10 20
30 40
50 60
70 80
90
100
110
120
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
I
structures
((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((
Saccharomyces cerevisiae
GAGAGGAAGAUAGGUACCCUAUGAAAAUGUC-AAUGGCUGUUGCGUUUGCUUAAUCGUAUUUUUUUUUUUUUCAGUCCGU-GUUUUUUGUACAUUCUACGUUUGAGUUUUCCAUCAUGCA
Saccharomyces paradoxus CAAAGGAAGAUAGGUAACCUAUUAAAAUGUC-AGCGGCUGUUGCGUUUGCUUAGUUG--UUUUU-UUUU----AGUAUUUUUUU-UUUGUACGUUUUCCGUUUGAAUUUUCUAUCAUGCA
Saccharomyces kudriavzevii AUGAGG-AGGUCGGUUACCUAUUAAGAUGUC-CAUGGUCGUCACGUUUAGUUACUAGUAUUUUUUCUC--UUUUGUUUCU-GUUUUUUGUGCAUUUUCCAUUUGAGUUUUCUAUUGU-UG
Saccharomyces cariocanus
UAGAGGAAGAUAGGUAGCCUAUUAAAAUGUC-AGCGGCUGUCGCGUUUGCUUAGUUG--UUUUU-UUUU----AGUAUUUGUCG-UCUGUACAUUUUCCGUUUGAAUUUUCUAUCAUGCA
Saccharomyces bayanus GAGAGGAAGGU-AGUAACCUAAUAAUACGUC-AGCGACUGGUAUGUUUGCCUGCCCUUUUUUUA---------UUUUG-CUUGUCAAUGUAUUUUUUCCAUUUGAGUUUUCUGUUG-AUA
Saccharomyces pastorianus GAGAGGAAGGU-GGUAACCUAAUAACACGUC-AGCGACUGGUAUGUUUGCUUGCCCUUUUUUAA----------UUUG-CUUCUCAAUGUAUUUUUUCCAUUUGAGUUUUCUGUUG-AUA
Saccharomyces mikatae AUGAGGAAGAUGCGUCGCCUAUUAAAAUGUCUGGCGGCUGUUACAUUUGCUUUCUAGCACUUUUCUAU--UCUCGUUUCC-UUUUUUUGUACCUUCCCCUUUUGAAUUUUCCAUCGUAUA
(
130
140
150
160
170
180
190
200
210
220
230
240
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
IIa IIb I
structures
(((((((( (((((((((((((((((((((((((((((((((((((((((((((
((((((((((((((((((((((((((((((( )))))))))))
Saccharomyces cerevisiae
GGCCUCAGAAAUUUGGUAGGCACUCGAUGGUGAAGAGAUAGUGUCGGAUUUCGGAUUGAUCUUUCA-GUUGAUAGCCUGC-UGCUC--U----UUUCUUU------UCCAAAGAAUUUCG
Saccharomyces paradoxus AGCCUCAGAGAUUUGGUAGAUGCUUAAUGAUGUAAAGGUUGCGUUGAAUUUUGGAUUGUUCUCUCAAGUUAGCAGGCAG-GUGCAC--U----UUUCUCUUU----UACGAAGGACUUCG
Saccharomyces kudriavzevii AGCCUCAGAUAUUUGGUAGACGCUUAAUGGUGGAAUGAUUGGACCGGAUUUAGGGUUGUGUUCUCAGAUUGGCGGGCAGUUACACUGGUUGUUGUUUUUU------AACGAAGGGCUAUG
Saccharomyces cariocanus
AGCCUCAGAGAUUUGGUAGAUGCUUAAUGAUGUAGAGGUUGCGAUGAAUUUUGGAUUGUUCUCUCAAGUUAGCAGGCAG-GU-CAC--U----UUUCUCUUU----UACGAAGGACUUCG
Saccharomyces bayanus AGCCUCAGAGUUUUGGUAGGCGCCUAGUGGUGGAAUGGUUGGGCUGGAAUCGGAAUUGAGAUGUGAUGUUAACGGGCCAUCGUGCAU---------CUUUUUUAAAUUUUGAGCAAUUUG
