The RNA component of telomerase (TR) contains the template that encodes the telomeric sequences and several other conserved regions that serve to bind the telomerase reverse transcriptase (TERT) that contains the active site for nucleotide addition and various other proteins that regulate telomerase activity. Despite the common purpose and conserved regions, the RNA component is quite divergent between species in size and structure. The size between species ranges from as short as 147 nucleotides in the ciliate, Tetrahymena paravorax to the fungi, Candida albicans at 1554 nucleotides. Below are details on the RNA component sequences, the scientific and common name where applicable, the length, the GC content, the nucleotide sequence (.seq button), the genbank accession numbers are linked to the record at the National Center for Biotechnology Information (NCBI), and original literature citations that are linked to the published online journal. The sequences are organized by taxon. The GC% content is not provided for putative/partial sequences. The GC% content has been adjusted, where necessary, to account for any adjustment to the 5' or 3' ends compared to the NCBI record, numbers in parentheses.
| Vertebrates | Length
(nt) |
GC % |
Genbank ID |
References |
||
|---|---|---|---|---|---|---|
 |
Homo sapiens (human) | 451 |
67.73 |
|
||
| Tupaia glis belangeri (common tree shrew) | 467 |
66.6 |
||||
| Oryctolagus cuniculus (domestic rabbit) | 451 |
68.51 |
||||
| Cavia porcellus (domestic guinea pig) | 421 |
66.27 |
||||
| Chinchilla brevicaudata (short-tailed chinchilla) | 447 |
66.22 |
||||
| Geomys breviceps (gopher) | 449 |
67.71 |
||||
| Microtus ochrogaster (prairie vole) | 399 |
62.16 |
||||
| Cricetulus griseus (Chinese hamster) | 382 |
65.45 |
||||
| Mus musculus (mouse) | 397 |
66.75 |
||||
| Mus spretus (western wild mouse) | 397 |
65.24 |
||||
| Mus musculus castaneus (Asian house mouse) | 397 |
66.75 |
||||
| Rattus norvegicus (Norway rat) | 388 |
60.82
|
||||
| Mustela putorius furo (domestic ferret) | 443 |
66.37 |
||||
| Procyon lotor (raccoon) | 444 |
65.77 |
||||
| Felis catus (cat) | 446 |
65.47 |
||||
| Bos taurus (cattle) | 443 |
65.46 |
||||
| Muntiacus muntjak vaginalis (barking deer) | 321 |
AY760074 (partial sequence) |
||||
| Sus scrofa (pig) | 541 |
66.91 |
||||
482 |
52.07 |
AF221942 (pseudo gene) |
||||
| Suncus murinus (Asian house shrew) | 451 |
66.3 |
||||
| Equus caballus (domestic horse) | 443 |
70.2 |
||||
| Dasypus novemcinctus (armadillo) | 450 |
66.44 |
||||
| Dasyurus hallucatus (northern quoll) | 508 |
73.23 |
||||
| Elephas maximus (Asian elephant) | 454 |
67.18 |
||||
| Trichechus manatus (Caribbean manatee) | 470 |
64.26 |
||||
 |
Gallus gallus (chicken) | 465 |
76.77 |
|||
| Anodorhynchus hyacinthinus (macaw) | 434 |
71.89 |
||||
| Chelydra serpentina (snapping turtle) | 410 |
72.44 |
||||
 |
Bombina japonica (toad) | 412 |
49.03 |
|||
| Xenopus laevis (African clawed frog) | 449 |
58.57 |
||||
| Ceratophrys ornata (ornate horned frog) | 405 |
56.79 |
||||
| Pyxicephalus adspersus (bull frog) | 397 |
59.19 |
||||
| Dermophis mexicanus (Mexican caecilian) | 445 |
59.78 |
||||
| Herpele squalostoma (Congo caecilians) | 444 |
60.36 |
||||
| Typhlonectes natans (Rio Cauca caecilian) | 443 |
57.79 |
||||
 |
Oryzias latipes (Medaka) | 312 |
51.28 |
|||
| Gasterosteus aculeatus (stickleback) | 348 |
54.02 |
||||
| Takifugu rubripes (Fugu fish) | 325 |
53.54 |
||||
| Tetraodon nigroviridis (green puffer fish) | 328 |
55.49 |
||||
| Danio rerio (zebrafish) | 317 |
48.90 |
||||
| Rhizoprionodon porosus (sharpnose shark) | 548 |
63.32 |
||||
| Mustelus canis (smooth dogfish shark) | 559 |
64.58 |
||||
| Dasyatis sabina (Atlantic stingray) | 478 |
60.25 |
Chen et al, 2000 | |||
| Rhinoptera bonasus (cownose ray) | 491 |
59.27 |
Chen et al, 2000 | |||
| Fungi | Length
(nt) |
GC % |
Genbank ID |
References |
||
|---|---|---|---|---|---|---|
| Schizosaccharomyces pombe (fission yeast) | 1207 |
35.63 |
EU239354 | |||
 |
Saccharomyces cerevisiae (baker's yeast) S288 | 1158 |
35.84 |
NC_001134 (11-1168) |
||
| Saccharomyces pastorianus (lager yeast) | 1196 |
37.79 |
||||
| Saccharomyces kudriavzevii | 1215
|
36.57
|
||||
| Saccharomyces cariocanus | 1163
|
35.54
|
||||
| Saccharomyces bayanus | 1219
|
36.75
|
||||
| Saccharomyces paradoxus | 1161 |
35.06 |
||||
| Saccharomyces mikatae | 1215 |
35.14 |
||||
| Kluyveromyces lactis | 40.27 |
|||||
| Kluyveromyces wickerhamii | 1036 |
38.80 |
||||
| Kluyveromyces nonfermentans | 928 |
38.58 |
||||
| Kluyveromyces marxianus | 1516 |
37.86 |
AY151279 (118-1633) |
|||
| Kluyveromyces dobzhanskii | 1316 |
41.64 |
||||
| Kluyveromyces aestuarii | 933 |
37.83 |
||||
| Candida albicans | 1554 |
35.30 |
Hsu et al, 2007 | |||
* The Genbank records have been adjusted for the 5’ and 3’ ends, numbers in parentheses.
