10 20
30 40
50 60 70
80 90 100 110 120
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
|------------------------------------------
Homo sapiens -----------------MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWR---LVQRGDPAAFRALVAQCLVCVPWDARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFG
Mesocricetus auratus
-----------------MPRAPRCRAVRALLRSQYRQVWPLATFVRRLGPEGRQ---LVQPGDPKVFRTLVARCLVCVPWDSQPPPADLSFHQVSSLKELVARVVQRLCERGERNVLTFG
Mus musculus -----------------MTRAPRCPAVRSLLRSRYREVWPLATFVRRLGPEGRR---LVQPGDPKIYRTLVAQCLVCMHWGSQPPPADLSFHQVSSLKELVARVVQRLCERNERNVLAFG
Rattus norvegicus
-----------------MPRAPRCPAVRSLLRSRYREVWPLATFVRRLGLEGSR---LVQPGDPKVFRTLVAQCLVCVPWGSQPPPADLSFHQVSSLKELVSRVVQKLCERGERNVLAFG
Canis familiaris -----------------MPRAPRCRAVRALLRGRYREVLPLATFLRRLGPPGRL---LVRRGDPAAFRALVAQCLVCVPWGARPPPAAPCFRQVSCLKELVARVVQRLCERGARNVLAFG
Bos taurus -----------------MPRAPRCRAVRALLRASYRQVLPLAAFVRRLRPQGHR---LVRRGDPAAFRALVAQCLVCVPWDAQPPPAAPSFRQVSCLKELVARVVQRLCERGARNVLAFG
Coturnix japonica
MERGADPGVGVRRRLHNMARAEPFAAVLGALRGCYAEATPLEAFVRRLQDGGTGEVEVLRGDDAQCYRTFVSQCVVCVPRGARPIPRPICFQQLSSQNEVITRIIQRLCEKKKKNILAYG
Gallus gallus MERGAQPGVGVRR-LRNVAREEPFAAVLGALRGCYAEXTPLEAFVRRLQEGGTGEVEVLRGDDAQCYRTFVSQCVVCVPRGARAIPRPICFQQLSSQSEVITRIVQRLCEKKKKNILAYG
Xenopus laevis -----------------MPLRTGGATLLSILQRLYGQVLGIVEYTDTLQVPGGIKVPVLLEGDSEKFRSFVAELVVCIPRGTKPLPSPVSFLQLSTQREVVARVIQRICEKKRKNVLAFG
Oryzias latipes ------------------MTSGDLSSVLNILRSLYKRTRTLEEFADGVVFREGRRAALLQPSDTHSFKSFVRGVFVCSDEELQDVPSC---NQTCTFPELLAFILNSLKRKRRRNVLAHG
Oryzias melastigma
------------------MTSEDVSRVLELLRSLYKRTQTLQEFADGVVFRDGRRATLLQPSDSIVFQTFVRAVFVCSDEELREVRSS---KQICTFSEILAFVLNNLKRSKSNNVLAQG
Epinephelus coioides
------------------MSTADLSPTLDILRSVYQHVQTLEQFTDSIVFREGHRAQLTEHTDTNRFKSFVRGVFVCFDRELQQVPSC---NRICTLPELLAFVLNSLKRKRKRNILAHG
Takifugu rubripes
------------------MSITDLSPTLGILRSLYPHVQVLVDFADDIVFREGHKATLIEESDTSHFKSFVRGIFVCFHKELQQVPSC---NQICTLPELLAFVLNSVKRKRKRNVLAHG
Danio rerio -------------MSGQYSTDGGFRPVLEILRSLYPVVQTLEEFTDGLQFPDGRKPVLLEETDGARFKKLLSGLIVCAYT-PPQLRVP---AQLSTLPEVLAFTLNHIKRKKLRNVLGFG
region
|-----------------------------------------region
v-Ia----------------------------------|
|-----------------------------------------------------------------------RI
|-------------------------DAT
d
130
140
150
160
170
180
190
200
210
220
230
240
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
-motif
GQ------------------------------------------------------------------------------------|
Homo sapiens FALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPR--------------RRLGCERAWNHS
Mesocricetus auratus
FALLNGAQGGPPMTFTTSVRSYLPNSVTESLRVSGAWMLLLNRVGDDLLVYLLARCALYLLVPPSCAYQVCGSPLYQICATAETWPSVSRIYRPTRPVG-----RNFTHLGSTHRVRNSS
Mus musculus FELLNEARGGPPMAFTSSVRSYLPNTVIETLRVSGAWMLLLSRVGDDLLVYLLAHCALYLLVPPSCAYQVCGSPLYQICATTDIWPSVSASYRPTRPVG-----RNFTNLRFLQQIKSSS
Rattus norvegicus
FALLNGARGGPPMAFTTSVHSYLPNSVTESLCVSGAWMLLLSRVGDDLLVYLLSHCALYLLVPPSCAYQVCGSPLYQICATTDTWSSVPAGYRPTRPVG-----GNFTNLGSAHQIKNSG
