10 20
30
40 50
60
70 80
90
100
110
120
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
|-NL--| |---TruB I---|
Homo sapiens
MADAEVII-LPKKHKKKKERK---SLPEEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFDKLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVE
Rattus norvegicus
MADAEAAMTFPKKHKKKKERK---PLPEADVAEIQHAEDFLIKPESKAAQLDTSQWPLLLKNFDRLNVRTTHYTPIPCGSNPLKREIGEYVRTGFINLDKPSNPSSHEVVAWIRRILRVE
Mus musculus
MADAEVI-TFPKKHKKKKDRK---PLQEDDVAEIQHAEEFLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVE
Bos taurus
MADAEVLI-LPKKHKKKKERK---SLPEEAVAEIQHAEEFLIKPESRVAQLDTSQWPLLLKNFDKLNVRTTHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVE
Gallus gallus
MADGDG---SSVKKRRKKDKR---SLPDEDVADIQHTEEFLIKPESRVAQLDTSQWPLLLKNFDKLNVLTTHYTPLPSGANPLKREISDYVRSGFINLDKPSNPSSHEVVAWIRRILRVE
Danio rerio
MADTES-----KKEKKRKSKK----ISDEEVGDIQESGDFLIKPESKVASLDTSQWPLLLKNFDKLNIRTAHYTPLPHGSNPLKRGIHDYVRSGFINLDKPANPSSHEVVAWIKRILRVE
Drosophila melanogaster MADVEV-----RKEKKKKKIKEEP-LDGDDIGTLQKQGNFQIKPSSKIAELDTSQWPLLLKNFDKLNIRSNHYTPLAHGSSPLNRDIKEYMKTGFINLDKPSNPSSHEVVAWIKKILKVE
Anopheles gambiae
MEVDI-PTSPIKKEKKKKKIKQEPDTEIENLGEIQKSGDFQLKPSSAIASLDTSKWPLLLKNFDRLNVRTNHYTPLPFGSSPLNRKINDYVSAGFINLDKPSNPSSHEVVAWIKRILKVN
Aedes aegypti
MSDYEMGSPTIKKEKKKKKIKQEPGAEIENLGEIQKSGNFQIQPSAAIAKLDTSQWPLLLKNFDRLNVRTNHYTPLPFGSSPLNRKIKDYVTSGFINLDKPSNPSSHEVVAWIKKILKVD
Culex pipiens quinquefasciatus MG-----SPHIKKEKKKKKIKQEPGVEVENLGEIQKSGDFQIKPSEAIAKLETSKWPLLLKNFDRLNVRTNHYTPLPFGSSPLNRKIKDYVTSGFINLDKPSNPSSHEVVAWIKKILKVE
Caenorhabditis elegans MG---------KKDKRSK-------LEGDDLAEAQQKGSFQLPSSNETAKLDASQWPLLLKNYDKLNVRTNHYTPHVEGVSPLKRDIKNYISSGFFNLDKPSNPSSHEVVSWIKRILRCE
Schizosaccharomyces pombe MTD-----------------------------THPGVDFMIKPEATSASKIDTAEWPLLLKNFDKLLVRTGHYTPIPCGNNPLKRPIAEYVSSGVINLDKPANPSSHEVVAWVKKILRVE
Saccharomyces cerevisiae MSK----------------------------------EDFVIKPEAAGASTDTSEWPLLLKNFDKLLVRSGHYTPIPAGSSPLKRDLKSYISSGVINLDKPSNPSSHEVVAWIKRILRCE
Kluyveromyces lactis MS-----------------------------------DEFVIKPESVSPSSNTSEWPLLLKDYDKLLVRSGHYTPIPAGASPLKRDLKSYISSGVINLDKPSNPSSHEVVAWIKRILRCE
Ashbya gossypii
MS-----------------------------------EEHMIKPENVAPSADTSEWPLLLKNYDKLLVRSGHYTPIPAGASPLKRDLKSYVSSGVINLDKPSNPSSHEVVAWIKRILRCE
Lodderomyces elongisporus MSK----------------------------------EDFQIKPEAVTPANNTSDWPLLLKNYDKLLVRSGHYTPIPAGSSPNNRDLKSYVSSGVINLDKPSNPSSHEVVAWIKRILRVE
Pichia stipitis
MS-----------------------------------DEYFIKPEAVSPSNDTSEWPLLLKNFDKLLVRSGHYTPIPSGSSPLKRDIKSYISSGVINLDKPSNPSSHEVVAWIKRILRSE
Pichia guilliermondii MAPHDAMRIF------------LNTIIVVFIFPVAMSDEYMIKPESIAPSNDTSEWPLLLKNFDKLLVRSGHYTPIPAGSSPLKRDLKSYVSSGVINLDKPSNPSSHEVVAWIKRILRTE
Zygosaccharomyces rouxii MSK-----------------------------------DFVIKPDTSGPTPDTAEWPLLLKDYDKLLMRSGHYTPIPAGSSPGKRDIKSYVNSGVINLDKPSNPSSHEVVAWIKRILRCE
Aspergillus fumigatus MAV----------------------------SVTKEEMDYTIKPEAGASNISTEDWPLLLKNYDKLMVRTGHFTPIPAGCSPLKRDLKSYISSGVINLDKPSNPSSHEVVAWMKRILRAE