| Ciliates | Length
(nt) |
GC % |
Genbank ID |
References |
||
|---|---|---|---|---|---|---|
 |
Glaucoma chattoni | 161 |
39.75 |
(no Genbank ID available) | ||
| Glaucoma sp. ME60q | 162 |
38.27 |
||||
| Tetrahymena thermophila | 159 |
33.96 |
(unpublished) | |||
| Tetrahymena malaccensis | 159 |
33.96 |
(no Genbank ID available) | Romero et al, 1991 | ||
| Tetrahymena pyriformis | 159 |
33.33 |
(no Genbank ID available) | |||
| Tetrahymena vorax | 158 |
34.81 |
||||
| Tetrahymena borealis | 157 |
35.03 |
||||
| Tetrahymena silvana | 150 |
34.00 |
||||
| Tetrahymena australis | 159 |
33.33 |
||||
| Tetrahymena pigmentosa | 154 |
35.71 |
(no Genbank ID available) | |||
| Tetrahymena hyperangularis | 153 |
35.95 |
(no Genbank ID available) | |||
| Tetrahymena capricornis | 156 |
35.90 |
||||
| Tetrahymena hegewischi | 155 |
37.42 |
(no Genbank ID available) | |||
| Tetrahymena paravorax | 147 |
40.14 |
||||
| Colpidium striatum | 161 |
38.51 |
||||
| Colpidium colpoda | 157 |
37.58 |
||||
| Colpidium campylum | 161 |
38.51 |
||||
| Paramecium tetraurelia | 205 |
36.10 |
||||
| Paramecium primaurelia | 205 |
36.59 |
||||
205 |
29.27 |
U45435 (pseudo gene) |
||||
| Paramecium multimicronucleatum | 201 |
34.33 |
||||
| Paramecium caudatum | 203 |
35.96 |
||||
 |
Euplotes aediculatus | 189 |
37.57 |
|||
| Euplotes eurystomus | 189 |
37.04 |
||||
| Euplotes crassus | 191 |
40.31 |
||||
| Oxytricha nova (Sterkiella nova) | 190 |
47.37 |
||||
| Oxytricha trifallax (Sterkiella histriomuscorum) | 186 |
46.77 |
||||
| Stylonychia mytilis | 189 |
45.50 |
||||
| Stylonychia lemnae | 189 |
46.03 |
||||
| Other Protists | Length
(nt) |
GC % |
Genbank ID |
References |
||
|---|---|---|---|---|---|---|
 |
Plasmodium falciparum (malaria parasite) | 1084 |
AL929357 (96976-98058) (putative) |
|||
| Plasmodium vivax (human parasite) | 1304 |
(PlasmoDB) (putative) |
Chakrabarti et al, 2007 | |||
| Plasmodium knowlesi (monkey parasite) | 1254 |
(PlasmoDB) (putative) |
Chakrabarti et al, 2007 | |||
| Plasmodium berghei (rodent parasite) | 889 |
(PlasmoDB) (putative) |
Chakrabarti et al, 2007 | |||
| Plasmodium chabaudi chabaudi (rodent parasite) | 827 |
(PlasmoDB) (putative) |
Chakrabarti et al, 2007 | |||
| Plasmodium yoelii yoelii (rodent parasite) | 885 |
(PlasmoDB) (putative) |
Chakrabarti et al, 2007 | |||
| Plasmodium gallinaceum (chicken parasite) | 716 |
(PlasmoDB) (putative) |
Chakrabarti et al, 2007 |
* The Genbank records have been adjusted for the 5’ and 3’ ends, numbers in parentheses.
| Viruses | Length
(nt) |
GC % |
Genbank ID |
References |
|||
|---|---|---|---|---|---|---|---|
| MDV-1 (Marek’s disease alphaherpesvirus 1) | RB1B | 442 |
73.53 |
AF331499 (160-601) | |||
| MDV-2 (Marek’s disease alphaherpesvirus 2) | GA | 446 |
72.65 |
AF147806 (246-691) | |||
| Md5 | 442 |
73.53 |
AF243438 (1676-2117) | ||||
| RM-1 | 442 |
73.53 |
EF526179 (3436-3877)
(reverse complement) |
||||
* The Genbank records have been adjusted for the 5’ and 3’ ends, numbers in parentheses.
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