10 20 30 40 50 60 70 80 90 100 110 120

....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|

Homo sapiens -----------------MTKIKADPDGPEAQAEACSGERTYQELLVNQNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVMCEDRNL

Pongo pygmaeus -----------------MTKIKADPDGPEAQAEACSGERTYQELLVNQNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVMCEDRNL

Mus musculus -----------------MTKVKAAPEESEAQAEGCSEERTYKELLVNLNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVLCEDQNL

Bos taurus -----------------MTKIKADPDGPEAQADACCGERTYHELLVNLNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFINKGEKGIMVLAGDTLPIEVYCHLPVMCEDRNL

Xenopus tropicalis -----------------MTKAKKEESE----EVPETPSKSYDELLAYLNPIAKPLAGRKLTKKLYKCVKKAIKQKNIRRGVKEVQKFINKGEKGIVVMAGDTLPIEVYCHIPVMCEDRGI

Danio rerio -----------------MTKVKKEKAG---EEETGGTEKSYQELIANINPIANPLASRKLSKKLYKCVKKAAKVKQIRRGVKEVQKFINKGETGIVVFAGDTLPIDVYCHLPIMCEDRSL

Saccharomyces cerevisiae MVNGSLGSRETETSAVKMGKDNKEHKESK----ESKTVDNYEARMPAVLPFAKPLASKKLNKKVLKTVKKASKAKNVKRGVKEVVKALRKGEKGLVVIAGDISPADVISHIPVLCEDHSV

Schizosaccharomyces pombe -----------------MAKDKKDHKHS------GSTEDEYDSYLPALMPIAKPLAPKKLNKKMMKTVKKASKQKHILRGVKEVVKAVRKGEKGLVILPGDISPMDVISHIPVLCEDNNV

130 140 150 160 170 180

....|....|....|....|....|....|....|....|....|....|....|....|.

Homo sapiens PYVYIPSKTDLGAAAGSKRPTCVIMVKP-----------HEEYQEAYDECLEEVQSLPLPL

Pongo pygmaeus PYVYIPSKTDLGAAAGSKRPTCVIMVKP-----------HDEYQEAYDECLEEVQSLPLPL

Mus musculus PYVYIPSKTDLGAATGSKRPTCVIMVKP-----------HEEYQETYDKCLEEVQALPTPL

Bos taurus PYVYIPSKTDLGAAAGSKRPTCVIMVKP-----------HEEYQEAYDECLEEVQALPPPM

Xenopus tropicalis PYSYVPSKSDLGAAAGSKRPTCVILIKP-----------HEDYQEAYDECLEDVQALPLPY

Danio rerio PYAYVPSKVDLGSSAGSKRPTCVIMIKP-----------HDEYKEAYDECVEEVTSLPKPI

Saccharomyces cerevisiae PYIFIPSKQDLGAAGATKRPTSVVFIVPGSNKKKDGKNKEEEYKESFNEVVKEVQAL----

Schizosaccharomyces pombe PYLYTVSKELLGEASNTKRPTSCVMIVPGG-KKKD-MSKVEEYKESYEEIIKEVPALEV--