Canis familiaris FALLDGARGGPPVAFTTSVRSYLPNTVTETLRGSGAWGLLLRRVGDDVLTHLLARCALYLLVAPSCAYQVCGPPLYDLCAPASLPLPAPGLPGLPGLPG--------------LGAGAGA
Bos taurus FTLLAGARGGPPVAFTTSVRSYLPNTVTDTLRGSGAWGLLLHRVGDDVLTHLLSRCALYLLVPPTCAYQVCGPPLYDLRAAAAAARRPTRQVGGTRAGF----------GLPRPASSNGG
Coturnix japonica
YSLLDENSCHFRVLPSSCIYSYLSNTVTETIRISGLWEILLSRIGDDVMMYLLEHCALFMLVPPSNCYQVCGQPVYELISRNIGPSPGFVRRRYSRFKHNSLLDYVRKRLVFHRHYLSKS
Gallus gallus YSLLDENSCHFRVLPSSCIYSYLSNTVTETIRISGLWEILLSRIGDDVMMYLLEHCALFMLVPPSNCYQVCGQPIYELISRNVGPSPGFVRRRYSRFKHNSLLDYVRKRLVFHRHYLSKS
Xenopus laevis YGLVDE-KNSLNIRLTPNICNYFPNPTTTTISTSILWETLLTRVGDDVMMYWLEQCSIFVFVPPRCCYQITGQPIYTLPSDDVFLFQSQSFTQSNVLLRYIKRNVFHLRKKYLKPKHSMT
Oryzias latipes YNFLGVAQEDRDADHFRFQGD-LSQSAAY-IHSSDLWKKVTARLGTDVTRYLLGSCSVFVLAPPSCIFQICGVPAYDRVSMTTASSGFLLRPPSRKHKSFQVGKKRRSANLTKRGSVGDV
Oryzias melastigma
YNWKT-AQENKDVNLFRFQGD-LSQSANY-IHSSEQWKKVMAHLGPDFLLHLLGSFSVFVVAPPSCVFQICGAPAYDRVSVTTASSRFLLKHPSRRHTSSRLGKNRCSVKFKMRDSAEDE
Epinephelus coioides
YSFLSLAQEERDADHFKSQGD-ITQSAAY-IHGSDLWKKVTIRLGTDITRYLLESCSVFVAVPPSCVFQVCGAPVYDRVSMTTAPAGFCLQSRARTLNGGQAGRNRGAVTVRRKHKVEND
Takifugu rubripes
YNFQSLAQEERDADQFKLQGD-VTQSAAY-VHGSDLWRKVSMRLGTDITRYLFESCSVFVAVPPSCLFQVCGIPIYDCFSLATASLGFSLQSRG--CRERCLGVNSMKRRAFNVKRYLRK
Danio rerio YQCSDVTTS---SDPFRFHGD-VSQTAAS-ISTSEVWKRINQRLGTEVTRYLLQDCAVFTTVPPSCVLQVCGEPVYDLLMPRSWSGFFLSNSDNERISGAMRKFPAVQKTVAISKKRTRD
region
|-------------region
v-Ib----------------|
D1--------------------------------------------------------|
omain-------------------|
|--------------motif T2------------------|
250
260
270
280
290
300
310
320
330
340
350
360
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
Homo sapiens VREAGVPLGLPAPGARRRGGSASRSLPLPKRPR---------------------------------------------------------------------------------------
Mesocricetus auratus
HQEAWKPPPLPSREAKRSLSITNRSVPPSKKAR---------------------------------------------------------------------------------------
Mus musculus RQEAPKPLALPSRGTKRHLSLTSTSVPSAKKAR---------------------------------------------------------------------------------------
Rattus norvegicus
HQEAPKPQALPSRGTKRLLSLTSTNVPSAKKAR---------------------------------------------------------------------------------------
Canis familiaris SADLRPTRQAQNSGARRRRGSPGSGVPLAKRPR---------------------------------------------------------------------------------------
Bos taurus HGEAEGLLEARAQGARRRRSSARGRLPPAKRPR---------------------------------------------------------------------------------------
Coturnix japonica
QWWKCKPRHQGHVSSRRKRSQ-RIQSLRPGYQSSEKVDFQAGRHISIVNAHMEKQSCSSLCLPNRAPSLKRKRDGEQVEIAAKRVKVMEKEIEKQACSIIPDVNQSSSQRH-RTWHVAPR
Gallus gallus QWWKCRPRRRGRVSSRRKRRSHRIQSLRSGYQPSAKVNFQAGRQISTVTARLEKQSCSSLCLPARAPSLKRKRDGEQVEITAKRVKIMEKEIEEQACSIVPDVNQSSSQRHGTSWHVAPR
Xenopus laevis SRMLTWRRNKSPSGLLIRSKTSMAVTTEIHSKRKLCSKDICVIPDKKRRDNLDKDDTVDHFDLPMCRSVSYL------------------------------------------------
Oryzias latipes EESRKRRRVESGVSARKRKREPEEEESRERRRG---------------------------------------------------------------------------------------
Oryzias melastigma
EKRRKKRRVESTNSSRKRKREPEEEESSKRRCD---------------------------------------------------------------------------------------
