10 20
30
40 50
60
70 80
90
100
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120
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
|-NL--| |---TruB I---|
Homo sapiens
MADAEVII-LPKKHKKKKERK---SLPEEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFDKLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVE
Rattus norvegicus
MADAEAAMTFPKKHKKKKERK---PLPEADVAEIQHAEDFLIKPESKAAQLDTSQWPLLLKNFDRLNVRTTHYTPIPCGSNPLKREIGEYVRTGFINLDKPSNPSSHEVVAWIRRILRVE
Mus musculus
MADAEVI-TFPKKHKKKKDRK---PLQEDDVAEIQHAEEFLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVE
Bos taurus
MADAEVLI-LPKKHKKKKERK---SLPEEAVAEIQHAEEFLIKPESRVAQLDTSQWPLLLKNFDKLNVRTTHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVE
Gallus gallus
MADGDG---SSVKKRRKKDKR---SLPDEDVADIQHTEEFLIKPESRVAQLDTSQWPLLLKNFDKLNVLTTHYTPLPSGANPLKREISDYVRSGFINLDKPSNPSSHEVVAWIRRILRVE
Danio rerio
MADTES-----KKEKKRKSKK----ISDEEVGDIQESGDFLIKPESKVASLDTSQWPLLLKNFDKLNIRTAHYTPLPHGSNPLKRGIHDYVRSGFINLDKPANPSSHEVVAWIKRILRVE
Drosophila melanogaster MADVEV-----RKEKKKKKIKEEP-LDGDDIGTLQKQGNFQIKPSSKIAELDTSQWPLLLKNFDKLNIRSNHYTPLAHGSSPLNRDIKEYMKTGFINLDKPSNPSSHEVVAWIKKILKVE
Anopheles gambiae
MEVDI-PTSPIKKEKKKKKIKQEPDTEIENLGEIQKSGDFQLKPSSAIASLDTSKWPLLLKNFDRLNVRTNHYTPLPFGSSPLNRKINDYVSAGFINLDKPSNPSSHEVVAWIKRILKVN
Aedes aegypti
MSDYEMGSPTIKKEKKKKKIKQEPGAEIENLGEIQKSGNFQIQPSAAIAKLDTSQWPLLLKNFDRLNVRTNHYTPLPFGSSPLNRKIKDYVTSGFINLDKPSNPSSHEVVAWIKKILKVD
Culex pipiens quinquefasciatus MG-----SPHIKKEKKKKKIKQEPGVEVENLGEIQKSGDFQIKPSEAIAKLETSKWPLLLKNFDRLNVRTNHYTPLPFGSSPLNRKIKDYVTSGFINLDKPSNPSSHEVVAWIKKILKVE
Caenorhabditis elegans MG---------KKDKRSK-------LEGDDLAEAQQKGSFQLPSSNETAKLDASQWPLLLKNYDKLNVRTNHYTPHVEGVSPLKRDIKNYISSGFFNLDKPSNPSSHEVVSWIKRILRCE
Schizosaccharomyces pombe MTD-----------------------------THPGVDFMIKPEATSASKIDTAEWPLLLKNFDKLLVRTGHYTPIPCGNNPLKRPIAEYVSSGVINLDKPANPSSHEVVAWVKKILRVE
Saccharomyces cerevisiae MSK----------------------------------EDFVIKPEAAGASTDTSEWPLLLKNFDKLLVRSGHYTPIPAGSSPLKRDLKSYISSGVINLDKPSNPSSHEVVAWIKRILRCE
Kluyveromyces lactis MS-----------------------------------DEFVIKPESVSPSSNTSEWPLLLKDYDKLLVRSGHYTPIPAGASPLKRDLKSYISSGVINLDKPSNPSSHEVVAWIKRILRCE
Ashbya gossypii
MS-----------------------------------EEHMIKPENVAPSADTSEWPLLLKNYDKLLVRSGHYTPIPAGASPLKRDLKSYVSSGVINLDKPSNPSSHEVVAWIKRILRCE
Lodderomyces elongisporus MSK----------------------------------EDFQIKPEAVTPANNTSDWPLLLKNYDKLLVRSGHYTPIPAGSSPNNRDLKSYVSSGVINLDKPSNPSSHEVVAWIKRILRVE
Pichia stipitis
MS-----------------------------------DEYFIKPEAVSPSNDTSEWPLLLKNFDKLLVRSGHYTPIPSGSSPLKRDIKSYISSGVINLDKPSNPSSHEVVAWIKRILRSE