Saccharomyces pastorianus AGCCUCAGAGUUUUGGUAGGCGCCUAGUGGUGGAACGGUUGAGCCGGAAUCGCGAUUGAGAUGUGAUG-----GGGCCAUUGUGCAU---------CUUUUUUAUAUUUUGGGCAAUGCG
Saccharomyces mikatae AGCCUCAGAAAUUUGGUAGACACUUAAUGAUGAAUAGGUUGGGUUAGAUUU-GAUUUGAGAUCUUGAGUCACCAGGCAGU-CCCA----------AUUUUUUU---UACGAAAUAUUAGG
(((((((( ((((((((
CS1 template boundary
250
260
270
280
290
300
310
320
330
340
350
360
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Ib IIb 1 IIc IIc
structures
)))))))))))))))) (((((( (((((((((((((((((((((((((((((((((((( ))))))))))))))))
Saccharomyces cerevisiae
AGUAUGCU-GGUGUCAGU-GUAGAUG-CUUGUGU-GUGCGCA-AUU-UGUGGUUUUUUAUUGUGUUUCUACUUAUAGAUGGCU-----------------AAAAUCUGAGUUUAGAAA-A
Saccharomyces paradoxus AGUGCACU-GGGGUCAGCAU-AGAUA-CUUGUGU-GUACGUAUAUU-UGUGGUUU-UUGUUAUUUUUCUACUUAUAGAUGGCU-----------------AAAAUCUGAGUUU-GAAAGA
Saccharomyces kudriavzevii AGUGCGCU-GGUGUCAGUGU-AGAUA-CAUAUG-UAUGCG--UACA-UGUGGUUU-UUGUUGUUCUUCUACUUAUAGAUCGCU-----------------AAAAUCUGAGUUU-GA-GAA
Saccharomyces cariocanus
AGUGCACU-GGGGUCAGCAU-AGAUA-CUUGUGU-GUACGUAUAUU-UGUGGUUU-UUGUUAUUUUUCUACUUAUAGAUGGCU-----------------AAAAUCUGAGUUU-GAAAGG
Saccharomyces bayanus AGUACGCUAG-UGCCACUAU-GCAUGUUUCAUG-UAUACAUGUAUG-CGCGGUUU-CUGUUCUUGUCGUACUUAUAGAUCGCUACGUUAUUUCAAUUUUGAAAAUCUGAGUCC-UGG-GA
Saccharomyces pastorianus AGCACGCUAG-UGCCA-------------------------GUAUG-CGCGGUUU-CUGUUC-----GUACUUAUAGAUCGCUACGUUAUUUCAUUUUUGAAAAUCUGAG-CC-CGGGGA
Saccharomyces mikatae AGUGUGCU-GAUGUCAGCAU-AGAUG--AUGUAUUAUACAUGUUUUGUGUGGUU---UGCUAUAUUUCUACUUAUAGAUGGCU-----------------AAAAUCUGAGUUU-GAGA-G
((((((((((((((((((((
)))))))))))))))))
Ku80 site Ku80 site
370
380
390
400
410
420
430
440
450
460
470
480
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
IId IId IId 1 IId 1 |IIb1||----------------------
structures
))))))))))))))))) (((((((((( )))))))))) (((((((((((((((((( ))))))))))))))) )))))))))))))))))))))))))))))
Saccharomyces cerevisiae
UGCA--AACCGUAAAUUCUUAAACACUGCUAUUGC-AUUUAGUUGCUAAAGCAGUGUUU--UUGAACUUAUUCCUGUUAUUCCUU--CUU-C-GUACCGAUCCUCUUCUC-GACCUAACC