Aspergillus clavatus MAV----------------------------ALAKEEMDYTIKPEAGASNISTEEWPLLLKNYDKLLVRTGHFTPIPAGCSPLKRDLKSYVSSGVINLDKPSNPSSHEVVAWMKRILRAE
Aspergillus nidulans M---------------------------------AKEVDYTIKPEATASNINTEDWPLLLKNYDKLMVRTGHFTPIPAGSSPLKRDLKSYINSGVINLDKPSNPSSHEVVAWMKRILRAE
Chaetomium globosum M----------------------SDSKALVKKGEDNEVEYMIKPQTLVPTLNTSDWPLLLKNYDKMLVRSGHFTPIPNGSSPYKRDIKSYVSSGVINLDKPSNPSSHEVVAWLKRMLRVE
Magnaporthe grisea MGG-------------------NKDALALARRDEEVDEEFSIKPEQVTPALDTSSWPLLLKNYDKLHIRTGHFTPIPNGSTPLRRDIKSYISSGVINLDKPSNPSSHEVVAWIKRILRCE
Neurospora crassa
MG---------------------------------AETEHVIKPQATEPAVDTSEWPLLLKNYSNLLVRTGHFTPIPAGSSPSKRDIKSYVSSGVINLDKPSNPSSHEVVAWIKRMLRVE
Botryotinia fuckeliana MALV--------------------------STKKEQEVDYTIKPEALTPAVDTSSWPLLLKNYNNLLVRTGHFTPIPNGCTPLKRDLKSYISSGVINLDKPSNPSSHEVVAWVKRMLRVE
Pyrenophora tritici-repentis MALV-----------------------------QTDPDAYVIKPAAAAPAIDTSDWPLLLKNYSDLLVRTSHYTPIPNGCAPLSRDLKSYISSGVINLDKPSNPSSHEVVSWIKRMLRVE
Neosartorya fischeri MAV----------------------------SVAKEEMDYTIKPEAGASNISTEEWPLLLKNYDKLMVRTGHFTPIPAGCSPLKRDLKSYISSGVINLDKPSNPSSHEVVAWMKRILRAE
Coccidioides immitis MAA------------------------------SKSDMDFSIKPEAATPPIPTSEWPLLLKNYDKLLVRTGHFTPIPAGCTPLKRDLKSYISSGVINLDKPSNPSSHEVVAWMKRILRVE
Dictyostelium discoideum MTT--------------------DKKSKSKSSEKSTQEVEQVIKPEKTPILDTSKWPLLLKNYDQLSVRTGHYTPIPNGHSPLKRPIKEYVKYGIINLDKPSNPSSHEVVAWIRTILRVT
Arabidopsis thaliana MAEVDI-------------SHSKKKKQDKTENDAADTGDYMIKPQSFTPAIDTSQWPILLKNYDRLNVRTGHYTPISAGHSPLKRPLQEYIRYGVINLDKPANPSSHEVVAWIKRILRVE
Chlamydomonas reinhardtii MSV----------------------------GEAQQRTDFLIQPEKTVPKLDTSKWPLLLKNYDKLNVRTGHYTPIPAGSTPLKRPLKEYLSYGCINLDKPANPSSHEVVAWVKRMLRVE
Cryptosporidium parvum SSM---------------------GKRKELEEMSDGKIETVIKPESKSQPIDTSNWPLLLKNYSKLNVRTGHYTPLPYGNSPLNRNLADYLSYGIINLDKPANPSSHEVVAWIKKILRCE
Euglena gracilis
MAKA----------------------------QWENDFSIPTESGEKGAALDSSEWPLLLKNYDKLNVRSAHYTPIPQGHTPLKRPIKAYLQYGCLNLDKPSNPSSHEVVSWLKRILKVE
Methanocaldococcus jannaschii MILLE------------------------------------------------KTQEKKINDKEELIVKEEVETNWDYGCNPYERKIEDLIKYGVVVVDKPRGPTSHEVSTWVKKILNLD
130
140
150
160
170
180
190
200
210
220
230
240
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
|---TruB II--|
Homo sapiens
KTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEG-GTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGL
Rattus norvegicus
KTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGVVRLHNAIEG-TAQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESRVVEYDPERRLGVFWVSCEAGTYIRTLCVHLGL
Mus musculus
KTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEG-GTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGL
Bos taurus
KTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEG-GTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGL
Gallus gallus
KTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIES-EAQLARAIETLTGALFQRPPLIAAVKRQLRVRTIYESKLVEYDPERRLGIFWVSCEAGTYIRTLCVHLGL
