------------------------SNMYPKTNVQVTGLITSGYKKTKTFQCQKPVSCEQKKTTAFYSVAGDCNLSLKDNVNKLITNASVPTAQSRLSFSNIFIDFGRT
Oryzias latipes ---------------------------------------------------VHHEERRQHEAVLDESTLSGKSGENDAAAVKPPPETSAAPPPLEGGPSWRSGAFPPLPSSQCFIRTLGF
Oryzias melastigma
----------------------------------------------------THHEESSQHACSEAVLVESTVSENDKSSLKMPPETSAASLPLEGEPSWRSGTFPPLPSSQCFIRTMGL
Epinephelus coioides
------------------------------------------QHEHTQEVQVCSESVGEGQPTSVEPSLTLKTLENGATVSKQPAETQTTTLPLEGGPSWRSGMFPPLPPSQCFIRTLGF
Takifugu rubripes
-----------------------------------------------------MEEDKVSCETMQDGESGKTTLVQKQPGSKKRSEMEATLLPLEGGPSWRSGTFPPLPPSQSFMRTLGF
Danio rerio ----------------------------------------MEETDQVAKIRNENHESQSFAISKKRARDNEENISLKRQRMEEIDQVAKIRNENHGSQSWKPADQRPPRPSQCSIRVLSM
region
490
500
510
520
530
540
550
560
570
580
590
600
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
|-motif
VSR-|
|--------motif CP-----------|
Homo sapiens LYS--SGDKEQLRPSFLLSS---------------LRPSLTGARRLVETIFLGSRPWMPGTPRRLP-------RLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVTPAAGVCA
Mesocricetus auratus
LYS-REGGRERLNPSFLLNN---------------LQPSLTGARRLVEILFLGMRPRTSGPLCGRR-------RLSKRYWQMRPLFQQLLVNHARCPYVRLLRSHCRFRTAAHQVAGA--
Mus musculus LYS-RGDGQERLNPSFLLSN---------------LQPNLTGARRLVEIIFLGSRPRTSGPLCRTH-------RLSRRYWQMRPLFQQLLVNHAECQYVRLLRSHCRFRTANQQVTDA--
Rattus norvegicus
LYS-RGGGQEELNPSFLLNS---------------LPPSLTGARRLVEIIFLGSRPRTSGPFCRTR-------RLPRRYWQMRPLFQQLLMNHAKCQYVRFLRSHCRFRTANQRVPDA--
Canis familiaris LYC--SGGRERLRPSFLLSA---------------LPPTLSGARKLVETIFLGSAPQKPGAARRMR-------RLPARYWRMRPLFQELLGNHARCPYRALLRTHCPLRAMAAKEGSGNQ
Bos taurus LYC--SGGGEQLRRSFLLCS---------------LPPSLAGARTLVETIFLDSKPGPPGAPRRPR-------RLPARYWQMRPLFRKLLGNHARSPYGALLRAHCPLPASAPRAGPDHQ
Coturnix japonica
LPNRFLRSAVYFEKKFLLYSRNYQEYFPKSFILSRLQDCQAGGRRLIETIFLSQNPVKEKQNQSLPQQKWRK-KLPKRYWQMRELFQKLVKNHKTCPYLVFLRKNCPVLLSEACLEKTEL
Gallus gallus LPNTLSRSTVYFEKKFLLYSRSYQEYFPKSFILSRLQGCQAGGRRLIETIFLSQNPLKEQQNQSLPQQKWRKKRLPKRYWQMREIFQKLVKNHEKCPYLVFLRKNCPVLLSEACLKKTEL
Xenopus laevis LYL-SISYKKGFSESFILNS---------------LDSTPSGSQKLVETIFLSNFLAEQNFDQPKRDENCRY-KLPKRYWKMKPHFQELIQNHKKFPYLVYLNKHCPVRSSMACSEKR--