Saccharomyces paradoxus UGGC--CACCAUAAAUUCUUAAAA-GUGGUAUCGC-AUUUAGCCCCC----------------------------------------CUU-C-GUACCAAUUCUGUUUUC-GUCUCAAGC
Saccharomyces kudriavzevii AUGCGGGACCAUCCAUGUCCGAAUAUAACUGACGC-AUUUUGUAGCUAGAACACGUUUU-UCCUA-CAA-UUA------UCCCGCUCCUCUUAG-AAAAAUUCUGCUUUC-ACUCCAA-C
Saccharomyces cariocanus
UGGC--CACUAUAAAUUCUUAAAAAGUGGCACCGC-AUUUAGCCCCC----------------------------------------CUU-C-GUACCGAUUCUGUUUUC-GUCUCAAGC
Saccharomyces bayanus GUGCGGAGCCAUGCAUACAUGUACUUUAUUGUUGCAUAGUAUU-GCUAGAGUACACUUU-CUCCAUGA--UUG---UCUGU-CUU--CUU-UA-CACCAGUUCUGUUUUCUGUCUUAACC
Saccharomyces pastorianus GUGCGGAUCCAUACAUACAUGUAAUUUGUUGUUGC--AGUAUU-GCUAGAGUACAUUUUUCUCCGCGA--UUG---UCUGU-CUU--CUU-UA-CACCAGUUCUGUUUUCCGUCUCAACC
Saccharomyces mikatae CAGCA-UGCCACAGAUGCUUGGAUUUUACUAUUGG-AUUUUGCUGCCGGAAUAGGGCUU-UCGGGACAC-UUA------UUCCUUUGCUUA-AG-ACCAACUCUGUUUUC-GCCUUUGCC
)))))))
490
500
510
520
530
540
550
560
570
580
590
600
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
----------------IIa---------------------|
template III III IVa
structures
)))))))))))))))))))))))))))))))))))))))))
||||||||||||||| (((((( )))))) (((((((((((((((((((((((((((((((((
Saccharomyces cerevisiae
UUUUAAUUACCAUG-----G-G---------AAGCCUACCAUCACCACACCCACACACAAAUGUUACAGCUAAUUGUUUAUUAGCAAAGUUUGCACGAGUUCGC-UGU-UUAUU-UUUUU
Saccharomyces paradoxus UCUUCAUUACUACA-----GCG--------CAAGUCUACCAUUACCACACCCACACACAGAUACCACGGCUAAU-GUUUAUUAGUUAAGUUUCCAUGAGCUCAC-UCU-UUAUUCUUUUC
Saccharomyces kudriavzevii UCUUCAUCA--UUU-----U-AUAAGAAUUU--GUCUACCAUUACCACACCCACACACAAACAUUACGGCUAGUAGUUUAUUAGUCAAAUUUCCAU-G-GCCACACAUUUUGUC-UUUUU
Saccharomyces cariocanus
UCUUCAUUACUACA-----GCG--------CAAGUCUACCAUUACCACACCCACACACAGAUAUUACGGCUAAU-GUUUAUUAGUCAAGUUUCCAUGAGCUCAC-UCU-UUAUUCUUUUU
Saccharomyces bayanus UCUUCACUA--UCAUGGAAA-G--------U--UUCUACCAUUACCACACCCACACACGAACAUUAAGGCUAAUCGUU-AUUAGUUCAAUCUCCAUA-----GC-CACAC-----UCUUU
Saccharomyces pastorianus UCUUCAUUA--UUAUGGAAA-G--------C--AUCUACCAUUACCACACCCACACACGAACGUUAAGGCUAAUCGUU-AUUAGUUGAAUCUCCAUA-----GC-CAAGC-----UCUUU
Saccharomyces mikatae CCUUCAUCA--UUA-----U-ACAAAA---U--GUCUACCAUUACCACACCCACACAUUGAUAUUAUGACUAAUUGUUUAUUAGCUAAGUUCCCAU-G-GCCAC-UUU-UUACU-UUUUU
