10
20 30
40 50
60 70
80 90 100 110 120
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens
MSFRGGGRGGFNRGGGGGGFNRGG~SSNHFRGGGGGGGG~~~~~~~~~~GNFRGGGRGGFGRGGGRGGFNKGQDQGPPERVVLLGEFLHPCEDDIVCKCTTDENKVPYFNAPVYLENKEQ
Mus musculus
MSFRGGGRGGFNRGGGGGGFNRGGGSNNHFRGGGGGGGGSFRGGGGGGGGSFRGGGRGGFGRGGGRGGFNKFQDQGPPERVVLLGEFMHPCEDDIVCKCTTEENKVPYFNAPVYLENKEQ
Schizosaccharomyces pombe MS~~~~~~~~~~~~~~~~~~~~~~~~~~~FRGG~RG~~~~~~~~~~~~~~~~~GGFRGGRGG~~~~~~SRPFTPSGPPDQVIELGLFMHDCEGEMVCQ~STNVK~IPYFNAPIYLENKSQ
Saccharomyces cerevisiae MS~~~~~~~~~~~~~~~~~~~~~~~~~~~FRGGNRGG~~~~~~~~~~~~~~~RGGFRGGFRG~GRTGSARSFQ~QGPPDTVLEMGAFLHPCEGDIVCR~SINTK~IPYFNAPIYLENKTQ
Candida glabrata MS~~~~~~~~~~~~~~~~~~~~~~~~~~~FRGGFRGG~~~~~~~~~~~~~~~RGGSRGGFGGRGGARGGRPIQ~QGPPDTVLEMGEFMHPCEGDVVCR~SINTK~VPYFNAPIYLENKTQ
Ashbya gossypii MS~~~~~~~~~~~~~~~~~~~~~~~~~~~FRGNSRGG~~~~~~~~~~~~~~~RGGARGGSRGGRGGFGGRQFQ~QGPPDSVVEMGAFMHDCEGDIVCR~SINTK~IPYFNAMIYLENKTE
Tetrahymena thermophila
M~AK~DFKSAANNAG~~~~~~~~~~PRKDFRQGGGNAGG~~~~~~~~~~~~~~~~~RGGFNKGGNFRGNNN~RDMGPPERVEPVCVFSHTCGDQIVVKAT~DVKKVPKFNRGIYLENKTK
Cryptosporidium parvum MS~~~~~~~~~~~~~~~~~~~~~~~~~~~ARG~SRG~~~~~~~~~~~~~~NFRGG~RGSSRGKGGVPSNGRPSFSGPPSSITELGEVLHSSEHELVCKSFLNDQ~VPYFNGRIFLENKEE
Trypanosoma cruzi MT~~~~~~~~~~RGGGGG~~~~~~~~~~~FGRGGGGGRG~~~~~~~~~~~~~FGGPRGGRGG~~GGRGGREAE~PDPPESLELIGTFMNAAEGYLVYKVTIPEV~VPRFNAFVYTENRAK
130
140
150
160
170
180
190
200
210
220
230
240
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens
IGKVDEIFGQLRDFYFSVKLSENMKASSFKKLQKFYIDPYKLLPLQRFLPRPPGEKGPPRGGG~~~~~~RGGRGGGRGG~~GG~~~~~~RGGGRG~~~~~~~~~GGFRGGRGGGGGGF~R
Mus musculus
VGKVDEIFGQLRDFYFSVKLSENMKASSFKKLQKFYIDPYKLLPLQRFLPRPPGEKGPPRGGGG~~~GGRGGRGGGRGG~~GG~~~~~~RGGGRG~~~~~~~~~GGFRGGRGGGGG~F~R
Schizosaccharomyces pombe IGKIDEVFGPMNQVYFTVKPSEGIVSSSFKVGDKVYLSGDKLIPLDRFLPKPKTVGPKKP~~~~KGARNGPAGRGGRGGFR~~~~~~GGRGGSRGGFG~~GNSRGGFG~~GGSRGGFG~~
Saccharomyces cerevisiae VGKVDEILGPLNEVFFTIKCGDGVQATSFKEGDKFYIAADKLLPIERFLPKPKVVGPPKP~~~~KNKKKRSGAPGGRGGAS~~~~~~MGRGGSRGGF~~RGG~RGGSSFRGG~RGGSSFR
Candida glabrata VGKVDEILGPLNEVYFTIKCGEGVQATSFKEGDKFYIAPDKLLPIERFIPKPKVAGPPKP~~~~KNKKKRSGAPAGRGGARGG~~~FGGRGGSRGGFGGRGGSRGGFGGRGGSRGGFGGR
Ashbya gossypii VGKVDEILGPLNEVFFTIKCAEGVKASSFKDGDKFYISPEKLLPIERFIPKPKVAGPPKP~~~~KRKRAAGGAP~GRGGFG~~~~~~~GRGGSRGGFGGRGGARGGFGGRGGARGGFGGF
Tetrahymena thermophila
VGTVDEILGPIDGFYYSIKLVEGVSADSYKPGDKFYMGWDDTLPIDRFLPKPKGAGGPRR~~~GPGGIQKGGPGG~RGGFQ~~~~~~~~KGGFNNNNN~~~~~KGGFNKGGFNKGGFN~K
Cryptosporidium parvum IGKVDEILGPINTYFFSIKMNNGVKAESFVTGTKIFIDPQQLLPMSRFLPKPSTQKTTKK~~~~~~~~TGEAAIGKKRGFN~~~~~~~~GSPGRGGQS~RG~VRGRGFARGASPRGFRGR
Trypanosoma cruzi IGKIDEVMGNTTDVMFSVMPMPGVQAGSISEGDNIFVSPTQLTPVRVFTDPPKPRGRGGRGGGGRGGRSANGGGSSRGNFGGGGRGNFGGGSSRGNFG~~GGGRGNFGG~GSSRGSFGGG
250
260
270
280
....|....|....|....|....|....|....|....|..
Homo sapiens
GG~RGGG~FRGRGH~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Mus musculus
GG~RGGGGFRGRGH~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Schizosaccharomyces pombe GGSRGG~~SRGGFRG~~GSRG~~~~GFRGRF~~~~~~~~~~~
Saccharomyces cerevisiae GGSRG~~~~~GSFRG~~GSRG~~~~GSRGGF~~RGGRR~~~~
Candida glabrata GGSRGGFGGRGGSRGGFGGRG~~~~GSRGGFGGRGGRS~~~~
Ashbya gossypii GG~RGG~~SRGGFGGRGGARG~~~~GSRGG~~~RGGKRF~~~
Tetrahymena thermophila
GG~NAGG~FKKNFKN~~~~~~~~~~~~~~~~~~~~~~~~~~~
Cryptosporidium parvum GTSS~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Trypanosoma cruzi GRGNFGGGGRGNFGG~~GGRGNYGGGGRGNYGGGGRGNGRGY