Epinephelus coioides
KRNRRVKKRQRQ--ADEKDEEEVMTCPGKRRRVG--------------------------------------------------------------------------------------
Takifugu rubripes
RKTETDQKDE------------ARVCSGKRRRV---------------------------------------------------------------------------------------
Danio rerio NEKYISVKRRRVKETVNNNNGNYRSLCFAISKKRAIDNEENISLKRRR------------------------------------------------------------------------
region
370 380 390 400 410 420 430 440 450 460 470 480
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
Homo sapiens ----------------------------RGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHF
Mesocricetus auratus
------------------------------CDLAPRLEKGPYRQAVPTPSDKTWVPNPAKSHAVPISRTTKEDLSSGVKAPGLSRSGSVCYKHKPSSTSLQSPLCQNAFQLRPYTETKRF
Mus musculus ---------------------------------CYPVPRVEEGPHRQVLPTPSGKSWVPSPARSPEVPTAEKDLSSKGKVSDLSLSGSVCCKHKPSSTSLLSPPRQNAFQLRPFIETRHF
Rattus norvegicus
---------------------------------FEPALRVDKGPHRQVVPTPSGKTWAPSPAASPKVPPAAKNLSLKGKASDPSLSGSVCCKHKPSSSSLLSSPPQDAEKLRPFTETRHF
Canis familiaris --------------------------------------------RSVASEPERGAHRSFPRAQQPPVSEAPAVTPAVAASPAASWEGGPPGTRPTTPAWHPYPGPQGVPHDPAHPETKRF
Bos taurus --------------------------------------------RGLEPGRDLEGQVARSPPRVVTPTRDAAEAKSRKGDVPGPCRLFPGGERGVGSASWRLSPSEGEPGAGACAETKRF
Coturnix japonica
AVGLIKERYISERSNSEMSGPSVVHRSHPGKRPVADKSSFPQGVQGNKRVKTGAEKRVESNRRGTEMCINPTHKPNRRGVERRINPSHKPGLNSVQTEPMEGASSGDRKQENPPAHLAKQ
Gallus gallus AVGLIKEHYISERSNSEMSGPSVVHRSHPGKRPVADKSSFPQGVQGNKRIKTGAEKRAESNRRGIEMYINPIHKPNRRGIERRINPTHKPELNSVQTEPMEGASSGDRKQENPPAHLAKQ
Xenopus laevis ------------------------------------SNMYPKTNVQVTGLITSGYKKTKTFQCQKPVSCEQKKTTAFYSVAGDCNLSLKDNVNKLITNASVPTAQSRLSFSNIFIDFGRT
Oryzias latipes ---------------------------------------------------VHHEERRQHEAVLDESTLSGKSGENDAAAVKPPPETSAAPPPLEGGPSWRSGAFPPLPSSQCFIRTLGF
Oryzias melastigma
----------------------------------------------------THHEESSQHACSEAVLVESTVSENDKSSLKMPPETSAASLPLEGEPSWRSGTFPPLPSSQCFIRTMGL
Epinephelus coioides
------------------------------------------QHEHTQEVQVCSESVGEGQPTSVEPSLTLKTLENGATVSKQPAETQTTTLPLEGGPSWRSGMFPPLPPSQCFIRTLGF
Takifugu rubripes
-----------------------------------------------------MEEDKVSCETMQDGESGKTTLVQKQPGSKKRSEMEATLLPLEGGPSWRSGTFPPLPPSQSFMRTLGF
Danio rerio ----------------------------------------MEETDQVAKIRNENHESQSFAISKKRARDNEENISLKRQRMEEIDQVAKIRNENHGSQSWKPADQRPPRPSQCSIRVLSM
region
490
500
510
520
530
540
550
560
570
580
590
600
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
|-motif
VSR-|
|--------motif CP-----------|
Homo sapiens LYS--SGDKEQLRPSFLLSS---------------LRPSLTGARRLVETIFLGSRPWMPGTPRRLP-------RLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVTPAAGVCA
Mesocricetus auratus
LYS-REGGRERLNPSFLLNN---------------LQPSLTGARRLVEILFLGMRPRTSGPLCGRR-------RLSKRYWQMRPLFQQLLVNHARCPYVRLLRSHCRFRTAAHQVAGA--
Mus musculus LYS-RGDGQERLNPSFLLSN---------------LQPNLTGARRLVEIIFLGSRPRTSGPLCRTH-------RLSRRYWQMRPLFQQLLVNHAECQYVRLLRSHCRFRTANQQVTDA--
Rattus norvegicus