))))))))
template boundary
610
620
630
640
650
660
670
680
690
700
710
720
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
IVb IVb IIc IVc
structures
(((((((((( (((((((((((((( )))))))))))))) ((((((((((((((((((((((((((((((((((( )))))))))))))))))))))))
Saccharomyces cerevisiae
CUCGUUUUCUUAUACCUAGUAUUUUUUCUGACACUGUUUAAGGUGACAGAAAAAA-AGGAGUUUA-AGUUAGAUUUGCAAA-CAGACGGUGCUA--AGCGCUGUCACU-UU-AUGUCUAU
Saccharomyces paradoxus CUCGUUUUCUUAUACCUAGUAUGUUUUCUGGCGCUUUUUGAAGUGACAGAAAAAA--GGAGUUUA-AAUUAGAUUUGCAAA-CGGACGGUACUA--AAUACCGUCACU-UUUACGUCUAA
Saccharomyces kudriavzevii CUCGUUUUCUUAU------UGUGUUUUCUGUCACUGUG-AAAGUGACGGAGAAAA-AGGAGUUUGGAAUCAGAUUUGCAAAACGGGCUGUAUCAAUAAUACUGUCAUUCCUAAUGUCUGA
Saccharomyces cariocanus
CUCGUUUUCUUAUACCUAGUAUUUUUUCUGACGCUUUUUGAAGUGACAGAACAAA--GGAGUUUA-AAUUAGAUUUGCAAA-CGGACGGAACUA--AAUACUGUCACU-UUUAUGUCUAA
Saccharomyces bayanus UUUUCUUCC----------AAUAUUUUCCGUCGCUUUC-CAAGUGACAGAAAAAAAAGGAGUUUG-AAUUAGGCUUGCAAAAGGGACAAUAUAUAUGAUACUGUCACUCCUAAUGUCUAA
Saccharomyces pastorianus UUUUUUUC-----------AAUGUUUUCCGUCGCUUUC-CAAGUGACAGAAAAAA-AGGAGUUUG-AAUUAGGCUUGCAAAAGGGGCAAUAUCAAUGAUACUGUCACCCUUAAUGUCUGA
Saccharomyces mikatae CUCAUUUUCUUAUUUUUAUUAUAUUUUCUGUCACUUCU-GAAGUGACGGAAAAGA--GGAGUUUG-AAUUAGAUUUGCAAAACGGGCGGUAUCAAGAAUACUGUCACUCUAUAUGUCUAA
((((((((((((((((( ))))))
CS2
730
740
750
760
770
780
790
800
810
820
830
840
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
IVa V V IV
structures
))))))))))))))) ((((((((((((((((((((((((((((((((((((((( ((((((((<<<<<<< )))))))) (((((((((((
Saccharomyces cerevisiae
CUUAUCGUUAACUCUGGAAAAAGAAAAA-GGAAAAAGAACG-UCAGGGAACA-UGAGUAUAU---AUAGAAAUGGUUUAUUCUAG--------UUUUUUCCGUUUUUUCAGUAGAUUUUU
Saccharomyces paradoxus CUUAUCGUUAACUCUGCAAAAAGAAAACAAGAAAAAGAAAA-UCAGUGAAUA-GGAGUAUAU---AUAGAAAUGGUUUAUUCUA--------UUUUUUUUUGUUUUU-CAGUAGAUUUUC
Saccharomyces kudriavzevii UUCAUCGUCAACUCUGUAAAAAGAGAACAAGAAAGGDAAAA-UUGAUGGGCA-AAAGUAUAU---AUAGAAAUGGUUUAUUCCCG--------UUUUUUCCAUUUCU-CAGUAGAUUUUU
Saccharomyces cariocanus
CUUAUCGUUAACUCUGCAAAAAGAAAAUAAGAAAAAGAAAA-UCAGUGGAUA-GGAGUAUAU---AUAGAAAUGAUUUAUUCUAG-------UUUUUUUUCGUUUUU-CAGUAGAUUUUC
