10 20 30 40 50 60 70 80 90
100 110 120
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A) MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENG-TQPVKDVCKELNNQEQNGPIDPENNRGQE
Homo sapiens (B) ----------------------------------MSQGPPTGESSEPEAKVLHT---------KRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLRELCVKLMFLHPVDYGRK
Caenorhabditis elegans -------------------------MNGDTDASSSRTGAPRKP--RPEIQIYRPGMLRQGGSTKSLSSTNEEARPPRPEKLNTTTTTMSGNSRRRSNDTDSVTSRGGSGSTTPDANVINA
Schizosaccharomyces pombe ------------------------------------------------------------------------------------------------------------------------
Saccharomyces cerevisiae --------------------------------------MDNEEVNEECMRLFFKN-------------ARAHLDKHLTSRLTCDENAYITFRCFLDGIHRKSTRFLEELLLKQENMYHNN
130 140 150
160 170 180
190 200 210
220 230 240
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A) SFPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPG
Homo sapiens (B) AEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAG-----------IGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKE-----------------MDWAQM
Caenorhabditis elegans MNERGGGRNRFEKGYRQQQRTDGPSNYNSTQSLYDTRQHGG----------YMEYQGNHRSNHRNNGRYSNQQHQQHRQPFER-PGGNHYTRGFNERASMRGDG---------AIARRPQ
Schizosaccharomyces pombe ------------------------------------------------------------------------------------------------------------------------
Saccharomyces cerevisiae NYERINDSVIPLVLKLLWLQIHEPTLQWFEHWFHDIMRLSN-----------RRKFRVFRIFQKKMIQFFKITHRYYYDIIEHLCAKYDMN-----------------------------
250 260
270 280 290
300 310 320
330 340 350
360
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A) SAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKTSAKEYRGTLRVTFDAEAM
Homo sapiens (B) ACHRCLVYLGDLSRYQNELAG---VDT--------ELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYN---------------------------------VEAMYCYLRCIQSEVSF
Caenorhabditis elegans GSRRQRNDSINSYNPRVLYQRTRGAN---------DENHPKRRDAAVEKKPKEPRRYRGEHDDRDDD------------------------------------ASEYHGTLENHMSSGRL
Schizosaccharomyces pombe --------------------------------------------------------------------------------------------------------------MSQQLSSNEI
Saccharomyces cerevisiae --------------------------------------------------------------------------------------------------------SVISNALFAKLNLMQY
370 380 390
400 410 420
430 440 450
460 470 480
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A) NKESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDT
Homo sapiens (B) EGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVN---------------------------------------------------------------------------
Caenorhabditis elegans AGRIQIVQRSQNGTEAGGNRNRQSSEEKPRTYQKRSQNQSEMANR---------------------------------------------------------------------------
Schizosaccharomyces pombe CEEQGKLVKALCEAAQGGFKHDLYEKIIAIEIEVEKKLLN--------------------------------------------------------------------------------
Saccharomyces cerevisiae TDGLSTHEKIILNTSNPLTFSIVISLQRCVINLGSTHFYKTLLNK---------------------------------------------------------------------------
490 500 510
520 530 540
550 560 570
580 590 600
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A) DDEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLL
Homo sapiens (B) ----------------------------------------------------------------------------------FMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLP
Caenorhabditis elegans --------------------------------------------------------------------------------------AEINRRRQEDIDRNEGKQIREISEKIEKLSAPVK
Schizosaccharomyces pombe --------------------------------------------------------------------------------------------RLKSIQTNTFERPDIIWSCCHYKIIQHF
Saccharomyces cerevisiae ----------------------------------------------------------------------------------------------PSNKPKSVEGFEKSIRYLNIASLYLP
610 620 630
640 650 660
670 680 690
700 710 720
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A) SRDRISPEGLEKMAQLR----AELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDG---------
Homo sapiens (B) SSPNLSLASEDEEEYESGYAFLPDLLIFQMVIICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIR----LQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDP---------
Caenorhabditis elegans KRD---LKSAEKMAEIS----MELANIYSQVIIHDVIYSFTAGLEQKLFRQAFYKCIESLRTGS-NSAAPDARLIRAVTQKLLLNGIVYYENLIATYETQFHVALTDALTWQSGSPSDEE
Schizosaccharomyces pombe RSRFREIHPRHVVEKKK----------------TKKVFFKFLKTCAIFYQTCISELISKF---------------------QLDSYRPFFCKWTSSATVSSTISNDE-------------
Saccharomyces cerevisiae AVGDTYFQRAKIYLITG-----------------KFSLYFFELVRGALVRIPSKCALNNLKDFILTPDFP-------ERRRLMKKLAILVSKDLKGEKSFFEGQIVLQFLS---------
730 740
750 760 770
780 790 800
810 820 830
840
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A) -------LAIRSKPLR-KTVKYALISAQRCMICQGDIARYREQASDTA-NYGKARSWYLKAQHIAPKNGRPYNQLALLAVY----------------------TRRKLDAVYYYMRSLAA