Pichia guilliermondii MAPHDAMRIF------------LNTIIVVFIFPVAMSDEYMIKPESIAPSNDTSEWPLLLKNFDKLLVRSGHYTPIPAGSSPLKRDLKSYVSSGVINLDKPSNPSSHEVVAWIKRILRTE
Zygosaccharomyces rouxii MSK-----------------------------------DFVIKPDTSGPTPDTAEWPLLLKDYDKLLMRSGHYTPIPAGSSPGKRDIKSYVNSGVINLDKPSNPSSHEVVAWIKRILRCE
Aspergillus fumigatus MAV----------------------------SVTKEEMDYTIKPEAGASNISTEDWPLLLKNYDKLMVRTGHFTPIPAGCSPLKRDLKSYISSGVINLDKPSNPSSHEVVAWMKRILRAE
Aspergillus clavatus MAV----------------------------ALAKEEMDYTIKPEAGASNISTEEWPLLLKNYDKLLVRTGHFTPIPAGCSPLKRDLKSYVSSGVINLDKPSNPSSHEVVAWMKRILRAE
Aspergillus nidulans M---------------------------------AKEVDYTIKPEATASNINTEDWPLLLKNYDKLMVRTGHFTPIPAGSSPLKRDLKSYINSGVINLDKPSNPSSHEVVAWMKRILRAE
Chaetomium globosum M----------------------SDSKALVKKGEDNEVEYMIKPQTLVPTLNTSDWPLLLKNYDKMLVRSGHFTPIPNGSSPYKRDIKSYVSSGVINLDKPSNPSSHEVVAWLKRMLRVE
Magnaporthe grisea MGG-------------------NKDALALARRDEEVDEEFSIKPEQVTPALDTSSWPLLLKNYDKLHIRTGHFTPIPNGSTPLRRDIKSYISSGVINLDKPSNPSSHEVVAWIKRILRCE
Neurospora crassa
MG---------------------------------AETEHVIKPQATEPAVDTSEWPLLLKNYSNLLVRTGHFTPIPAGSSPSKRDIKSYVSSGVINLDKPSNPSSHEVVAWIKRMLRVE
Botryotinia fuckeliana MALV--------------------------STKKEQEVDYTIKPEALTPAVDTSSWPLLLKNYNNLLVRTGHFTPIPNGCTPLKRDLKSYISSGVINLDKPSNPSSHEVVAWVKRMLRVE
Pyrenophora tritici-repentis MALV-----------------------------QTDPDAYVIKPAAAAPAIDTSDWPLLLKNYSDLLVRTSHYTPIPNGCAPLSRDLKSYISSGVINLDKPSNPSSHEVVSWIKRMLRVE
Neosartorya fischeri MAV----------------------------SVAKEEMDYTIKPEAGASNISTEEWPLLLKNYDKLMVRTGHFTPIPAGCSPLKRDLKSYISSGVINLDKPSNPSSHEVVAWMKRILRAE
Coccidioides immitis MAA------------------------------SKSDMDFSIKPEAATPPIPTSEWPLLLKNYDKLLVRTGHFTPIPAGCTPLKRDLKSYISSGVINLDKPSNPSSHEVVAWMKRILRVE
Dictyostelium discoideum MTT--------------------DKKSKSKSSEKSTQEVEQVIKPEKTPILDTSKWPLLLKNYDQLSVRTGHYTPIPNGHSPLKRPIKEYVKYGIINLDKPSNPSSHEVVAWIRTILRVT
Arabidopsis thaliana MAEVDI-------------SHSKKKKQDKTENDAADTGDYMIKPQSFTPAIDTSQWPILLKNYDRLNVRTGHYTPISAGHSPLKRPLQEYIRYGVINLDKPANPSSHEVVAWIKRILRVE
Chlamydomonas reinhardtii MSV----------------------------GEAQQRTDFLIQPEKTVPKLDTSKWPLLLKNYDKLNVRTGHYTPIPAGSTPLKRPLKEYLSYGCINLDKPANPSSHEVVAWVKRMLRVE
Cryptosporidium parvum SSM---------------------GKRKELEEMSDGKIETVIKPESKSQPIDTSNWPLLLKNYSKLNVRTGHYTPLPYGNSPLNRNLADYLSYGIINLDKPANPSSHEVVAWIKKILRCE
Euglena gracilis
MAKA----------------------------QWENDFSIPTESGEKGAALDSSEWPLLLKNYDKLNVRSAHYTPIPQGHTPLKRPIKAYLQYGCLNLDKPSNPSSHEVVSWLKRILKVE
Methanocaldococcus jannaschii MILLE------------------------------------------------KTQEKKINDKEELIVKEEVETNWDYGCNPYERKIEDLIKYGVVVVDKPRGPTSHEVSTWVKKILNLD
