Other component sequences
Telomerase-associated proteins regulate telomerase activity and biogenesis of the ribonucleoprotein. Included are both telomerase reverse transcriptase (TERT) and telomerase RNA (TR) associated proteins. A standard nomenclature is used throughout the online database for consistency and clarity. Homologous proteins are given a single name for simplicity. Below are details on the interaction and fuction of each associated protein, the genbank accession numbers are linked to the record at the National Center for Biotechnology Information (NCBI), and original literature citations that are linked to the published online journal. The sequences are organized by taxon. Information within the table is derived from Cristofari, Lingner, et al (2006). Telomeres, 2nd edn. Cold Spring Harbor. Cold Spring Harbor Laboratory.
Vertebrates Component Interaction Function Remarks Genbank ID References
mammals
Homo sapiens (human) hEst1A telomerase activity (IP) telomere elongation telomere capping sequence similarities with budding yeast Est1 AY145883
hEst1B telomerase activity (IP) n.d. sequence similarities with budding yeast Est1 AY168922
hGar1p hTR (bandshift/UV cross-link) TR stability RNP assembly NM_032993
hNhp2 hTR (bandshift/UV cross-link) TR stability RNP assembly NM_017838 Pogacic et al, 2000
hNop10 hTR (bandshift/UV cross-link) TR stability RNP assembly NM_018648
dyskerin hTR (IP, UV cross-link) TR stability RNP assembly mutated in X-linked form of dyskeratosis congenita NM_001363
SMN telomerase activity (IP) RNP assembly? Nucleolar localization of hTERT
AAH62723 (SMN1)
NP_075013 (SMN2)
Bachand et al, 2002
14-3-3 hTERT (2-hybrid, IP) nuclear localization of hTERT Seimya et al, 2000
Ku telomerase activity (IP) hTR (bandshift, IP) n.d.
La hTR (UV cross-link, IP) n.d. Ford et al, 2001
Nucleolin telomerase activity (IP) nucleolar localization of hTERT NM_005381 Khunts et al, 2004
PinX1 TERT (IP) inhibitor of telomerase activity found in 2-hybrid screen with Pin2/TRF1
Hsp90 hTERT (IP, 2-hybrid) RNP assembly in vivo and in vitro
Hsp23 hTERT (IP, 2-hybrid) RNP assembly in vivo and in vitro
KIP hTERT (2-hybrid) positive regulator of telomere length Lee et al, 2004
hnRNP A1 telomerase activity (IP) telomere elongation Labranche et al, 1998
hnRNP C1/C2 hTR (UV cross-link, IP) n.d. Ford et al, 2000
hnRNP D telomerase activity (IP) n.d. Eversole et al, 2000
L22 hTR (3-hybrid) n.d. Le et al, 2000
hStau hTR (3-hybrid) n.d. Le et al, 2000

  Fungi Component Interaction Function Remarks Genbank ID References
Saccharomycotina
Schizosaccharomyces pombe
(fission yeast)
SpEst1 telomere elongation telomere capping ortholog of yeast Est1 O74804 Beernink et al, 2003
Saccharomyces cerevisiae
(baker's yeast)
Est1p TLC1 (ever shorter telomeres genetic screen, IP) binding of Cdc13p mediating telomerase recruitment and binding of telomeric DNA (not required for telomerase activity in vitro) AAB67418
Est3p Est3p (ever shorter telomeres genetic screen, IP) telomere elongation in vitro (not required for telomerase activity in vitro) NP_012256
Ku TLC1 (allel-specific interactions, in vitro binding) telomere elongation and chromosome healing
NP_014011 (KU 70)
NP_013824 (KU 80)
Cdc13p Est1p (ever shorter telomeres genetic screen, IP) binding of Est1p (not required for telomerase activity in vitro) NP_010061
Sm proteins TLC1 (IP) TLC1 expression/stability and maturation
Q02260 (Sm D1)
P43321 (Sm D3)
Seto et al, 1999
PinX1/Gno1p Est2p (IP) inhibitor of Est2p-TLC1 assembly ortholog of human Pinx1 AF432905 Lin et al, 2004

  Ciliates Component Interaction Function Remarks Genbank ID References
Oligohymenophorea Tetrahymena thermophila p75 (TAP-TERT purification) n.d. AY522576 Witkin et al, 2004
p65 (TAP-TERT purification) TER stability and RNP assembly ortholog of E. aediculatus p43, contains a La Motif AY280524
p45 (TAP-TERT purification) n.d. AY280525 Witkin et al, 2004
p20 (TAP-TERT purification) n.d. AY522577 Witkin et al, 2004
Spirotrich Euplotes aediculatus p43 TR (copurification with telomerase activity and MS identification) TER stability? Stimulates telomerase activity in vitro ortholog of T. thermophila p65, contains a La motif AF307939