Homo sapiens (B) -------EPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSE-GFESDSSHDSARASEGSDSGS---------------------------------DKSLEGGGTAFDAETDS
Caenorhabditis elegans LCEQYIELPIGIQKFDSATQKTAIKSLSRHLISLGDLHRYKSLIDGSE-NYEISKSCYQKSSQLWPSTGHPYNQLGIVVYYSMLYRSARRARLVPVDVLSRQRQKRVIDEFFCLTRALAC
Schizosaccharomyces pombe -------MSSIPEASYSRNHMEALECVYNCFIYLGDMARYSSTCLKKRGAYDRALGFYDLAHRTLPGNGMHRNQIAVVWAS----------------------DECIVESIYWFSSALCS
Saccharomyces cerevisiae ------IVEHTLVPQSWNASRASNCWLLKEHLQMAALKYHSGNINVILENLAATMGSFDLMFTTRK-------------------------------------SKEQKNKLKYADLSERQ
850 860 870
880 890 900
910 920 930
940 950 960
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A) SNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAV
Homo sapiens (B) EMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPS----EASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSE
Caenorhabditis elegans SHPYEVAKDRLKQRIDAMRTKVAKYQPVLDKESGIVKEQGNVLRR--------LQRIRQIWIHPITETSQDGTGERIVDDVLVHFMEHSKAKLHRRAVSYLCDTFGMLVTKIGMDHFESV
Schizosaccharomyces pombe EDPPKSALLNLLKQLIAFYRRCFAVHFEFVSPMMILLFIIS-----------------DCCIHSLKEIQPFKCPSIMVKDLEN----------------------SLLQSNIRNVGYEKK
Saccharomyces cerevisiae VFFLDLSFDFIANIIDVVIKPSWQKNMEDFRYLAIIRLLMCWIKS-----------YRSILQYTHRHRKFCTSFALLLNDLIN----------------------SPLNCSGNIYSHRPK
970 980 990
1000 1010 1020
1030 1040 1050
1060 1070 1080
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A) AEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLKELLPSVKVWSDWMLG
Homo sapiens (B) SSGRSCRNERSIQEKLQVLMAEGLLPAVKVFLDWLRTN--------PDLIIVCAQSSQSLWNRLSVLLN--------------------------LLPAAGELQESGLALCPEVQDLLEG
Caenorhabditis elegans SERAFGLLYASLSKSETDFSADQLVKFSAMFIYAAQVN-----FDKSTPSTSKSQLHTAVRTIFTYFL--------------------------VLLEHISTHTTLLLPAANVIATWILH
Schizosaccharomyces pombe NLYYISSAFSNLLHCRYFNCNDRLRSFYYRFSSWLFHQ-----------TLACAKEVESERAPTSYLTS--------------------------CLPSIKVILARVLESSPAFG-----
Saccharomyces cerevisiae RSYLFREDIIFREFSCINFALTDFNDDYVYDSPDMINN-----------IIGCPTLTKVLSPKEECVLR---------------------------IRSIIFSGMKFLEKNDTGVIWN--
1090 1100
1110 1120 1130
1140 1150 1160
1170 1180 1190
1200
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A) YPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTAVNQSEVPLYKDPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVS
Homo sapiens (B) CELP--DLPSSLLLPEDMALRNLPPLRAAHRRFN--FDTDRPLLSTLEESVVRICCIRS--FGHFIARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFR-----------------
Caenorhabditis elegans ADT--EELLSYLEHLEPLSSTIISSFSNFP-----------PNLESEAENPENVTTPEAILLASFFKIYEPNPTPVRCSRSTN--ISQAVEKLKILGFSAE-------------------
Schizosaccharomyces pombe ----------------------------------------------------------------FIERNELEQLSYHFRICEKFFKESSENK----------------------------
Saccharomyces cerevisiae -----------------------------------------------------------------ASKYKFDLISPNIKIKRQIALSEISSKIN--------------------------
1210 1220 1230
1240 1250 1260
1270 1280 1290
1300 1310 1320
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A) VAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVV
Homo sapiens (B) ----------------------------------MAQEEARRNR---------------LMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVII
Caenorhabditis elegans ----------------------------------KSEKSGENGK--------------QKLGDGLEEPKSREQMIDEQRGLGKTTIVIHPEYLIPDTN----------------------
Schizosaccharomyces pombe ------------------------------------------------------------MLNLFEDYNEFGLCKSFICLFKRLNEDIIGPKLNINPPD---------------------
Saccharomyces cerevisiae -----------------------------------------------------------VKTQQERVVSSRKVEAKRDEQQRKRAGKIAVTELEKQFAN---------------------
1330 1340 1350
1360 1370 1380
1390 1400 1410
1420 1430 1440
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A) PLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITG-QLGNNDDLILSCCLHYCKDKAKDFMPASKEEPIRLLREVVLLTDDRN
Homo sapiens (B) PRTVIDGLD-LLKKEHPGARDG-------------IRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQGAGEEDPSGMVTIITGLPLDNPSVLSGPMQA
Caenorhabditis elegans --VLIGDLQ-LMKNLQAKQKTG--------------------------HLYTLTTTGKRLPTLSIVSEDLEGHEMTTNDDMILNSALRWSESLPGSTAPSAT----EISQKCVLITGDRG
Schizosaccharomyces pombe -----------------------------------------------------------YTTHPFSESIKRFYQISKILNLLLS------------------------------------
Saccharomyces cerevisiae -------------------------------------------------------VRRTKKLSPLPEKDGVSSELVKHAASRGRKTITG-------------------PLSSDFLSYPDE
1450 1460
....|....|....|....|....|.
Homo sapiens (A) LRVKALTRNVPVRDIPAFLTWAQVG-
Homo sapiens (B) ALQAAAHASVDIKNVLDFYKQWKEIG
Caenorhabditis elegans LTIKAIGNNFPCRGISNFTKWIINV-
Schizosaccharomyces pombe --------------------------
Saccharomyces cerevisiae AIDADEDITVQVPDTPT---------