Telomerase Database-TR sequences

The RNA component of telomerase (TR) contains the template that encodes the telomeric sequences and several other conserved regions that serve to bind the telomerase reverse transcriptase (TERT) that contains the active site for nucleotide addition and various other proteins that regulate telomerase activity. Despite the common purpose and conserved regions, the RNA component is quite divergent between species in size and structure. The size between species ranges from as short as 147 nucleotides in the ciliate, Tetrahymena paravorax to the fungi, Candida albicans at 1554 nucleotides. Below are details on the RNA component sequences, the scientific and common name where applicable, the length, the GC content, the nucleotide sequence (.seq button), the genbank accession numbers are linked to the record at the National Center for Biotechnology Information (NCBI), and original literature citations that are linked to the published online journal. The sequences are organized by taxon. The GC% content is not provided for putative/partial sequences. The GC% content has been adjusted, where necessary, to account for any adjustment to the 5' or 3' ends compared to the NCBI record, numbers in parentheses.

Vertebrates	Length (nt)	GC %	Genbank ID	References
Homo sapiens (human)	451	67.73	U85256/NR_001566	Feng et al, 1995
Tupaia glis belangeri (common tree shrew)	467	66.6	AF221912	Chen et al, 2000
Oryctolagus cuniculus (domestic rabbit)	451	68.51	AF221918	Chen et al, 2000
Cavia porcellus (domestic guinea pig)	421	66.27	AF221929	Chen et al, 2000
Chinchilla brevicaudata (short-tailed chinchilla)	447	66.22	AF221937	Chen et al, 2000
Geomys breviceps (gopher)	449	67.71	AF221930	Chen et al, 2000
Microtus ochrogaster (prairie vole)	399	62.16	AF221909	Chen et al, 2000
Cricetulus griseus (Chinese hamster)	382	65.45	AF221928	Chen et al, 2000
Mus musculus (mouse)	397	66.75	AF221922/NR_001579	Blasco et al, 1995
Mus spretus (western wild mouse)	397	65.24	AY058901	Hathcock et al 2002
Mus musculus castaneus (Asian house mouse)	397	66.75	AY058900	Hathcock et al 2002
Rattus norvegicus (Norway rat)	388	60.82	AF221916/NR_001567	Nozawa et al, 1999
Mustela putorius furo (domestic ferret)	443	66.37	AF221931	Chen et al, 2000
Procyon lotor (raccoon)	444	65.77	AF221917	Chen et al, 2000
Felis catus (cat)	446	65.47	AF221939	Chen et al, 2000
Bos taurus (cattle)	443	65.46	AF221936/NR_001576	Tsao et al, 1998
Muntiacus muntjak vaginalis (barking deer)	321		AY760074 (partial sequence)	Hartmann et al, 2005
Sus scrofa (pig)	541	66.91	AF221920	Chen et al, 2000
Sus scrofa (pig)	482	52.07	AF221942 (pseudo gene)	Chen et al, 2000
Suncus murinus (Asian house shrew)	451	66.3	AF221921	Chen et al, 2000
Equus caballus (domestic horse)	443	70.2	AF221925	Chen et al, 2000
Dasypus novemcinctus (armadillo)	450	66.44	AF221906	Chen et al, 2000
Dasyurus hallucatus (northern quoll)	508	73.23	AF221919	Chen et al, 2000
Elephas maximus (Asian elephant)	454	67.18	AF221932	Chen et al, 2000
Trichechus manatus (Caribbean manatee)	470	64.26	AF221923	Chen et al, 2000

Gallus gallus (chicken)	465	76.77	AF221938/NR_001594	Chen et al, 2000
Anodorhynchus hyacinthinus (macaw)	434	71.89	AF221924	Chen et al, 2000