LYS-RGGGQEELNPSFLLNS---------------LPPSLTGARRLVEIIFLGSRPRTSGPFCRTR-------RLPRRYWQMRPLFQQLLMNHAKCQYVRFLRSHCRFRTANQRVPDA--
Canis familiaris LYC--SGGRERLRPSFLLSA---------------LPPTLSGARKLVETIFLGSAPQKPGAARRMR-------RLPARYWRMRPLFQELLGNHARCPYRALLRTHCPLRAMAAKEGSGNQ
Bos taurus LYC--SGGGEQLRRSFLLCS---------------LPPSLAGARTLVETIFLDSKPGPPGAPRRPR-------RLPARYWQMRPLFRKLLGNHARSPYGALLRAHCPLPASAPRAGPDHQ
Coturnix japonica
LPNRFLRSAVYFEKKFLLYSRNYQEYFPKSFILSRLQDCQAGGRRLIETIFLSQNPVKEKQNQSLPQQKWRK-KLPKRYWQMRELFQKLVKNHKTCPYLVFLRKNCPVLLSEACLEKTEL
Gallus gallus LPNTLSRSTVYFEKKFLLYSRSYQEYFPKSFILSRLQGCQAGGRRLIETIFLSQNPLKEQQNQSLPQQKWRKKRLPKRYWQMREIFQKLVKNHEKCPYLVFLRKNCPVLLSEACLKKTEL
Xenopus laevis LYL-SISYKKGFSESFILNS---------------LDSTPSGSQKLVETIFLSNFLAEQNFDQPKRDENCRY-KLPKRYWKMKPHFQELIQNHKKFPYLVYLNKHCPVRSSMACSEKR--
Oryzias latipes LYGGRGMHGFCLNRKRRTAA---------------GPRRLQGQDLVRLVFFEGLPYLNGQERKPK--------KLPLRYFNMVPVFGRLLQRHRKCRYSSVLHRMCPVVELSRAAQG---
Oryzias melastigma
LYGGQGMQGFCLNRKKQTAA---------------GLRRLQGQDLVRLVFFQGLPYLDKQTRDPK--------KLRLRFFRMVPVFGELLQRHRKCPYTRVLQRMCPLVEESRAAPG---
Epinephelus coioides
LYGGRGMRGFLLNRKKKTPD---------------GCRRLQGTDLVRIVFFEGLAYLNGLERKPK--------KLPRRFFTMVPVFSRLLRQHRRCPYSRILQRMCPVVEDRNTQQE---
Takifugu rubripes
LYGGRGMRSFLLNRKKKTAE---------------GFRKIQGRDLIRIVFFEGVLYLNGLERKPK--------KLPRRFFNMVPLFSQLLRQHRRCPYSRLLQKTCPLVGIKDAGQA---
Danio rerio LYNGRGMKNFLLNRKLKGVG---------------GARRMQGEDLVRMIFLQ----SESNDSKPK--------KLPKRFFAMVPLFSRLLRQHRKCPYRLFLQRKC----AGNPDVK---
region
|--------------------region
v-II------------------|
|------------------------------------------------------------------------------------
610
620
630
640
650
660
670
680
690
700
710
720
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
|--------------------------------motif
QFP-----------------------
Homo sapiens REK-------------------------------------PQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRNTKKFISLG-KHAKLSLQELT
Mesocricetus auratus
-------------------------------------------------LNTTSPQRLMNLLRLHSSPWQVYGFLQACVGKLVPPGLWGSRHNQRRFFKNVKRFISLG-KYDKLSLQELT
Mus musculus --------------------------------------------------LNTSPPHLMDLLRLHSSPWQVYGFLRACLCKVVSASLWGTRHNERRFFKNLKKFISLG-KYGKLSLQELM
Rattus norvegicus
--------------------------------------------------MDTSPSHLTSLLRLHSSPWQVYGFLRACLRELVPAGLWGTRHNERRFLKNVKKFISLG-KYAKLSLQELM
Canis familiaris AHR--------------------------------GVGICPLERPVAAPQEQTDSTRLVQLLRQHSSPWQVYAFLRACLCWLVPTGLWGSRHNQRRFLRNVKKFISLG-KHAKLSLQELT
Bos taurus KCP--------------------------------GVGGCPSERPAAAPEGEANSGRLVQLLRQHSSPWQVYGLLRACLRRLVPAGLWGSRHNERRFLRNVKKLLSLG-KHGRLSQQELT
Coturnix japonica
TLQVALPGEAKVPKHTEHGKESTEGAALNSFHAPPSMPVCGQSERGEQHPAEGSDPLLGELLRQHSSHWQVYGFVRECLERVIPAELWGSSHNKCRFLKNVKAFISMG-KYDKLSLQQLM
Gallus gallus TLQAALPGEAKVHKHTEHGKESTEGTAPNSFLAPPSVLACGQPERGEQHPAEGSDPLLRELLRQHSSHWQVYGFVRECLERVIPAELWGSSHNKCRFFKNVKAFISMG-KYAKLSLQQLM
Xenopus laevis -----------------------------------SLQKNRIENDGKQLKHFTTKANLLSLLKQHSSIWQVYMFVRECLNNVVPDIMWGSSHNKCRFFRNVKSFLFFSGKFGKISLSELM
Oryzias latipes --------------------------------------------------------ELSSLIPQHCAPHRVYLFVRECLTAVVPEELWGSDHNRLQFFSRVRGFLKSG-KFERISVAELM
