The telomerase reverse transcriptase (TERT) is the essential protein component of the telomerase ribonucleoprotein. TERT is composed of three domains, a central RT domain where nucleotide transfer occurs, N-terminal extension (NTE) that contains RNA-interaction domains 1 and 2 (RID1 and RID2), and C-terminal extension (CTE) for processivity and localization. The reverse transcriptase is less divergent than the RNA component of telomerase. Below are details on the TERT sequences, the scientific and common name where applicable, the length and GC content for the cDNA; the length, the isoelectric point (pKI), the molecular weight, and the sequence (.seq button) for the amino acid sequences; the genbank accession numbers are linked to the record at the National Center for Biotechnology Information (NCBI), and original literature citations that are linked to the published online journal. The sequences are organized by taxon.
| Vertebrates | Length
(nt) |
GC % |
Length
(a.a.) |
pKi |
MW
(kd) |
Genbank ID | References | ||
|---|---|---|---|---|---|---|---|---|---|
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Homo sapiens (human) | 3399 |
66.08 |
1132 |
10.52 |
127.0 |
NM_198253 | ||
| Pan troglodytes (chimpanzee) | 3372 |
XM_001141571 (predicted) | (unpublished) | ||||||
3408 |
XM_001141663 (predicted) | (unpublished) | |||||||
3219 |
XM_526823 (predicted) | (unpublished) | |||||||
| Macaca mulatta (rhesus monkey) | 3210 |
XM_001096791 (predicted) | (unpublished) | ||||||
| Oryctolagus cuniculus (domestic rabbit) | 380 |
DQ399677 (TERT-like mRNA) |
(unpublished) | ||||||
| Mesocricetus auratus (golden Syrian hamster) | 3387 |
56.13 |
1128 |
10.21 |
128.4 |
AF149012 | Guo et al, 2001 | ||
| Mus musculus (mouse) | 3369 |
54.94 |
1122 |
9.64 |
127.9 |
AF051911 | Greenberg et al, 1998 | ||
| Rattus norvegicus (Norway rat) | 3378 |
56.25 |
1125 |
9.96 |
126.9 |
NM_053423 | Oh et al, 2001 | ||
| Canis familiaris (dog) | 3372 |
65.51 |
1124 |
10.41 |
124.8 |
AF380351 | Yazawa et al, 2003.2 | ||
| Felis catus (cat) | 237 |
AB094676 (partial sequence) |
Yazawa et al, 2003.1 | ||||||
| Bos taurus (cattle) | 3378 |
70.13 |
1126 |
10.7 |
124.4 |
NM_001046242 | (provisional) | ||
| Sus scrofa (pig) | 1842 |
AY785158 (partial sequence) |
(unpublished) | ||||||
| Monodelphis domestica (gray opossum) | 4089 |
XM_001369395 (predicted) | (unpublished) | ||||||
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Anas platyrhynchos (mallard duck) | 1842 |
DQ681293 (partial sequence) |
(unpublished) | |||||
| Coturnix japonica (Japanese quail) | 4035 |
45.38 |
1344 |
10.30 |
155.0 |
DQ681294 | (unpublished) | ||
| Gallus gallus (chicken) | 4041 |
45.4 |
1346 |
7.8 |
155.2 |
AY502592 | Delany et al, 2004 | ||
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Xenopus laevis (African clawed frog) | 3576 |
37.64 |
1191 |
10.3 |
138 |
AF212299 | Kuramoto et al, 2001 | |
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Oryzias latipes (Medaka) | 3273 |
57.78 |
1091 |
10.22 |
123.3 |
DQ248968 | Xie et al, 2008 | |
| Oryzias melastigma (Indian medaka) | 3261 |
54.77 |
1086 |
10.30 |
124.5 |
DQ286654 | Yu et al, 2006 | ||
| Epinephelus coioides (orange-spotted grouper) | 3297 |
55.69 |
1098 |
9.70 |
125.2 |
DQ317442 | Yu et al, 2006 | ||
| Takifugu rubripes (Fugu fish) | 3225 |
49.3 |
1075 |
10.3 |
122.5 |
AY861384 | Yap et al, 2005 | ||
