Currently there are 56 species, 33 vertebrates, 1 fungus, and 22 ciliates, for which the secondary structures of the RNA component of telomerase (TR) have been determined. These structures were constructed from the alignment of TR sequences and secondary structure prediction. Presented within the secondary structure is the primary sequence, baseparing confirmed by covariation, labeled template and pseudoknot, conserved regions, and the various domains. Where applicable, a reference citation to the original article that is linked to the online journal. The structures are organized by taxonomy. The view button will open a separate browser window with a .jpg of the secondary structure requested. Renderings of the secondary structures are available for download in high quality .pdf as well as .jpg formats.
The following table is a listing of various tertiary structure fragments from the telomerase ribonucleoprotein. The tertiary RNA structures were derived from NMR spectroscopy while the tertiary protein structures were derived from X-ray crystallography and NMR spectroscopy. Below is a brief discription of the protein or fragment, the protein data bank (PDB) ID number linked to Research Collaboratory for Structural Bioinformatics (RCSB) record, and the reference to the original article linked to the online journal. The structures are organized by component and taxonomy. The tertiary structures can be viewed online within the browser, or can be downloaded from the .pdb link and viewed by a separate molecular visualization program. A standard nomenclature is used throughout the online database for consistency and clarity. Homologous proteins are given a single name for simplicity.
The view button will open a separate browser window for the .pdb of the tertiary structure requested. To view the structures within the browser, java is required and is available from Sun Microsystems. The tertiary structures presented within the separate browser window can be set to various renderings. The proteins and nucleic acids are depicted by specific colors. The tertiary structures are available for download in .pdb file format. A molecular visualization program, such as PyMol, RasMol, or Swiss-PdbViwer, is necessary for rendering. The direct links for the download pages are available for Pymol, RasMol, and Swiss-PdbViewer. The image on the home page to the database was constructed from the .pdb files listed and rendered in Pymol.