Oryzias melastigma
--------------------------------------------------------QPSSLIPLHCDPHRVYLFVRACLITVVPEELWGSDHNRLQFFTKVRCFLKNG-KFERVSVAELM
Epinephelus coioides
--------------------------------------------------------DLSSLLPRHCAPHRVYLFVRECLTAVIPPELWGSDHNRLHFFSRVRGFLRSG-KFERLSLAELM
Takifugu rubripes
--------------------------------------------------------ELSSFLPQHCGSHRVYLFVRECLLAVIPQELWGSEHNRLLYFARVRFFLRSG-KFERLSVAELM
Danio rerio --------------------------------------------------------DMESLLKSHSSPYRVYLFVRECLRHIIPHELWGCQENQLHFLSNVKNFLLLG-KFERLTLVQLM
region
|---------------------------------------region
---------------RID1-----------------------------------------------------------------------------------------------------
730
740
750
760
770
780
790
800
810
820
830
840
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
----------|
|--------------------motif T------------------------|
|-motif 1
Homo sapiens WKMSVRDCAWLRRSPGVGCVPAAEHRLREEILAKFLHWLMS-VYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPD
Mesocricetus auratus
WKMKVQDCRWLRSSPGNNCVPAAEHRTRERILAVFLFWLMD-AYVVELLRSFFYVTETTFQKNRLFFYRKSMWRRLQSIGVRHHLERVRLQELSQEEVRQRQEAWPAMPICRLRFIPKPS
Mus musculus WKMKVEDCHWLRSSPGKDRVPAAEHRLRERILATFLFWLMD-TYVVQLLRSFFYITESTFQKNRLFFYRKSVWSKLQSIGVRQHLERVRLRELSQEEVRHHQDTWLAMPICRLRFIPKPN
Rattus norvegicus
WRVKVEDCHWLRSSPEKDTVPAAEHRLRERILAMFLFWLMD-TYVVQLLRSFFYITETTFQKNRLFFYRKSVWSKLQSIGIRQQLERVQLRELSQEEVKHHQDTWLAMPICRLRFIPKLN
Canis familiaris WKMKVRDCTWLHGNPGACCVPAAEHRRREEILARFLVLVDGHIYVVKLLRSFFYVTETTFQKNRLFFYRKSVWSQLQSIGIRQLFNSVHLRELSEAEVRRHREARPALLTSRLRFLPKPS
Bos taurus WKMKVQDCAWLRASPGARCVPAAEHRQREAVLGRFLHWLMG-AYVVELLRSFFYVTETTFQKNRLFFFRKRIWSQLQRLGVRQHLDRVRLRELSEAEVRQHQEARPALLTSRLRFVPKPG
Coturnix japonica
WKMRVNDCVWLRLAKGNHSVPAYEHCYREEILAKFLYWLMD-SYVIELLKSFFYITETMFQKNTLFYYRKFIWGKLQNIGIRNHFAKVHLRALSSEEMDVIRQKKYFPIASRLRFIPKIN
Gallus gallus WKMRVNDCVWLRLAKGNHSVPAYEHCYREEILAKFLYWLMD-SYVIELLKSFFYITETMFQKNMLFYYRKFIWGKLQNIGIRDHFAKVHLRALSSEEMEVIRQKKYFPIASRLRFIPKMN
Xenopus laevis WSMRVEDCSWIRLQKSDHFVPASEHLLREKILAKFVFWLMD-TYVIQLLKSFFYVTETMFQKHRLLFYRKSVWKKLQNIGLRKHLEKVKLRSLSSDELENMQQWKNVPLVSRLRFIPKTN
Oryzias latipes WKIKVMDCDWLKLRRTAGRFPPSELAYRTRILSQFLTWLLD-GFVVGLVRACFYATESVGQKNAIRFYRQEVWSKLQDLAFRRHIAKGEMEELSPAQVASLP---KGTVISQLRFIPKTD
Oryzias melastigma
WKMKVMDCDWLKLRRTG-RFPPSELTYRTQILSLFLTWLLD-GFVVGLVQACFYATDSVGQKSTIRFYRPEVWNKLRDLAFRNHVAKGQMEELTPDQVASLP---KDAIISQLRFIPKAD
Epinephelus coioides
WKMKVNDCDWLKISKTG-RFPPSELSYRTQILGQFLAWLLD-GYVVSLVRACFYVTESVGQKNAVRFYRQEVWAKLQDLAFRGHLSKGQMEELTPAQVASLP---KTTVISRLRFIPKTD
Takifugu rubripes
WKIKVNNCDWLKISKTG-RVPPSELSYRTQILGQFLAWLLD-GFVVGLVRACFYATESMGQKNAIRFYRQEVWAKLQDLAFRSHISKGQMVELTPDQVAALP---KSTIISRLRFIPKTD
Danio rerio WRMKVQACHWLGPKKRQ---CASEHRYREWMLGQCMGWMLS-GFVVGLVRAQFYITESMGHKHTLRFYRGDVWSRLQDQAFRAHLCKGQWRPLSPSQALKVP---NSAVTSRIRFIPKTS
region
v-III-----------------------------------------| |---------------------region
v-IV----------------|
-------------------------------------|
850
860
870
880
890
900
910
920
930
940
950
960