| Tetraodon nigroviridis (green puffer fish) | 3012 |
CAAE01014577 (putative) |
(unpublished) | ||||||
| Danio rerio (zebrafish) | 3297 |
53.1 |
1098 |
9.98 |
126 |
EF202140 | Xie et al, 2008 | ||
| Invertebrates | Length
(nt)
|
GC % |
Length
(a.a.) |
pKi |
MW
(kd) |
Genbank ID | References | ||
|---|---|---|---|---|---|---|---|---|---|
| Ciona intestinalis (sea squirt) | 2724 |
38.07 |
907 |
9.80 |
105.3 |
EF077623 | Li et al, 2007 | ||
| Ciona savignyi (sea squirt) | 2532 |
34.44 |
843 |
10.61 |
99.3 |
EF514225 | Li et al, 2007 | ||
| Strongylocentrotus purpuratus (purple sea urchin) | 4068 |
1355 |
9.91 |
154.5 |
EF611988 (not yet available) |
(unpublished) | |||
3939 |
XM_776000 (predicted) | (unpublished) | |||||||
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Apis mellifera (honey bee) | 2406 |
21.32 |
801 |
9.58 |
96 |
NM_001040681 | Robertson et al, 2006 | |
| Bombyx mori (domestic silkworm) | 2112 |
29.5 |
704 |
9.90 |
83.7 |
DQ467676 | Osanai et al, 2006 | ||
| Bombyx mandarina (wild silkworm) | 2110 |
29.05 |
703 |
9.99 |
83.7 |
DQ467677 | Osanai et al, 2006 | ||
| Tribolium castaneum (red flour beetle) | 1791 |
39.42 |
597 |
9.91 |
70.4 |
NM_001040706 | Osanai et al, 2006 | ||
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Caenorhabditis elegans | 1686 |
34.99 |
561 |
10.65 |
65.8 |
NM_059972 | Meier et al, 2006 | |
1524 |
NM_059973 (N' truncation) |
||||||||
| Caenorhabditis remanei | 1692 |
38.18 |
564 |
10.65 |
66.9 |
DQ178631 | Meier et al, 2006 | ||
| Caenorhabditis briggsae | 1551 |
CAAC01000060 (hypothetical) |
Meier et al, 2006 | ||||||
| Fungi | Length
(nt)
|
GC % |
Length
(a.a.) |
pKi |
MW
(kd) |
Genbank ID | References | ||
|---|---|---|---|---|---|---|---|---|---|
| Schizosaccharomyces pombe (fission yeast) | 2970 |
34.48 |
909 |
9.96 |
116.5 |
AF015783 | Nakamura et al, 1997 | ||
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Saccharomyces cerevisiae (baker's yeast) | 2643 |
33.94 |
880 |
9.78 |
102.2 |
AM296251 | Liti et al, 2006 | |
| Saccharomyces kudriavzevii | 2631 |
34.82 |
876 |
9.51 |
101.7 |
AM296265 | Liti et al, 2006 | ||
| Saccharomyces bayanus | 2631 |
34.97 |
876 |
9.50 |
101.5 |
AM296250 | Liti et al, 2006 | ||
| Saccharomyces paradoxus | 2631 |
34.32 |
876 |
9.62 |
101.6 |
AM296271 | Liti et al, 2006 | ||
| Saccharomyces mikatae | 2637 |
33.56 |
878 |
9.34 |
101.8 |
AM296270 | Liti et al, 2006 | ||
| Kluyveromyces lactis | 2586 |
36.31 |
861 |
971 |
100.4 |
CR382123 | Dujon et al, 2004 | ||
| Candida albicans | 2604 |
35.25 |
867 |
10.02 |
100.8 |
XM_712533 | Jones et al, 2004 | ||
| Candida glabrata | 2556 |
XM_444808 (hypothetical) |
Dujon et al, 2004 | ||||||
| Debaryomyces hansenii | 2685 |
XM_458163 (hypothetical) |
Dujon et al, 2004 | ||||||
| Ashbya gossypii (Eremothecium gossypii) | 2562 |
44.69 |
853 |
9.16 |
98.9 |
NM_212177 | Dietrich et al, 2004 | ||
| Lodderomyces elongisporus | 2946 |
XM_001528127 (hypothetical) | (unpublished) | ||||||
| Pichia guilliermondii | 2637 |
XM_001482068 (hypothetical) | (unpublished) | ||||||
| Yarrowia lipolytica | 2823 |
XM_502732 (hypothetical) |
Dujon et al, 2004 | ||||||
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Aspergillus fumigatus | 3747 |
51.83 |
1248 |
10.30 |
142.8 |
XM_743958 | Nierman et al, 2005 | |
| Aspergillus oryzae | 2157 |
AP007151 (partial sequence) |