Chelydra serpentina (snapping turtle)	410	72.44	AF221911	Chen et al, 2000

Bombina japonica (toad)	412	49.03	AF221913	Chen et al, 2000
Xenopus laevis (African clawed frog)	449	58.57	AF221908	Chen et al, 2000
Ceratophrys ornata (ornate horned frog)	405	56.79	AF221926	Chen et al, 2000
Pyxicephalus adspersus (bull frog)	397	59.19	AF221940	Chen et al, 2000
Dermophis mexicanus (Mexican caecilian)	445	59.78	AF221934	Chen et al, 2000
Herpele squalostoma (Congo caecilians)	444	60.36	AF221927	Chen et al, 2000
Typhlonectes natans (Rio Cauca caecilian)	443	57.79	AF221910	Chen et al, 2000

Oryzias latipes (Medaka)	312	51.28	EF569637	Xie et al, 2007
Nothobranchius furzeri (turquoise killifish)	133		FJ167673 (GRZ) (partial)	Hartmann et al, 2009
Nothobranchius furzeri (turquoise killifish)	133		FJ167674 (MZM-0403) (partial)	Hartmann et al, 2009
Gasterosteus aculeatus (stickleback)	348	54.02	EF680234	Xie et al, 2007
Takifugu rubripes (Fugu fish)	325	53.54	EF569638	Xie et al, 2007
Tetraodon nigroviridis (green puffer fish)	328	55.49	EF680233	Xie et al, 2007
Danio rerio (zebrafish)	317	48.90	EF569636	Xie et al, 2007
Rhizoprionodon porosus (sharpnose shark)	548	63.32	AF221915	Chen et al, 2000
Mustelus canis (smooth dogfish shark)	559	64.58	AF221933	Chen et al, 2000
Dasyatis sabina (Atlantic stingray)	478	60.25	AF221914	Chen et al, 2000
Rhinoptera bonasus (cownose ray)	491	59.27	AF221935	Chen et al, 2000

Fungi	Length (nt)	GC %	Genbank ID	References
Schizosaccharomyces pombe (fission yeast)	1207	35.63	EU239354	Leonardi et al, 2008 Webb and Zakian, 2008

Saccharomyces cerevisiae (baker's yeast) S288	1158	35.84	NC_001134 (11-1168)	Feldmann et al, 1994
Saccharomyces pastorianus (lager yeast)	1196	37.79	AY639014	Dandjinou et al, 2004
Saccharomyces kudriavzevii	1215	36.57	AY639012	Dandjinou et al, 2004
Saccharomyces cariocanus	1163	35.54	AY639010	Dandjinou et al, 2004
Saccharomyces bayanus	1219	36.75	AY639013	Dandjinou et al, 2004
Saccharomyces paradoxus	1161	35.06	AY639015	Dandjinou et al, 2004
Saccharomyces mikatae	1215	35.14	AY639011	Dandjinou et al, 2004
Kluyveromyces lactis	1326	40.27	U31465	McEachern et al, 1995
Kluyveromyces wickerhamii	1036	38.80	AY151281	Seto et al, 2002
Kluyveromyces nonfermentans	928	38.58	AY151280	Seto et al, 2002
Kluyveromyces marxianus	1516	37.86	AY151279 (118-1633)	Seto et al, 2002
Kluyveromyces dobzhanskii	1316	41.64	AY151278	Seto et al, 2002
Kluyveromyces aestuarii	933	37.83	AY151277	Seto et al, 2002
Candida albicans	1544	35.30	EF647866	Hsu et al, 2007
Candida glabrata	2491	36.05	NC_006032 (668084-670574)	Kachouri-Lafond et al, 2009

* The Genbank records have been adjusted for the 5’ and 3’ ends, numbers in parentheses.