Danio rerio
KTGHSGTLDPKVTGCLIVYVERATRLVKSQQSAGKEYVGIVRLHNALEN-EHQLARALECLTGALFQRPPLIAAVKRQLRVRTIYESKLIEYDPERRLGIFWVSCEAGTYIRTLCVHLGL
Drosophila melanogaster KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAIFKLHGAVES-VAKVRQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDETRNMGVFWVSCEAGSYIRTMCVHLGL
Anopheles gambiae
KTGHSGTLDPKVTGCLIVCINRATRLVKSQQSAGKEYVAVFKLHSAVEK-IAKVTQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYNDQRNIGVFWVSCEAGSYIRTMCVHLGL
Aedes aegypti
KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAVFKLHSAVES-VAKVNQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDDQRNMGVFWVSCEAGSYIRTMCVHLGL
Culex pipiens quinquefasciatus KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAVFKLHSAVES-VAKVNQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDDQRNMGVFWVSCEAGSYIRTMCVHLGL
Caenorhabditis elegans KTGHSGTLDPKVSGCLIVCIDRTTRLAKSQQGAGKEYICIFKLHEEVED-DRKVKQALEKLTGALFQRPPLISAVKRQLRIRTVYENKFIEYDPAQQMGIFNCICESGTYVRTICVHLGL
Schizosaccharomyces pombe KTGHSGTLDPKVTGCLIICNDRATRLVKSQQSAGKEYVCVLRLHDSVEG-ERNVASAIETLTGALFQRPPLISAVKRQLRIRSIYESKLIEFDNERNLAVFWASCEAGTYMRTLCVHLGL
Saccharomyces cerevisiae KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDALKD-EKDLGRSLENLTGALFQRPPLISAVKRQLRVRTIYESNLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGM
Kluyveromyces lactis KTGHSGTLDPKVTGCLIVCVDRATRLVKSQQGAGKEYVCIVRLHDALKD-EKELGRGLENLTGALFQRPPLISAVKRQLRVRTIYDSNLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGM
Ashbya gossypii
KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDALKD-EKDLGRELENLTGALFQRPPLISAVKRQLRVRTIYDSKLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGM
Lodderomyces elongisporus KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDQLEE-PKELNRALENLTGALFQRPPLISAVKRQLRVRTVYDSKLIEFDNKRGLGVFWASCEAGTYMRTLCVHLGM
Pichia stipitis
KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHEELKD-AKDLGRSLENLTGALFQRPPLISAVKRQLRVRTIYDSNLIEFDNKRGLGVFWASCEAGTYMRTLCVHLGM
Pichia guilliermondii KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDELKD-AKDMGRSLENLTGALFQRPPLISAVKRQLRVRTIYDSNLIEFDNKRGLGVFWASCEAGTYMRTLCVHLGM
Zygosaccharomyces rouxii KTGHSGTLDPKVTGCLIVCVDRATRLVKSQQGAGKEYVCIVRLHDALKD-EKDLGRSLESLTGALFQRPPLISAVKRQLRVRTIYDSNLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGM
Aspergillus fumigatus KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFKRALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL
Aspergillus clavatus KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFKRALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNERHLGVFWVSCEAGTYIRTLCVHLGL
Aspergillus nidulans KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFKRALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNERHLGVFWVSCEAGTYIRTLCVHLGL
Chaetomium globosum KTGHSGTLDPKVTGCLIVCIDRATRLVKAQQGAGKEYVAVVRFHDTIPGGEPAFAKALETLTGALFQRPPLISAVKRQLRIRTIHESKLIEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL
Magnaporthe grisea KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKVPGGEPEFARALETLTGALFQRPPLISAVKRQLRIRTIHESKLIEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL
Neurospora crassa
KTGHSGTLDPKVTGCLIVCVDRATRLVKAQQGAGKEYVCVIRFHDSVPGGEAAFASALETLTGALFQRPPLISAVKRQLRIRSIYESKLIEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL
Botryotinia fuckeliana KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKLPGGEAQFARALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL
Pyrenophora tritici-repentis KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKLPGGEAQFARALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNERQLGVFWVSCEAGTYIRTLCVHLGL
Neosartorya fischeri KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFKRALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL
Coccidioides immitis KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFARALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL
Dictyostelium discoideum KTGHSGTLDPKVTGCLIVCIERATRLVKSQQGAGKEYIGIVRLHGAIEG-TTELSKAVDTLTGALFQRPPQKSAVKKRLRVRTIHNSKLLEFDPERNLGLIWVDCEAGTYIRTLCVHIGL
Arabidopsis thaliana KTGHSGTLDPKVTGNLIVCIDRATRLVKSQQGAGKEYVCVARLHSAVP-DVAKVARALESLTGAVFQRPPLISAVKRQLRIRTIYESKLLEYDADRHLVVFWVSCEAGTYIRTMCVHLGL
Chlamydomonas reinhardtii KTGHSGTLDPKVTGNLIVCIDRATRLVKAQQAAGKEYVCIARFHGKVEGGTAAVNKALETLTGALFQRPPLISAVKRQLRVRTIYQAKLYEYDEERHLAVFWISCEAGTYVRTLCVHLGL
Cryptosporidium parvum KTGHSGTLDPKVTGCLLVCLNRATRLVKSQQSAGKEYVCIVRFHSSVGG-KSAVSRCLETLTGALFQRPPVISAVKRQLRVRSIYDSKLLDYDEKRNLAVFWAKCEAGTYIRTMCVHMGL
Euglena gracilis
KTGHAGTLDPKVTGSLLICIERATRLVKSQQNAGKEYVGVLRLHDALKD-EAQLLKALEDLTGAVFQRPPVVAAVKRTLRIRTIYESKLLDFDNDRHLAVFWISCEAGTYVRTLCVHLGF
Methanocaldococcus jannaschii KAGHGGTLDPKVTGVLPVALERATKTIPMWHIPPKEYVCLMHLHRDASE--EDILRVFKEFTGRIYQRPPLKAAVKRRLRIRKIHELELLDKDGKD--VLFRVKCQSGTYIRKLCEDIGE
250
260
270
280
290
300
310
320
330
340
350
360
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
|---------------------------------------PUA domain-------
Homo sapiens
LLGVGGQMQELRRVRSGVMSEK--DHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRY---------EDGIEVNQEIVVITTKGEAIC
Rattus norvegicus
LLGVGGQMQELRRVRSGVVGER--DHMVTMHDVLDAQYLYDHHRDESYLRRVVFPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRY---------EDGIEVNQEVVVITTKGEAVC
Mus musculus
LLGVGGQMQELRRVRSGVMSEK--DHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRY---------EDGIEVNQEIVVITTKGEAIC
Bos taurus
LLGVGGQMQELRRVRSGVMSEK--DHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRY---------EDGIEVNQEIVVITTKGEAIC
Gallus gallus
LLGVGGQMQELRRVRSGILGEM--DNMVTMHDVLDAQWQYDNNKDDSYLRRVILPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRY---------EDGIELKQEIVVITTKGEAIC
Danio rerio
LLGVGGQMQELRRVRSGVLGEK--DNLVTMHDVLDAQWQFDHNKDETYLRRVIFPLEKLLISHKRIVMKDSAVNAICYGAKIMLPGVLRY---------EDGIEVNQDIVVITTKGEAIC
Drosophila melanogaster VLGVGGQMLELRRVRSGIQSER--DGMVTMHDVLDAMWLYENHKDESMLRRVIKPLEGLLVNHKRIIMKDSSVNAVCYGAKITLPGVLRY---------EDGIEIDQEIVICTTKGEAIC
Anopheles gambiae