Machida et al, 2005 | ||||||
| Aspergillus clavatus | 3708 |
56.72 |
1235 |
7.80 |
139.3 |
XM_001273296 | (provisional) | ||
| Aspergillus niger | 3453 |
XM_001396218 (hypothetical) | Pel et al, 2007 | ||||||
| Aspergillus nidulans | 3609 |
XM_656265 (hypothetical) |
(unpublished) | ||||||
| Aspergillus terreus | 3561 |
XM_001213525 (hypothetical) | (unpublished) | ||||||
| Neosartorya fischeri | 3732 |
51.71 |
1243 |
10.30 |
141.5 |
XM_001261378 | (unpublished) | ||
| Coccidioides immitis | 3780 |
XM_001240369 (hypothetical) |
(unpublished) | ||||||
| Gibberella zeae | 3150 |
XM_381218 (hypothetical) |
(unpublished) | ||||||
| Magnaporthe grisea (rice blast fungus) | 3372 |
XM_363691 (hypothetical) |
Dean et al, 2005 | ||||||
| Chaetomium globosum | 2898 |
XM_001220720 (hypothetical) |
(unpublished) | ||||||
| Neurospora crassa | 2820 |
XM_958854 (hypothetical) |
Galagan et al, 2003 | ||||||
| Coprinopsis cinerea | 2190 |
AACS01000191 (hypothetical) |
(unpublished) | ||||||
| Ustilago maydis | 5796 |
XM_751815 (hypothetical) |
(unpublished) | ||||||
| Encephalitozoon cuniculi | 2472 |
45.27 |
823 |
9.70 |
95.3 |
XM_950490 | Katinka et al, 2001 | ||
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Dictyostelium discoideum | 3813 |
XM_628870 (hypothetical) |
Eichinger et al, 2005 | |||||
| Plants | Length
(nt)
|
GC % |
Length
(a.a.) |
pKi |
MW
(kd) |
Genbank ID | References | ||
|---|---|---|---|---|---|---|---|---|---|
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Arabidopsis thaliana (thale cress) | 3471 |
40.48 |
1124 |
10.30 |
130.6 |
AF135454 | Oguchi et al, 1999 | |
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Doryanthes excelsa (Gymea lily) | 3972 |
38.34 |
1323 |
9.50 |
152.4 |
AY790923 | Sýkorová et al, 2006 | |
| Hosta rectifolia (day lily) | 1772 |
AY850586 (partial sequence) |
Sýkorová et al, 2006 | ||||||
| Muscari armeniacum (grape Hyacinths) | 1498 | DQ073065 (partial sequence) |
(unpublished) | ||||||
| Ornithogalum virens (hyacinth) | 1051 |
AY850597 (partial sequence) |
Sýkorová et al, 2006 | ||||||
| Scilla peruviana (Peruvian jacinth) | 3684 |
AY818158 (partial sequence) |
Sýkorová et al, 2006 | ||||||
| Iris tectorum (Japanese roof Iris) | 3888 |
40.23 |
1295 |
10.11 |
147.6 |
DQ057997 | Sýkorová et al, 2006 | ||
| Phragmipedium longifolium | 2147 |
DQ073072 (partial sequence) |
(unpublished) | ||||||
| Oryza sativa (rice) | 3780 |
41.24 |
1260 |
9.88 |
143.7 |
AF288216 | Oguchi et al, 2004 | ||
| Hordeum vulgare (barley) | 786 |
AY363163 (partial sequence)
|
Sýkorová et al, 2006 | ||||||
| Zea mays (maize) | 3567 |
42.08 |
1188 |
10.02 |
136.0 |
AY818188 | Sýkorová et al, 2006 | ||
| Algae | Length
(nt)
|
GC % |
Length
(a.a.) |
pKi |
MW
(kd) |
Genbank ID | References | ||
|---|---|---|---|---|---|---|---|---|---|
| Galdieria sulphuraria (red algae) | 3315 |
38.10 |
1104 |
10.13 |
128.8 |
(unpublished) | |||
| Cyanidioschyzon merolae (red algae) | 2847 |
51.21 |
948 |
10.30 |
108.3 |
(unpublished) | |||
| Ostreococcus lucimarinus (green algae) | 2964 |
XM_001417260 (predicted) | (unpublished) | ||||||
| Ostreococcus tauri (green algae) | 3471 |
54.51 |
1156 |
10.38 |
129.5 |
CR954204 | Derelle et al, 2006 | ||
| Ciliates | Length
(nt)
|
GC % |
Length
(a.a.) |
pKi |
MW
(kd) |
Genbank ID | References | ||
|---|---|---|---|---|---|---|---|---|---|