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
||-2-|
|---------motif A------------|
Homo sapiens GLRPIVNMDYVV---GARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVR-AQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQ--NTYCVR
Mesocricetus auratus
GLRPIVNMSYM----GTRAFDKGKQAQHFTQCLKTLFSVLNYELTKHTNLLGASVLGLNDIYRTWRTFVLRVR-TLDPAPRMYFVKADVTGAYDAIPQDKLVEVIANMIRHPD-NSYCIH
Mus musculus GLRPIVNMSYSM---GTRALGRRKQAQHFTQRLKTLFSMLNYERTKHPHLMGSSVLGMNDIYRTWRAFVLRVR-ALDQTPRMYFVKADVTGAYDAIPQGKLVEVVANMIRHSE-STYCIR
Rattus norvegicus
GLRPIVNMSYGM---DTRAFGKKKQTQCFTQSLKTLFSVLNYERTKHPNLMGASVLGTSDSYRIWRTFVLRVR-ALDQTPRMYFVKADVTGAYDAIPQDKLVEIVANIIRRSE-SMYCIR
Canis familiaris GLRPIVNMDYIM---GARTFHRDKKVQHLTSQLKTLFSVLNYERARRPSLLGASMLGMDDIHRAWRTFVLRIR-AQNPAPQLYFVKVDVTGAYDALPQDRLVEVIANVIRPQE-STYCVR
Bos taurus GLRPIVNVGCVE---GAPAPPRDKKVQHLSSRVKTLFAVLNYERARRPGLLGASVLGMDDIHRAWRAFVLPLR-ARGPAPPLYFVKVDVVGAYDALPQDKLAEVIANVLQPQE-NTYCVR
Coturnix japonica
GLRPIVRLSRVVEGQKLSKESREKKIQRYNTQLKNLFSVLNYERTVNTSIIGSSVFGRDDIYRKWKEFVTKVFESGGEMPHYYFVKGDVSRAFDTIPHKKLVEVISQVLKPESQTVYGIR
Gallus gallus GLRPVVRLSRVVEGQKLSKESREKKIQRYNTQLKNLFSVLNYERTVNTSIIGSSVFGRDDIYRKWKEFVTKVFESGGEMPHFYFVKGDVSRAFDTIPHKKLVEVISQVLKPESQTVYGIR
Xenopus laevis GLRPISKISSTL-SSQQSKENQEKKIHHFSSQIRNLFSVLNYEWNRNCSLIGSSVFGMDDIYKKWKKFVLDFEKPQVEKLQFYFVKTDVKGAYDTIPHSKLDEVISKVINPNANEVYCIR
Oryzias latipes GMRPITRVIG-----------ADSNTRLHHKRIRDLMSMLQARVRSAPALLGSTVWGMTDIHKVLRSLAPAQK---DKPQPLYFVKVDVSGAYDSLPHDKLKEVITEALSPVQEEVFTVR
Oryzias melastigma
GMRPITRVIR-----------ADLHTRLHHWCIRDLMDLLQARVRSMPSLLGSTVWGLTDIHKVLSSLAPAQK---AKPQQLYFVKVDVSGAYESLPHDKLKQVVSEALSPIQEQVFAIR
Epinephelus coioides
GMRPITRVVG-----------ADAKTRVYRGRVRDLLDMLRACVRSTPSLLGSTVWGMTDIHRVLRSQAPAQK---DKPQPLYFVKVDVSGAYESLPHDKLIEVIGQALSPVQDELFTIR
Takifugu rubripes
GMRPITRVIG-----------ADAKTRLYQSHVRDLLDMLRACVCSTPSLLGSTVWGMTDIHKVLSSIAPAQK---EKPQPLYFVKMDVSGAYESLPHNKLIEVINQVLTPVLNEVFTIR
Danio rerio SMRPITRLSG-----------SRDTLQYFQSCVRVLQNVLSVCVREAPGPMGSTVWGWQDIHRRLQDFSPQQK---SSPRPLYFVKVDVSGAYDSLPHLKLVEVLKEVLGPFAEQSFFLR
region
970
980
990
1000
1010
1020
1030
1040
1050
1060
1070
1080
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
|-----------motif
B--------------|
Homo sapiens RYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQET--SPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIR-R
Mesocricetus auratus
QYAVVQRDRQGQIHKSFRRQVSTLSDLQPHMGQFLKHLQDSDTSALRNSVVIEQSLSLNEASSSLFDFFLRFVRNSVVKIGGRCYVQCQGIPQGSSLSTLLCSLCFGDMENKLFAEVQ-Q
Mus musculus QYAVVRRDSQGQVHKSFRRQVTTLSDLQPYMGQFLKHLQDSDASALRNSVVIEQSISMNESSSSLFDFFLHFLRHSVVKIGDRCYTQCQGIPQGSSLSTLLCSLCFGDMENKLFAEVQ-R
Rattus norvegicus
QYAVVQKDSQGQVHKSFRRQVSTLSDLQPYMGQFTKHLQDSDASALRNSVVIEQSISMNETGSSLLHFFLRFVRHSVVKIDGRFYVQCQGIPQGSSLSTLLCSLCFGDMENKLFAEVQ-Q
Canis familiaris HYAVVQRTARGHVRKAFKRHVSTFADLQPYMRQFVERLQET--SLLRDAVVIEQSSSLNEAGSSLFHLFLRLVHNHVVRIGGKSYIQCQGVPQGSILSTLLCSLCYGDMERRLFPGIE-Q
Bos taurus HCAMVR-TARGRMRKSFKRHVSTFSDFQPYLRQLVEHLQAM--GSLRDAVVIEQSCSLNEPGSSLFNLFLHLVRSHVIRIGGRSYIQCQGIPQGSILSTLLCSFCYGDMENKLFPGVQ-Q
Coturnix japonica
WYAVIMITPTGKARKLYKRHVSTFEDFIPDMKQFVSKLQER--TSLRNAIVVEQCLTFNENSSTLFSFFLQMLHNNILEIGHRYYMQCSGIPQGSILSTLLCSLCYGDMENKLLPGIQ-K
