The intrinsic telomerase RNA (TR) component contains the template for nucleotide synthesis. TR contains a universal pseudoknot and a ubiquitous stem-loop junction structure [helix IV in ciliates, CR4/5 in vertebrates, three-way-junction (TWJ) in yeasts, and P6/P6.1 in filamentous fungi]. In addition to telomerase reverse transcriptase (TERT) binding sites, TR has species-specific protein binding moieties required for biogenesis. The most striking characteristic of TR is the astounding divergence in sequence, structure, and size, ranging from 100 nucleotides in ciliates, 400-500 nucleotides in vertebrates, and 1000-2000 nucleotides in fungi.
Below are details on the RNA component sequences, the scientific and common name where applicable, the length, the GC content, the nucleotide sequence (.seq button), the genbank accession numbers that are linked to the record at the National Center for Biotechnology Information (NCBI), and the original literature citations that are linked to the published online journal. The sequences are organized by general taxonomy. The GC% content is not provided for putative/partial sequences. The GC% content has been adjusted, where necessary, to account for any adjustment to the 5' or 3' ends compared to the NCBI record, numbers in parentheses.