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Tetrahymena thermophila | 3354 |
25.46 |
1118 |
9.65 |
133.2 |
AF062652 | Bryan et al, 1998 | |
| Paramecium tetraurelia | 2688 |
23.96 |
896 |
10.02 |
107.2 |
AF515460 | Ye et al, 2002 | ||
| Paramecium caudatum | 2688 |
24.33 |
895 |
9.92 |
107.1 |
AB035309 | Takenaka et al, 2001 | ||
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Euplotes aediculatus | 3096 |
32.36 |
1032 |
9.98 |
122.5 |
EAU95964 | Lingner et al, 1997 | |
| Euplotes eurystomus | 729 |
AY303935 (partial sequence) |
Möllenbeck et al, 2004 | ||||||
| Euplotes crassus (Moneuplotes crassus) | 3099 |
38.08 |
1032 |
10.30 |
123.3 |
AY267543 (micronuclear) | Karamysheva et al, 2003 | ||
3099 |
37.98 |
1032 |
10.17 |
122.8 |
AY267544 (macronuclear) | ||||
| Euplotes raikovi | 780 |
AY303932 (partial sequence) |
Möllenbeck et al, 2004 | ||||||
| Euplotes rariseta | 548 |
AY303936 (partial sequence) |
Möllenbeck et al, 2004 | ||||||
| Euplotes minuta | 700 |
AY303934 (partial sequence) |
Möllenbeck et al, 2004 | ||||||
| Euplotes vannus | 570 |
AY303933 (partial sequence) |
Möllenbeck et al, 2004 | ||||||
| Oxytricha trifallax(Sterkiella histriomuscorum) | 3399 |
32.6 |
1133 |
10.30 |
134 |
AF060230 | Bryan et al, 1998 | ||
| Other protists | Length
(nt)
|
GC % |
Length
(a.a.) |
pKi |
MW
(kd) |
Genbank ID | References | ||
|---|---|---|---|---|---|---|---|---|---|
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Plasmodium falciparum (human parasite) | 2385 |
AX112155 (partial sequence) |
|
Figueiredo et al, 2005 | ||||
| Plasmodium vivax (human parasite) | 7251 |
XM_001617019 (hypothetical) |
(unpublished) | ||||||
| Plasmodium knowlesi (monkey parasite) | (PlasmoDB) | Figueiredo et al, 2005 | |||||||
| Plasmodium berghei (rodent parasite) | (PlasmoDB) | Figueiredo et al, 2005 | |||||||
| Plasmodium chabaudi chabaudi (rodent parasite) | 2310 |
XM_737184 (hypothetical) |
Hall et al, 2005 | ||||||
| Plasmodium yoelii yoelii (rodent parasite) | 6336 |
XM_719577 (hypothetical) |
Figueiredo et al, 2005 | ||||||
| Theileria annulata | 3549 |
XM_950122 (partial sequence) |
Pain et al, 2005 | ||||||
| Cryptosporidium parvum | 4425 |
31.05 |
1475 |
10.10 |
170 |
AY034376 | (unpublished) | ||
| Cryptosporidium hominis | 4407 | XM_662704 (partial sequence) | Xu et al, 2004 | ||||||
| Toxoplasma gondii | 6309 |
AM055943 (hypothetical) |
Khan et al, 2006 | ||||||
| Giardia lamblia | 28883 |
45.47 |
960 |
9.97 |
109.7 |
XM_001709519 | Morrison et al, 2007 | ||
| Giardia intestinalis | 2883 |
45.44 |
961 |
10.00 |
109.7 |
AF195121 | Malik et al 2000 | ||
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Leishmania braziliensis | 3128 |
AY268078 (partial sequence) |
Giardini et al, 2006 | |||||
| Leishmania major | 3160 |
AY232305 (partial sequence) |
Giardini et al, 2006 | ||||||
| Leishmania donovani | 1392 |
AY780672 (partial sequence) |
Giardini et al, 2006 | ||||||
| Leishmania amazonensis | 4344 |
63.08 |
1448 |
10.23 |
157.5 |
AY232307 | Giardini et al, 2006 | ||
| Leishmania infantum | 4356 |
63.98 |
1451 |
10.32 |
157.6 |
XM_001469585 | (unpublished) | ||
| Trypanosoma cruzi | 3624 |
XM_814105 (partial sequence) |
El-Sayed et al, 2005 | ||||||
| Trypanosoma brucei | 3579 |
52.39 |
1192 |
10.30 |
132.5 |
AY904042 | Dreesen et al, 2005 | ||















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