Oryzias latipes LYGGRGMHGFCLNRKRRTAA---------------GPRRLQGQDLVRLVFFEGLPYLNGQERKPK--------KLPLRYFNMVPVFGRLLQRHRKCRYSSVLHRMCPVVELSRAAQG---
Oryzias melastigma
LYGGQGMQGFCLNRKKQTAA---------------GLRRLQGQDLVRLVFFQGLPYLDKQTRDPK--------KLRLRFFRMVPVFGELLQRHRKCPYTRVLQRMCPLVEESRAAPG---
Epinephelus coioides
LYGGRGMRGFLLNRKKKTPD---------------GCRRLQGTDLVRIVFFEGLAYLNGLERKPK--------KLPRRFFTMVPVFSRLLRQHRRCPYSRILQRMCPVVEDRNTQQE---
Takifugu rubripes
LYGGRGMRSFLLNRKKKTAE---------------GFRKIQGRDLIRIVFFEGVLYLNGLERKPK--------KLPRRFFNMVPLFSQLLRQHRRCPYSRLLQKTCPLVGIKDAGQA---
Danio rerio LYNGRGMKNFLLNRKLKGVG---------------GARRMQGEDLVRMIFLQ----SESNDSKPK--------KLPKRFFAMVPLFSRLLRQHRKCPYRLFLQRKC----AGNPDVK---
region
|--------------------region
v-II------------------|
|------------------------------------------------------------------------------------
610
620
630
640
650
660
670
680
690
700
710
720
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
|--------------------------------motif
QFP-----------------------
Homo sapiens REK-------------------------------------PQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRNTKKFISLG-KHAKLSLQELT
Mesocricetus auratus
-------------------------------------------------LNTTSPQRLMNLLRLHSSPWQVYGFLQACVGKLVPPGLWGSRHNQRRFFKNVKRFISLG-KYDKLSLQELT
Mus musculus --------------------------------------------------LNTSPPHLMDLLRLHSSPWQVYGFLRACLCKVVSASLWGTRHNERRFFKNLKKFISLG-KYGKLSLQELM
Rattus norvegicus
--------------------------------------------------MDTSPSHLTSLLRLHSSPWQVYGFLRACLRELVPAGLWGTRHNERRFLKNVKKFISLG-KYAKLSLQELM
Canis familiaris AHR--------------------------------GVGICPLERPVAAPQEQTDSTRLVQLLRQHSSPWQVYAFLRACLCWLVPTGLWGSRHNQRRFLRNVKKFISLG-KHAKLSLQELT
Bos taurus KCP--------------------------------GVGGCPSERPAAAPEGEANSGRLVQLLRQHSSPWQVYGLLRACLRRLVPAGLWGSRHNERRFLRNVKKLLSLG-KHGRLSQQELT
Coturnix japonica
TLQVALPGEAKVPKHTEHGKESTEGAALNSFHAPPSMPVCGQSERGEQHPAEGSDPLLGELLRQHSSHWQVYGFVRECLERVIPAELWGSSHNKCRFLKNVKAFISMG-KYDKLSLQQLM
Gallus gallus TLQAALPGEAKVHKHTEHGKESTEGTAPNSFLAPPSVLACGQPERGEQHPAEGSDPLLRELLRQHSSHWQVYGFVRECLERVIPAELWGSSHNKCRFFKNVKAFISMG-KYAKLSLQQLM
Xenopus laevis -----------------------------------SLQKNRIENDGKQLKHFTTKANLLSLLKQHSSIWQVYMFVRECLNNVVPDIMWGSSHNKCRFFRNVKSFLFFSGKFGKISLSELM