Gallus gallus WYAVIMITPTGKARKLYKRHVSTFEDFIPDMKQFVSKLQER--TSLRNAIVVEQCLTFNENSSTLFTFFLQMLHNNILEIGHRYYIQCSGIPQGSILSTLLCSLCYGDMENKLLCGIQ-K
Xenopus laevis RYATVSVDPTGRIIKSFKRHVSELADVLPNMKQFVSNQQEK--NLLRNTILVEQNLLLNESSVKLLAVFQQIIRSHILRIKDRYYMQCCGIPQGSMLSTILCSLCYGDMENAMLGGIQ-K
Oryzias latipes HYAKIWADSHEGLKKAFARQVDFSDGSMGSTSMKGFVMSLQKSSKVHHAVLVEQAFGSNLRGKDALQFFTQMLTGSVVQHGKKTYRQCRGIPQGSVVSSLLCCLCYGHMENVLFRDIK-N
Oryzias melastigma
RYAKIWRDSHEGVKKTFTKQVDFSDGDLGSSTMKNFTMALQQISNAHHSVLVEQAFTSNIQGKDAVQVFMQMLTGSIVQYENKTYRQCRGIPQGSVVSSLLCCLCYGHMERVLFRDLSKN
Epinephelus coioides
HYAKIWADSHEGLKKSFVRQADFLEDNMGSTNMKGFVTSLQKRGKVHHAILVEQHFSSDLHGREALQFFTQMLTGSVVQFGKKTYRQCRGIPQGSVVSSLLCCLCYGHMENVLFKDITEK
Takifugu rubripes
RFAKIWADSHEGLKKAFIRQADFLEANMGSINMKQFLTSLQKKGKLHHSVLVEQIFSSDLEGKDALQFFTQILKGSVIQFGKKTYRQCQGVPQGSAVSSVLCCLCYGHMENVLFKDIINK
Danio rerio QYSSVWSDPTRGLRKRFCTKAEMSEP----LNMKGFVVDEQVSGRLHDAILVER-HSSEVRGGDVFQFFQKMLCSYVIHYDQQMFRQVCGIPQGSSVSSLLCNLCYGHMEKALLKDIA-K
region
1090
1100
1110
1120
1130
1140
1150
1160
1170
1180
1190
1200
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
|----motif C----||---------motif
D----------|
|---motif E---||----------------------------motif E-I--
Homo sapiens DGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLR
Mesocricetus auratus
DGLLLRFVDDFLLVTPHLVQAEAFLRALVRGIPEYGCMINLQKTVVNFPVDAGTLDGTAPHQLPAHCLFPWCGLLLDTQTLEVLCDYTGYARTSIKASLTFQRTFKAGRNMRQKLLAVLR
Mus musculus DGLLLRFVDDFLLVTPHLDQAKTFLSTLVHGVPEYGCMINLQKTVVNFPVEPGTLGGAAPYQLPAHCLFPWCGLLLDTQTLEVFCDYSGYAQTSIKTSLTFQSVFKAGKTMRNKLLSVLR
Rattus norvegicus
DGLLLRFVDDFLLVTPHLAHAKAFLSTLVHGVPEYGCMINLQKTVVNFPVETGALGGAAPHQLPAHCLFPWCGLLLDTRTLEVFCDYSGYGRTSIKMSLTFQGVSRAGKTMRYKLLSVLR
Canis familiaris DGVLLRLVDDFLLVTPHLTQAQAFLRTLVKGVPEYGCRANLQKTAVNFPVEDGALGSAAPLQLPAHCLFPWCGLLLDTRTLEVSCDYSSYAHTSIRASLTFSQGAKPGRNMRRKLLAVLR
Bos taurus DGVLLRLVDDFLLVTPHLTRARDFLRTLVRGVPEYGCQVNLRKTVVNFPVEPGALGGAAPLQLPAHCLFPWCGLLLDTRTLEVHGDHSSYARTSIRASLTFTQGFKPGRNMRRKLLAVLQ
Coturnix japonica
DGVLIRLIDDFLLVTPHLMQARTFLRTIAAGIPEYGFVINAKKTVVNFPVDD-IPGCSKFKQLPDCRLISWCGLLLDVQTLEVYCDYSSYAFTSIRSSLSFNSSRIAGKNMKCKLTAVLK
Gallus gallus DGVLIRLIDDFLLVTPHLMQARTFLRTIAAGIPEYGFLINAKKTVVNFPVDD-IPGCSKFKHLPDCRLISWCGLLLDVQTLEVYCDYSSYAFTSIRSSLSFNSSRIAGKNMKCKLTAVLK
Xenopus laevis NGVLMRLIDDFLLVTPHLDQAKTFLRTLAEGIPQYGCSISPQKTVVNFPVDD-IPECSEVEQLPSHCLFRWCGLLLDTQTLDVYYDYSSYACTSIRSSMTFCHSSAAGKYMKQKLIRVLR
Oryzias latipes KGCLMRLVDDFLLITPDRNQAQSFLSILLAGVPQYGVVANPQKVVVNFQGSEGGGAFPDIRVLPPHCLFPWCGLLLDTRSLDVCKDYSSYAGLSLRYSLTLGSAHSAGQQMRRKLMSILR
Oryzias melastigma
SGCLMRLVDDFLLITPDLNQAHTFLRIFLAGVPQYGVVANPQKVVVNFQPSEFGDAFTDVRVLPSHCLFPWCGLLLDTQSLDVYKDYSSYAGLSLRYSLTLGSTHLPGQQMRRKLMSILR
Epinephelus coioides
KRCLMRLVDDFLLITPDLQEAQSFLRILLAGVPQYGLVVNPQKVAVNFQMLGSVGSCPGIRVLPPHCLFPWCGLLLDTHSLDVYKDYSSYAGLSLRYSLTLGSFHSAGQQMRRKLMAILR
Takifugu rubripes
KSCLMRLVDDFLLITPNLHDAQTFLKILLAGVPQYGLVVNPQKVVVNFEDYGSTDSCPGLRVLPLRCLFPWCGLLLDTHTLDIYKDYSSYADLSLRYSLTLGSCHSAGHQMKRKLMGILR
Danio rerio GGCLMRLIDDFLLITPHLSKATEFLTTLLSGVPDYGCQINPQKVAVNFPVCVS-WVNSGVSVLPSSCLFPWCGLMIHTHTLDVYKDYSRYDGLSLRYSLTLGSAHSPSTVMK-KLLSVLS