Saccharomyces bayanus UUUAUCGUCAACUCUGUAA--AGGAAGCAAGAAAGAGAAAGGUUGCUGGAAAUAAAAUUUGUACAAACAAGACGGUUUAUUCUAG---------UUAUUCCAUUUUU-CAGUAGAUUUUU
Saccharomyces pastorianus UUUAUCGUCAACUCUGUAA--AGGAAACAAGAGAGAGAAAGGUUGGUGGAGAUUAAAUCUGUAGAAAGAGGAAGGUUUAUUCUAG---------UUAUUCCAUUUUU-CAGUAGAUUUUU
Saccharomyces mikatae UUUAUCGUCAACUCUGCAAAAAGAAAAUAGGAAGAAGAAAA-UAGGCGGAUA-AGAGUAUAU---AGAGAAAUGAUUUAUUCUAUUUUUUUUUUCUUUUUCGUUUUU-CAGUAGAUUUUU
))))))))))))))) (((((((( )))))))) (((((((((((
CS2 CS3 CS3 CS4
850
860
870
880
890
900
910
920 930 940 950 960
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
VI I
structures
((((( >>>>>>> )))))))))))))))))))))))) ))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))
Saccharomyces cerevisiae
GCCUUUAAA-AGAAUAAAUCCCACU----ACAAAAAGGUAAAAUAAAAAAUCUAUUCACUGAACUUAC-UGAU-GAAAUUUCCAAAUGUGCCCCGUACAUCGAACGAUGUGAC----AGA
Saccharomyces paradoxus GCCUUUAAA-AGAAUAAAUUCCAUU----AAAAAAAGG-AAAAAGAAAAAUCUAUUCACUGAACUUGC-UGAUAGAA-UUUGCAAAUGUGUCAAGUGCAUC-AAGGAGAAGAU----AGA
Saccharomyces kudriavzevii CCCUUUUGCGAGAAUAAAUUGACACUUGAACAAAAAGCUUCGAAGAAAAAUCUAUUCACUGAACUUAUAU-AUAGAAAAAU-CAAAUGUGCUAAGUAUAUUUAAAAUGGAAACAAAUAGG
Saccharomyces cariocanus
GCCUUCAAA-GGAAUAAAUUCCAUU----AAGAAAAGGUAAAAAGAAAAAUCUAUUCACUGAACUUAC-UGAUAGGA-UUUGCAAAUGUGUCAAGUGCAUC-AAGGAGAAGAU----AGA
Saccharomyces bayanus GCCUUUUACUAGAGUCAAUUUAACCA-GUA-UAAAAGGUUCAAGGAAAAAUCUAUUCACUGAACUUAU-CA--CGAAACCU-CAAAUGUGUCAGACGCAUUAAAAAGAUAAAU-------
Saccharomyces pastorianus GCCUUUUACUAGAAUUAAUUUAACCA-AUA-UAAAAGGUUCAAGGAAAAAUCUAUUCACUGAACUUAU-UA--GAAAACCU-CAAAUGUGUUGGAUGCAUUGAAAAGAUUAAC-------
Saccharomyces mikatae GCCUUUCGAGAGAAUAAAUUCCACU-----AAAAAGGGU-UAAAGAAAAAUCUAUUCACUGAACUUAU-UGAUGAAAACUU-UAAAUGCGUCAAGUACAUCAAAAGAGGAAAC----AGA
)))))))))) ))))))))
CS4 CS1
970
980
990
1000
1010
1020
1030
1040
1050
1060
1070 1080
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
|-------------------------------------------V
structures
)))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))
(((((((((((((((((((((((((((((((((((((((((((((
Saccharomyces cerevisiae