Ciliates	Length (nt)	GC %	Genbank ID	References
Glaucoma chattoni	161	39.75	(no Genbank ID available)	Romero et al, 1991
Glaucoma sp. ME60q	162	38.27	AF417612	Ye et al, 2002
Tetrahymena thermophila	159	33.96	AF399707	Greider and Blackburn, 1989
Tetrahymena malaccensis	159	33.96	(no Genbank ID available)	Romero et al, 1991
Tetrahymena pyriformis	159	33.33	(no Genbank ID available)	Romero et al, 1991
Tetrahymena vorax	158	34.81	U22354	McCormick-Graham et al, 1995
Tetrahymena borealis	157	35.03	U22350	McCormick-Graham et al, 1995
Tetrahymena silvana	150	34.00	U22353	McCormick-Graham et al, 1995
Tetrahymena australis	159	33.33	U22349	McCormick-Graham et al, 1995
Tetrahymena pigmentosa	154	35.71	(no Genbank ID available)	Romero et al, 1991
Tetrahymena hyperangularis	153	35.95	(no Genbank ID available)	Romero et al, 1991
Tetrahymena capricornis	156	35.90	U22351	McCormick-Graham et al, 1995
Tetrahymena hegewischi	155	37.42	(no Genbank ID available)	Romero et al, 1991
Tetrahymena paravorax	147	40.14	U22352	McCormick-Graham et al, 1995
Colpidium striatum	161	38.51	AF417611	Ye et al, 2002
Colpidium colpoda	157	37.58	AF417610	Ye et al, 2002
Colpidium campylum	161	38.51	AF417609	Ye et al, 2002
Paramecium tetraurelia	205	36.10	U45433	McCormick-Graham et al, 1996
Paramecium primaurelia	205	36.59	U45434	McCormick-Graham et al, 1996
Paramecium primaurelia	205	29.27	U45435 (pseudo gene)	McCormick-Graham et al, 1996
Paramecium multimicronucleatum	201	34.33	U45436	McCormick-Graham et al, 1996
Paramecium caudatum	203	35.96	U45437	McCormick-Graham et al, 1996

Euplotes aediculatus	189	37.57	U10565	Lingner et al, 1994
Euplotes eurystomus	189	37.04	U10566	Lingner et al, 1994
Euplotes crassus	191	40.31	M33461	Shippen-Lentz et al, 1990
Oxytricha nova (Sterkiella nova)	190	47.37	U10567	Lingner et al, 1994
Oxytricha trifallax (Sterkiella histriomuscorum)	186	46.77	U10568	Lingner et al, 1994
Stylonychia mytilis	189	45.50	U10570	Lingner et al, 1994
Stylonychia lemnae	189	46.03	U10569	Lingner et al, 1994

Other Protists	Length (nt)	Genbank ID	References
Plasmodium falciparum (malaria parasite)	1084	AL929357 (96976-98058) (putative)	Chakrabarti et al, 2007
Plasmodium vivax (human parasite)	1304	(PlasmoDB) (putative)	Chakrabarti et al, 2007
Plasmodium knowlesi (monkey parasite)	1254	(PlasmoDB) (putative)	Chakrabarti et al, 2007
Plasmodium berghei (rodent parasite)	889	(PlasmoDB) (putative)	Chakrabarti et al, 2007
Plasmodium chabaudi chabaudi (rodent parasite)	827	(PlasmoDB) (putative)	Chakrabarti et al, 2007
Plasmodium yoelii yoelii (rodent parasite)	885	(PlasmoDB) (putative)	Chakrabarti et al, 2007
Plasmodium gallinaceum (chicken parasite)	716	(PlasmoDB) (putative)	Chakrabarti et al, 2007

* The Genbank records have been adjusted for the 5’ and 3’ ends, numbers in parentheses.

Viruses		Length (nt)	GC %	Genbank ID	References
MDV-1 (Marek’s disease alphaherpesvirus 1)	RB1B	442	73.53	AF331499 (160-601)	Coussens and Velicer, 1988 Tulman et al, 2000 Fragnet et al, 2003 Fragnet et al, 2005 Spatz and Silva, 2007
MDV-2 (Marek’s disease alphaherpesvirus 2)	GA	446	72.65	AF147806 (246-691)
	Md5	442	73.53	AF243438 (1676-2117)
	RM-1	442	73.53	EF526179 (3436-3877) (reverse complement)

* The Genbank records have been adjusted for the 5’ and 3’ ends, numbers in parentheses.