region
|----region
v-V-----|
|-------------
1210
1220
1230
1240
1250
1260
1270
1280
1290
1300 1310 1320
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif
-----------------------------------------| |-------motif E-II-----|
|------------motif E-III-----------|
Homo sapiens LKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTA
Mesocricetus auratus
LKCHSLFLDLQMNSLQTVCINVYKIFLLQAYRFHACALQLPFDQHVRKNPAFFLSIISNIASCCYSILKVKNAGMTLKAKGASGSFPPEAARWLCYQAFLLKLAGHSVTYKCLLGPLRTA
Mus musculus LKCHGLFLDLQVNSLQTVCINIYKIFLLQAYRFHACVIQLPFDQRVRKNLTFFLGIISSQASCCYAILKVKNPGMTLKAS---GSFPPEAAHWLCYQAFLLKLAAHSVIYKCLLGPLRTA
Rattus norvegicus
LKCHGLFLDLQVNSLQTVCINIYKIFLLQAYRFHACVIRLPFGQHVRKNHAFFLGIISNLASCCYAILKVKNPGVSLRAKGAPGSFPPEATRWLCYQAFLLKLAAHSVTYKCLLGPLRTA
Canis familiaris LKCCALFLDLQVNGIHTVYMNVYKIFLLQAYRFHACVLQLPFNQPVRKNPSFFLRVIADTASCCYSLLKARNAGLSLGAKGASGLFPSEAARWLCLHAFLLKLAHHSGTYRCLLGALQAA
Bos taurus LKCHGLFLDLQVNSLQTVFTNVYKIFLLQAYRFHACVLQLPFSQPVRSSPAFFLQVIADTASRGYALLKARNAGASLGARGAAGLFPSEAAQWLCLHAFLLKLARHRVTYSRLLGALRTA
Coturnix japonica
LKCHPLLLDLKINSLKTVLINIYKIFLLQAYRFHACVLQLPFNQKVRNNPYFFLRIISDTASCCYYILKAKNPGVSLGSKDASGMFPSEAAEWLCYHAFIVKLSNHKVIYKCLLKPLKFY
Gallus gallus LKCHPLLLDLKINSLQTVLINIYKIFLLQAYRFHACVLQLPFNQKVRNNPDFFLRIISDTASCCYFILKAKNPGVSLGSKDASGMFPFEAAEWLCYHAFIVKLSNHKVIYKCLLKPLKVY
Xenopus laevis LKCHSLFLDLKVNSLRTVCINTYKIFLLQAYRFHACVVQLPFGQRVMNNPPFFLTVISDMAPCFYTTFKAKNKDLTRGYKDVSCQFNFEAVQWLSYQAFLTKLHNHKVLYKCLIGPLQNC
Oryzias latipes IKCHPLFLDLKTNSLESAYKNIHKLVLLQACRFHVCVQSLPFAQTVAKNPTYFQQMIWDMAHYANALIRRSNTGLVLGDGAQKGSVQYEAVELLFCLAFLRVLSKHRPVYKDLLPRLHKW
Oryzias melastigma
LKCHPLFLDLKMNSHESVYKNIYKLVLLHACRFHVCAQSLPFSQTVAKNPSYFLQMIWDMVRYANTLIRRCNRGLVLGDKAQTGSVQFEAVKLLFCLCFQLVLSKHRPVYRDLLPHLDKC
Epinephelus coioides
LKCHALFLDLKTNSLEAVYKNIYKLVLLHARRFHVCVQSLPFGQTVAKNPMFFLQMILDMAEYANQLIRLSNKGQILGSKAQSGVVQYEAVELLFCLSFLLVMSQHRPLYKDLLPHLHKR
Takifugu rubripes
LKCHALFLDLKTNSLEAIYKNIYKLLLLHALRFHVCAQSLPFGQSVAKNPAYFLLMIWDMVEYTNYLIRLSNNGLISGSTSQTGSVQYEAVELLFCLSFLLVLSKHRRLYKDLLLHLHKR
Danio rerio IKSTDIFLDLRLNSVEAVYRSLYKLILLQALRFHACVRSLPLGQSVNRNPSFFLKMIWRMTRVTNKLLTHINKGLPVCSVDSGGVLQSEAVQLLFCLAFETLFRRFRSVYHCLIPALHKR
region
------------region
v-VI----------------------------------|
|-------------------------region v-VII----------------------
1330
1340
1350
....|....|....|....|....|....|...
motif
|E-IV|
Homo sapiens QTQLSRKLPGTTLTALEAAANPALPSDFKTILD
Mesocricetus auratus
QKQLCRKLPRATMAILETAADPALSTDFQTILD
Mus musculus QKLLCRKLPEATMTILKAAADPALSTDFQTILD
Rattus norvegicus
QKQLCRKLPEATMTLLKTAADPALSTDFQTILD
Canis familiaris KAHLSRQLPRGTLAALEAAADPSLTADFKTILD
Bos taurus RARLHRQLPGPTRAALEAAADPALTADFKTILD
Coturnix japonica
KMHLFGKIPKDTMELLKTVTEPSLCQDFKTILD
Gallus gallus KMHLFGKIPRDTMELLKTVTEPSLCQDFKTILD
Xenopus laevis KMQLSRRLSQDTIELLKSVTDSSLHKDFSCIMD
Oryzias latipes KRRLERLLGDLRLARVRQAANPRALLDFLAMQM
Oryzias melastigma
KRHMERLLGDLRLARVQQASDPRALLDFL--QM
Epinephelus coioides
KRSLERRLGDLRLARVRQAAKPRTPNDFLAIQM
Takifugu rubripes
KRRLEQCLGDLRLARVRQAANPRNPLDFLAIKT
Danio rerio KRALQRELCGITLARVRQASSPRIPLDFS-MRV
region
--------------------------------|