130
140
150
160
170
180
190
200
210
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230
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....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
|---TruB II--|
Homo sapiens
KTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEG-GTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGL
Rattus norvegicus
KTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGVVRLHNAIEG-TAQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESRVVEYDPERRLGVFWVSCEAGTYIRTLCVHLGL
Mus musculus
KTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEG-GTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGL
Bos taurus
KTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEG-GTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGL
Gallus gallus
KTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIES-EAQLARAIETLTGALFQRPPLIAAVKRQLRVRTIYESKLVEYDPERRLGIFWVSCEAGTYIRTLCVHLGL
Danio rerio
KTGHSGTLDPKVTGCLIVYVERATRLVKSQQSAGKEYVGIVRLHNALEN-EHQLARALECLTGALFQRPPLIAAVKRQLRVRTIYESKLIEYDPERRLGIFWVSCEAGTYIRTLCVHLGL
Drosophila melanogaster KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAIFKLHGAVES-VAKVRQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDETRNMGVFWVSCEAGSYIRTMCVHLGL
Anopheles gambiae
KTGHSGTLDPKVTGCLIVCINRATRLVKSQQSAGKEYVAVFKLHSAVEK-IAKVTQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYNDQRNIGVFWVSCEAGSYIRTMCVHLGL
Aedes aegypti
KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAVFKLHSAVES-VAKVNQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDDQRNMGVFWVSCEAGSYIRTMCVHLGL
Culex pipiens quinquefasciatus KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAVFKLHSAVES-VAKVNQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDDQRNMGVFWVSCEAGSYIRTMCVHLGL
Caenorhabditis elegans KTGHSGTLDPKVSGCLIVCIDRTTRLAKSQQGAGKEYICIFKLHEEVED-DRKVKQALEKLTGALFQRPPLISAVKRQLRIRTVYENKFIEYDPAQQMGIFNCICESGTYVRTICVHLGL
Schizosaccharomyces pombe KTGHSGTLDPKVTGCLIICNDRATRLVKSQQSAGKEYVCVLRLHDSVEG-ERNVASAIETLTGALFQRPPLISAVKRQLRIRSIYESKLIEFDNERNLAVFWASCEAGTYMRTLCVHLGL
Saccharomyces cerevisiae KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDALKD-EKDLGRSLENLTGALFQRPPLISAVKRQLRVRTIYESNLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGM
Kluyveromyces lactis KTGHSGTLDPKVTGCLIVCVDRATRLVKSQQGAGKEYVCIVRLHDALKD-EKELGRGLENLTGALFQRPPLISAVKRQLRVRTIYDSNLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGM
Ashbya gossypii
KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDALKD-EKDLGRELENLTGALFQRPPLISAVKRQLRVRTIYDSKLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGM
Lodderomyces elongisporus KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDQLEE-PKELNRALENLTGALFQRPPLISAVKRQLRVRTVYDSKLIEFDNKRGLGVFWASCEAGTYMRTLCVHLGM
Pichia stipitis
KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHEELKD-AKDLGRSLENLTGALFQRPPLISAVKRQLRVRTIYDSNLIEFDNKRGLGVFWASCEAGTYMRTLCVHLGM
Pichia guilliermondii KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDELKD-AKDMGRSLENLTGALFQRPPLISAVKRQLRVRTIYDSNLIEFDNKRGLGVFWASCEAGTYMRTLCVHLGM
Zygosaccharomyces rouxii KTGHSGTLDPKVTGCLIVCVDRATRLVKSQQGAGKEYVCIVRLHDALKD-EKDLGRSLESLTGALFQRPPLISAVKRQLRVRTIYDSNLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGM
Aspergillus fumigatus KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFKRALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL
Aspergillus clavatus KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFKRALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNERHLGVFWVSCEAGTYIRTLCVHLGL
Aspergillus nidulans KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFKRALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNERHLGVFWVSCEAGTYIRTLCVHLGL
Chaetomium globosum KTGHSGTLDPKVTGCLIVCIDRATRLVKAQQGAGKEYVAVVRFHDTIPGGEPAFAKALETLTGALFQRPPLISAVKRQLRIRTIHESKLIEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL
Magnaporthe grisea KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKVPGGEPEFARALETLTGALFQRPPLISAVKRQLRIRTIHESKLIEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL
Neurospora crassa
KTGHSGTLDPKVTGCLIVCVDRATRLVKAQQGAGKEYVCVIRFHDSVPGGEAAFASALETLTGALFQRPPLISAVKRQLRIRSIYESKLIEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL
Botryotinia fuckeliana KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKLPGGEAQFARALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL
Pyrenophora tritici-repentis KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKLPGGEAQFARALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNERQLGVFWVSCEAGTYIRTLCVHLGL
Neosartorya fischeri KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFKRALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL
Coccidioides immitis KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFARALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL
Dictyostelium discoideum KTGHSGTLDPKVTGCLIVCIERATRLVKSQQGAGKEYIGIVRLHGAIEG-TTELSKAVDTLTGALFQRPPQKSAVKKRLRVRTIHNSKLLEFDPERNLGLIWVDCEAGTYIRTLCVHIGL
Arabidopsis thaliana KTGHSGTLDPKVTGNLIVCIDRATRLVKSQQGAGKEYVCVARLHSAVP-DVAKVARALESLTGAVFQRPPLISAVKRQLRIRTIYESKLLEYDADRHLVVFWVSCEAGTYIRTMCVHLGL