Oryzias latipes --------------------------------------------------------ELSSLIPQHCAPHRVYLFVRECLTAVVPEELWGSDHNRLQFFSRVRGFLKSG-KFERISVAELM
Oryzias melastigma
--------------------------------------------------------QPSSLIPLHCDPHRVYLFVRACLITVVPEELWGSDHNRLQFFTKVRCFLKNG-KFERVSVAELM
Epinephelus coioides
--------------------------------------------------------DLSSLLPRHCAPHRVYLFVRECLTAVIPPELWGSDHNRLHFFSRVRGFLRSG-KFERLSLAELM
Takifugu rubripes
--------------------------------------------------------ELSSFLPQHCGSHRVYLFVRECLLAVIPQELWGSEHNRLLYFARVRFFLRSG-KFERLSVAELM
Danio rerio --------------------------------------------------------DMESLLKSHSSPYRVYLFVRECLRHIIPHELWGCQENQLHFLSNVKNFLLLG-KFERLTLVQLM
region
|---------------------------------------region
---------------RID1-----------------------------------------------------------------------------------------------------
730
740
750
760
770
780
790
800
810
820
830
840
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
----------|
|--------------------motif T------------------------|
|-motif 1
Homo sapiens WKMSVRDCAWLRRSPGVGCVPAAEHRLREEILAKFLHWLMS-VYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPD
Mesocricetus auratus
WKMKVQDCRWLRSSPGNNCVPAAEHRTRERILAVFLFWLMD-AYVVELLRSFFYVTETTFQKNRLFFYRKSMWRRLQSIGVRHHLERVRLQELSQEEVRQRQEAWPAMPICRLRFIPKPS
Mus musculus WKMKVEDCHWLRSSPGKDRVPAAEHRLRERILATFLFWLMD-TYVVQLLRSFFYITESTFQKNRLFFYRKSVWSKLQSIGVRQHLERVRLRELSQEEVRHHQDTWLAMPICRLRFIPKPN
Rattus norvegicus
WRVKVEDCHWLRSSPEKDTVPAAEHRLRERILAMFLFWLMD-TYVVQLLRSFFYITETTFQKNRLFFYRKSVWSKLQSIGIRQQLERVQLRELSQEEVKHHQDTWLAMPICRLRFIPKLN
Canis familiaris WKMKVRDCTWLHGNPGACCVPAAEHRRREEILARFLVLVDGHIYVVKLLRSFFYVTETTFQKNRLFFYRKSVWSQLQSIGIRQLFNSVHLRELSEAEVRRHREARPALLTSRLRFLPKPS
Bos taurus WKMKVQDCAWLRASPGARCVPAAEHRQREAVLGRFLHWLMG-AYVVELLRSFFYVTETTFQKNRLFFFRKRIWSQLQRLGVRQHLDRVRLRELSEAEVRQHQEARPALLTSRLRFVPKPG
Coturnix japonica
WKMRVNDCVWLRLAKGNHSVPAYEHCYREEILAKFLYWLMD-SYVIELLKSFFYITETMFQKNTLFYYRKFIWGKLQNIGIRNHFAKVHLRALSSEEMDVIRQKKYFPIASRLRFIPKIN
Gallus gallus WKMRVNDCVWLRLAKGNHSVPAYEHCYREEILAKFLYWLMD-SYVIELLKSFFYITETMFQKNMLFYYRKFIWGKLQNIGIRDHFAKVHLRALSSEEMEVIRQKKYFPIASRLRFIPKMN
Xenopus laevis WSMRVEDCSWIRLQKSDHFVPASEHLLREKILAKFVFWLMD-TYVIQLLKSFFYVTETMFQKHRLLFYRKSVWKKLQNIGLRKHLEKVKLRSLSSDELENMQQWKNVPLVSRLRFIPKTN