G--AAAAAUACG---AGUAGGUAAAUAAGCCAAAAGGCAAGGGUGU-CCU-------------------UUCUUAAGCAUCGGUUAGG--U-UUGCG-GGCGAUCAGUAACUG-----AA
Saccharomyces paradoxus GG-AAAAACUCG---AUAAGGCAAACAAGCCAAAAGGCAAGGAUGC-CCU-------------------UUCUCAAGCAUUG-UUAGG--AUUA-UG-GGCUACCAGUAAGCG-----AA
Saccharomyces kudriavzevii GGGAAAGAGAUA---GGUAGAUAAACAGCCCAAGGGACAAGGACAC-CCU-------------------UCCUCAGGCACUGAAUAUA--UUGG-AGA-GUGGACAGUAACAG-----AG
Saccharomyces cariocanus
GG-AAAAAC-CU---AUUAGGCAAACAAGCCAAAAGACAAGGAUAC-CCU-------------------UUCUCAAGCAUUG-UUAG---UUUA-UG-GGCUACUAGUAAGCG-----AA
Saccharomyces bayanus ---CAAAAAAAC---GGUAUGCAAGCGAGUCAAAAGACUGGUACUC-CCUUCGUUUCCUGUCCCAUUUUGCCUCAAGCAUUGAAU--AAGUUUG-CGA-GCGAAUAAUAACCG----GGG
Saccharomyces pastorianus ---CAAAAAAAAAAAGGCACGCAAGCAGGUCAAAAGACUAGGACUC-CCUUCGUUUCCUUUCCCAUUUUGCCUCAAGCAUCGAAU--AAGUUUG-CGA-GCAAAACAUAACCG----GGC
Saccharomyces mikatae GGGAAAGAACCA---GGUUGGCAAACAAGCAAAAAGGCAAGGACGAACCU-------------------UCCUCAAGCACUGAAU-GU--UUUG-CGA-GUGAAUGGUAAGCGCGAGAAA
1090
1100
1110
1120
1130
1140
1150
1160
1170
1180
1190
1200
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
IIa----------------------------||----------VIIb----------|
VIIb VIIc VIIc
structures
((((((((((((((((((((((((((((((((((((((((((((((((((((((((((
))))))))))))))))))))))))))) ((((( ))))))
Saccharomyces cerevisiae
CAAUGACACAAGAUC--AAGAACGUAAUUUGAGAUUUUUCAA-GAUGG-UUUUUUUAGGUAU--CUAUUAAAA-CUACU--UUGAUGA-UCAAUACGGUAUUUUUGU-CGCAUU------
Saccharomyces paradoxus AAAUGAUACAGGACAGAAAAAACAUAAUUCGAGAUUUUUCAG-GAUGGAUUUUUUUAGGUAU--CUAUCAAAA-CUAUU--CUGAUGA-UCAAUACAGUAUUUUUGU-CGCAUUACUAUU
Saccharomyces kudriavzevii AAAUGAUACAAGAUG-GAAAGCCAUAAAUUGAGAUUU-UCUUGAAUGGGUUCAUUUAGAUAUUUCUC-UUUAGCCAUUUU--UGAUAA-UCAAUACAGUAUUCUUGUUCCCAUCCUUGUC
Saccharomyces cariocanus
GAAUGAUACAGGAUGAAAAAAACAUAUUAUGAGAUUUUUCAG-GAUGGAUUCUUUUAGGUAU--CUAUCGAAA-CCAUU--CUGAUGA-UCAAUACAGUAUUUUUGU-CGCAUUCUUAUU
Saccharomyces bayanus AAAUGAUACAA-GAG-AAAAUCCAUAAUUUGGGAUCU-UCUUGGAUGGAUUCAUUUAUGUAUUUAU--UUG--CUCAUUU-UUGAGGA-UCAAUACAAUAUUCUUGU-CCUAUCCUUGCU
Saccharomyces pastorianus AAAUGUUACAA-GAG-AAAAUACAUGAUUUGGGAUCU-UCUUGGAUGGAUUUGUUUACAUAUUUCU--UUA--CUCAUUUUUUGAGGA-UCAAUACAAUAUUCUUGU-CCCAUCCUUGCU