Chlamydomonas reinhardtii KTGHSGTLDPKVTGNLIVCIDRATRLVKAQQAAGKEYVCIARFHGKVEGGTAAVNKALETLTGALFQRPPLISAVKRQLRVRTIYQAKLYEYDEERHLAVFWISCEAGTYVRTLCVHLGL
Cryptosporidium parvum KTGHSGTLDPKVTGCLLVCLNRATRLVKSQQSAGKEYVCIVRFHSSVGG-KSAVSRCLETLTGALFQRPPVISAVKRQLRVRSIYDSKLLDYDEKRNLAVFWAKCEAGTYIRTMCVHMGL
Euglena gracilis
KTGHAGTLDPKVTGSLLICIERATRLVKSQQNAGKEYVGVLRLHDALKD-EAQLLKALEDLTGAVFQRPPVVAAVKRTLRIRTIYESKLLDFDNDRHLAVFWISCEAGTYVRTLCVHLGF
Methanocaldococcus jannaschii KAGHGGTLDPKVTGVLPVALERATKTIPMWHIPPKEYVCLMHLHRDASE--EDILRVFKEFTGRIYQRPPLKAAVKRRLRIRKIHELELLDKDGKD--VLFRVKCQSGTYIRKLCEDIGE
250
260
270
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|---------------------------------------PUA domain-------
Homo sapiens
LLGVGGQMQELRRVRSGVMSEK--DHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRY---------EDGIEVNQEIVVITTKGEAIC
Rattus norvegicus
LLGVGGQMQELRRVRSGVVGER--DHMVTMHDVLDAQYLYDHHRDESYLRRVVFPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRY---------EDGIEVNQEVVVITTKGEAVC
Mus musculus
LLGVGGQMQELRRVRSGVMSEK--DHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRY---------EDGIEVNQEIVVITTKGEAIC
Bos taurus
LLGVGGQMQELRRVRSGVMSEK--DHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRY---------EDGIEVNQEIVVITTKGEAIC
Gallus gallus
LLGVGGQMQELRRVRSGILGEM--DNMVTMHDVLDAQWQYDNNKDDSYLRRVILPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRY---------EDGIELKQEIVVITTKGEAIC
Danio rerio
LLGVGGQMQELRRVRSGVLGEK--DNLVTMHDVLDAQWQFDHNKDETYLRRVIFPLEKLLISHKRIVMKDSAVNAICYGAKIMLPGVLRY---------EDGIEVNQDIVVITTKGEAIC
Drosophila melanogaster VLGVGGQMLELRRVRSGIQSER--DGMVTMHDVLDAMWLYENHKDESMLRRVIKPLEGLLVNHKRIIMKDSSVNAVCYGAKITLPGVLRY---------EDGIEIDQEIVICTTKGEAIC
Anopheles gambiae
VLGVGGQMLELRRVRSGIQSEK--DGMVTMHDVLDAQYLYENHKDESMLRRVIKPLEGLLVGHKRIIMKDSSVNAVCYGAKILLPGVLRY---------EDGIEIDQEIVIVTTKGEAIA
Aedes aegypti
VTGVGGQMLELRRVRSGIQSEK--DGMVTMHDVLDAQYLYDNHKDETMLRRVIKPLEGLLVGHKRIIMKDSSVNAVCYGAKIMLPGVLRY---------EDGIEMDQEIVIVTTKGEAVA
Culex pipiens quinquefasciatus VTGVGGQMLELRRVRSGIQSEK--DGMVTMHDVLDAQYLYENHKDESMLRRVIKPLEGLLIGHKRIIMKDSSVNAVCYGAKIMIPGVLRY---------EDGIEVDQEIVIVTTKGEAIA
Caenorhabditis elegans ILGCGGQMQELRRNRSGICDEN--ENMVTMHDVLDAQYLLDTQKDESYMRHIVRPLEALLTQHKRVVVKDSCINAICYGAKILIPGILRY---------DDDIEVGKEIVIMSTKGEAIC
Schizosaccharomyces pombe LLGVGGHMQELRRVRSGCLSEN--DDIVTMHDVLDAQWIYDNTRDESYLRRVIRPLESLLVGYKRIVVKDSAVNAICYGAKLMIPGLLRY---------EAGIEVNEEIVLITTKGEAIA
Saccharomyces cerevisiae LLGVGGHMQELRRVRSGALSEN--DNMVTLHDVMDAQWVYDNTRDESYLRSIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRY---------EEGIELYDEIVLITTKGEAIA