Oryzias latipes WKIKVMDCDWLKLRRTAGRFPPSELAYRTRILSQFLTWLLD-GFVVGLVRACFYATESVGQKNAIRFYRQEVWSKLQDLAFRRHIAKGEMEELSPAQVASLP---KGTVISQLRFIPKTD
Oryzias melastigma
WKMKVMDCDWLKLRRTG-RFPPSELTYRTQILSLFLTWLLD-GFVVGLVQACFYATDSVGQKSTIRFYRPEVWNKLRDLAFRNHVAKGQMEELTPDQVASLP---KDAIISQLRFIPKAD
Epinephelus coioides
WKMKVNDCDWLKISKTG-RFPPSELSYRTQILGQFLAWLLD-GYVVSLVRACFYVTESVGQKNAVRFYRQEVWAKLQDLAFRGHLSKGQMEELTPAQVASLP---KTTVISRLRFIPKTD
Takifugu rubripes
WKIKVNNCDWLKISKTG-RVPPSELSYRTQILGQFLAWLLD-GFVVGLVRACFYATESMGQKNAIRFYRQEVWAKLQDLAFRSHISKGQMVELTPDQVAALP---KSTIISRLRFIPKTD
Danio rerio WRMKVQACHWLGPKKRQ---CASEHRYREWMLGQCMGWMLS-GFVVGLVRAQFYITESMGHKHTLRFYRGDVWSRLQDQAFRAHLCKGQWRPLSPSQALKVP---NSAVTSRIRFIPKTS
region
v-III-----------------------------------------| |---------------------region
v-IV----------------|
-------------------------------------|
850
860
870
880
890
900
910
920
930
940
950
960
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
||-2-|
|---------motif A------------|
Homo sapiens GLRPIVNMDYVV---GARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVR-AQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQ--NTYCVR
Mesocricetus auratus
GLRPIVNMSYM----GTRAFDKGKQAQHFTQCLKTLFSVLNYELTKHTNLLGASVLGLNDIYRTWRTFVLRVR-TLDPAPRMYFVKADVTGAYDAIPQDKLVEVIANMIRHPD-NSYCIH
Mus musculus GLRPIVNMSYSM---GTRALGRRKQAQHFTQRLKTLFSMLNYERTKHPHLMGSSVLGMNDIYRTWRAFVLRVR-ALDQTPRMYFVKADVTGAYDAIPQGKLVEVVANMIRHSE-STYCIR
Rattus norvegicus
GLRPIVNMSYGM---DTRAFGKKKQTQCFTQSLKTLFSVLNYERTKHPNLMGASVLGTSDSYRIWRTFVLRVR-ALDQTPRMYFVKADVTGAYDAIPQDKLVEIVANIIRRSE-SMYCIR
Canis familiaris GLRPIVNMDYIM---GARTFHRDKKVQHLTSQLKTLFSVLNYERARRPSLLGASMLGMDDIHRAWRTFVLRIR-AQNPAPQLYFVKVDVTGAYDALPQDRLVEVIANVIRPQE-STYCVR
Bos taurus GLRPIVNVGCVE---GAPAPPRDKKVQHLSSRVKTLFAVLNYERARRPGLLGASVLGMDDIHRAWRAFVLPLR-ARGPAPPLYFVKVDVVGAYDALPQDKLAEVIANVLQPQE-NTYCVR
Coturnix japonica
GLRPIVRLSRVVEGQKLSKESREKKIQRYNTQLKNLFSVLNYERTVNTSIIGSSVFGRDDIYRKWKEFVTKVFESGGEMPHYYFVKGDVSRAFDTIPHKKLVEVISQVLKPESQTVYGIR
Gallus gallus GLRPVVRLSRVVEGQKLSKESREKKIQRYNTQLKNLFSVLNYERTVNTSIIGSSVFGRDDIYRKWKEFVTKVFESGGEMPHFYFVKGDVSRAFDTIPHKKLVEVISQVLKPESQTVYGIR
Xenopus laevis GLRPISKISSTL-SSQQSKENQEKKIHHFSSQIRNLFSVLNYEWNRNCSLIGSSVFGMDDIYKKWKKFVLDFEKPQVEKLQFYFVKTDVKGAYDTIPHSKLDEVISKVINPNANEVYCIR
Oryzias latipes GMRPITRVIG-----------ADSNTRLHHKRIRDLMSMLQARVRSAPALLGSTVWGMTDIHKVLRSL