Saccharomyces mikatae UGAUGAUACAAGUUG-AAAAGACAUAAUUUGAGAUUUUUCAA-AAUAGAUUAUUUUAGACAU-CCUACUUUAAUCAUUU--UUGAUGAAUCAAUACGGUAUUUUUGU-CGCUUCCUUAUU
(((((((((((((((( ))))))))) (((((((((((((
|-CS5a||--CS5b-| |--CS5b-| |----CS6----|
1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
VIId VIId VIIa
structures
(((((((( ))))))) )))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))
Saccharomyces cerevisiae
--------------------AUUUUCCAAGCGGAAGGAACCGUGUGUUCAUUUUAUGAAUCUU-GGUGUUGUAU---------UCA----------CAGCUACU----UCUCC-UAAU-G
Saccharomyces paradoxus ACGGUA-GU-GCAGACAUUAGUU-UCCAAGCGGAAGAAACUGUGUGUUCAUUUUAUGGAUUUU-CGUGUUGUA-CGAUUUUUUUCAGUUGCGUUAGCAC-UAC-G---UGCCCACAAUA-
Saccharomyces kudriavzevii AGAUUAAGGAAGGAACAUUAAUU--CCAAACAGGAAAAACUGUGUGUUCACUUCGUGGGUUUG-CGUGUUGUA-CAUUUC-CUUCAUCCGUGUUGGCGGUUACU-U----UCCUCAAU-A
Saccharomyces cariocanus
ACGGUACGU-GCARACAUUAGUU-UCCAAGCGGAAGAAACUGUGUGUUCAUUUUAUGGAUUUU-CGUGUUGUA-CGAUUUUUGUCAGUUGCCUCAACAACUAC-G---UGCCCACAAUA-
Saccharomyces bayanus AAAGUAAAGAACGGGCAUUAAUU-UCUGAACGGAAAGAAUUGUGUGUUCACUUUAUGG--UUUUCGCAUUGUA-CAUUUUUC--AACUUGCAUGAGCAGU-CGGU--UU--CCUCAAU-A
Saccharomyces pastorianus AAAGUAAAGAACGGGCAUUAAUU-UCCGAACAGAAAGAAUUGUGUGUUCACUUUAUGG--UUUUCGCAUUGUA-C-UUUUCCU--ACUUGCAUUAGCAGU-UGUU--UG--GCUCACU-A
Saccharomyces mikatae ACAGUAA-U-GCAGACAUUAACU-UCUGAGCGGAAGGAACCGUGUGUUCAGUUUAUGGAUUUU-CGUGUAAAG-CGUUUUUU--CGGUUGCGAUAGCAGUUACU-UACUUUCCUCGAU-G
))))))))))))) )))))))
|----CS6----| |-CS5a|
1330
1340
1350
1360
....|....|....|....|....|....|....|....|.
Sm site
structures
))))))))))))))) |||||||||
Saccharomyces cerevisiae
--CCU--UCGAUGCAUUUAGAUAAUUUUUGGAAA--CAUUU
Saccharomyces paradoxus --CUU--CCGAUGCAUUUAGAUAAUUUUUGGAAA--CAUUU
Saccharomyces kudriavzevii UACC--UUCAGUGCAUACA---AAUUUUUGGAA---CAAUU
Saccharomyces cariocanus
--CUU--CCGAUGCAUUCAGAUAAUUUUUGGAAA--CAUUU
Saccharomyces bayanus CUU--UUUCGGUGCUUACGAAUAAUUUUUGGAACUUCAAUU
Saccharomyces pastorianus CUUU-UUUCGAUGCUCACGAAUAAUUUUUGGAACCUCAUUU
Saccharomyces mikatae --CC--UUUGAUGCAUUCAGAUAAUUUUUGGAA---CAUUU
|||||||||
CS7