Kluyveromyces lactis LLGVGGHMQELRRVRSGALSEN--DNLVTLHDVMDAQWVYDNTRDESYLRKIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRY---------EEGIELYDEVVLITTKGEAIA
Ashbya gossypii
LLGVGGHMQELRRVRSGALDEN--DNMVTLHDVLDAQWVYDNTRDESYLRKIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRY---------EEGIELYDEVVLITTKGEAIA
Lodderomyces elongisporus LLGVGGHMQELRRVRSGAMSES--DNLVTLHDVLDAQYVYDNTRDESYLRKIIQPLETLLVGYKRLVVKDSAVNSVCYGAKLMLPGLLRY---------ESGIELYDEVVLITTKGEAIA
Pichia stipitis
LLGVGGHMQELRRVRSGALGEN--DNLVTLHDVLDAQYVYDNTRDESYLRKIIQPLETLLVGYKRIVVKDSAVNSVCYGAKLMIPGLLRY---------EEGIELYDEVVLMTTKGEAIA
Pichia guilliermondii LLGVGGHMQELRRVRSGALAEN--DNLVTLHDVLDAQYVYDNTRDESYLRKIIQPLETLLVGYKRIVVKDSAVNSVCYGAKLMIPGLLRY---------EEGIELYDEVVLITTKGEAIA
Zygosaccharomyces rouxii LLGVGGHMQELRRVRSGALSEN--DNLVTLHDILDAQWVYDNTRDESYLRRVIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRY---------EDGIELYDEVVLITTKGEAIA
Aspergillus fumigatus LLGVGAHMQELRRVRSGAMDEN--NGLVTLHDVLDAQWMYDNQRDESYLRRVIQPLESLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRF---------EAGIEVNEEVVLMTTKGEAIA
Aspergillus clavatus LLGVGAHMQELRRVRSGAMDEN--NGLVTLHDVLDAQWMYDNQRDESYLRRVISPLESLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRF---------EAGIDVNEEVVLMTTKGEAIA
Aspergillus nidulans LLGVGAHMQELRRVRSGAMSEN--EGMVTLHDVLDAQWLYDNQRDESYLRKVIKPLESLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRFGQKSLTWGLEAGIELGEEVVLMTTKGEAIA
Chaetomium globosum LLGVGAHMQELRRVRSGVMSED-NGSLVTLHDVLDAQWQYDNGGDESYLRKVIQPLETLLCTYKRLVVKDSAVNAVCYGAKLMLPGLLRY---------DAGIDAHEEVVLMTTKGEAIA
Magnaporthe grisea MLGVGAHMQELRRVRSGAMDET--KDLHTLHDVLDAQWLMDNTRDESYLRKVIQPLETLLTTYKRLVVKDSAVNAVCYGAKLMLPGLLRY---------EADIELHEEVVLMTTKGEAIA
Neurospora crassa
LLGVGAHMQELRRVRSGIMSED-NGSMVTLHDVLDAQWQFDNGGDETALRKVIQPLETLLTTYKRIVVKDSAVNAVCYGAKLMLPGLLRF---------EKGIETHEEVVLMTTKGEAIA
Botryotinia fuckeliana LLGVGAHMQELRRVRSGAMDET--KDMVTLHDVLDAQWMQDNARDEAYLRKVIQPLETLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRY---------EADIEVHEEVVLMTTKGEAIA
Pyrenophora tritici-repentis LLGVGAHMQELRRVRSGAMDET--KDLVTLHDVLDAQWLHDNNRDEAYLRKVIAPLESLLMSYKRIVVKDSSVNAICYGAKLMLPGLLRF---------EKGIEIHEEVVLMTTKGEAIA
Neosartorya fischeri LLGVGAHMQELRRVRSGAMDEN--NGLVTLHDVLDAQWMYDNQRDESYLRRVIRPLESLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRF---------EAGIDVNEEVVLMTTKGEAIA
Coccidioides immitis LLGVGAHMQELRRVRSGAMDEQ--DGMVTLHDVLDAQWMMDNNRDESYLRRVVRPLETLLTTYKRVVVKDSAVNAVCYGAKLMIPGLLRF---------EAGIEVHEEVVLMTTKGEAIA
Dictyostelium discoideum LMGVGGHMQEL