VLGVGGQMLELRRVRSGIQSEK--DGMVTMHDVLDAQYLYENHKDESMLRRVIKPLEGLLVGHKRIIMKDSSVNAVCYGAKILLPGVLRY---------EDGIEIDQEIVIVTTKGEAIA
Aedes aegypti
VTGVGGQMLELRRVRSGIQSEK--DGMVTMHDVLDAQYLYDNHKDETMLRRVIKPLEGLLVGHKRIIMKDSSVNAVCYGAKIMLPGVLRY---------EDGIEMDQEIVIVTTKGEAVA
Culex pipiens quinquefasciatus VTGVGGQMLELRRVRSGIQSEK--DGMVTMHDVLDAQYLYENHKDESMLRRVIKPLEGLLIGHKRIIMKDSSVNAVCYGAKIMIPGVLRY---------EDGIEVDQEIVIVTTKGEAIA
Caenorhabditis elegans ILGCGGQMQELRRNRSGICDEN--ENMVTMHDVLDAQYLLDTQKDESYMRHIVRPLEALLTQHKRVVVKDSCINAICYGAKILIPGILRY---------DDDIEVGKEIVIMSTKGEAIC
Schizosaccharomyces pombe LLGVGGHMQELRRVRSGCLSEN--DDIVTMHDVLDAQWIYDNTRDESYLRRVIRPLESLLVGYKRIVVKDSAVNAICYGAKLMIPGLLRY---------EAGIEVNEEIVLITTKGEAIA
Saccharomyces cerevisiae LLGVGGHMQELRRVRSGALSEN--DNMVTLHDVMDAQWVYDNTRDESYLRSIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRY---------EEGIELYDEIVLITTKGEAIA
Kluyveromyces lactis LLGVGGHMQELRRVRSGALSEN--DNLVTLHDVMDAQWVYDNTRDESYLRKIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRY---------EEGIELYDEVVLITTKGEAIA
Ashbya gossypii
LLGVGGHMQELRRVRSGALDEN--DNMVTLHDVLDAQWVYDNTRDESYLRKIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRY---------EEGIELYDEVVLITTKGEAIA
Lodderomyces elongisporus LLGVGGHMQELRRVRSGAMSES--DNLVTLHDVLDAQYVYDNTRDESYLRKIIQPLETLLVGYKRLVVKDSAVNSVCYGAKLMLPGLLRY---------ESGIELYDEVVLITTKGEAIA
Pichia stipitis
LLGVGGHMQELRRVRSGALGEN--DNLVTLHDVLDAQYVYDNTRDESYLRKIIQPLETLLVGYKRIVVKDSAVNSVCYGAKLMIPGLLRY---------EEGIELYDEVVLMTTKGEAIA
Pichia guilliermondii LLGVGGHMQELRRVRSGALAEN--DNLVTLHDVLDAQYVYDNTRDESYLRKIIQPLETLLVGYKRIVVKDSAVNSVCYGAKLMIPGLLRY---------EEGIELYDEVVLITTKGEAIA
Zygosaccharomyces rouxii LLGVGGHMQELRRVRSGALSEN--DNLVTLHDILDAQWVYDNTRDESYLRRVIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRY---------EDGIELYDEVVLITTKGEAIA
Aspergillus fumigatus LLGVGAHMQELRRVRSGAMDEN--NGLVTLHDVLDAQWMYDNQRDESYLRRVIQPLESLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRF---------EAGIEVNEEVVLMTTKGEAIA
Aspergillus clavatus LLGVGAHMQELRRVRSGAMDEN--NGLVTLHDVLDAQWMYDNQRDESYLRRVISPLESLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRF---------EAGIDVNEEVVLMTTKGEAIA
Aspergillus nidulans LLGVGAHMQELRRVRSGAMSEN--EGMVTLHDVLDAQWLYDNQRDESYLRKVIKPLESLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRFGQKSLTWGLEAGIELGEEVVLMTTKGEAIA
Chaetomium globosum LLGVGAHMQELRRVRSGVMSED-NGSLVTLHDVLDAQWQYDNGGDESYLRKVIQPLETLLCTYKRLVVKDSAVNAVCYGAKLMLPGLLRY---------DAGIDAHEEVVLMTTKGEAIA
Magnaporthe grisea MLGVGAHMQELRRVRSGAMDET--KDLHTLHDVLDAQWLMDNTRDESYLRKVIQPLETLLTTYKRLVVKDSAVNAVCYGAKLMLPGLLRY---------EADIELHEEVVLMTTKGEAIA
Neurospora crassa
LLGVGAHMQELRRVRSGIMSED-NGSMVTLHDVLDAQWQFDNGGDETALRKVIQPLETLLTTYKRIVVKDSAVNAVCYGAKLMLPGLLRF---------EKGIETHEEVVLMTTKGEAIA
Botryotinia fuckeliana LLGVGAHMQELRRVRSGAMDET--KDMVTLHDVLDAQWMQDNARDEAYLRKVIQPLETLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRY---------EADIEVHEEVVLMTTKGEAIA
Pyrenophora tritici-repentis LLGVGAHMQELRRVRSGAMDET--KDLVTLHDVLDAQWLHDNNRDEAYLRKVIAPLESLLMSYKRIVVKDSSVNAICYGAKLMLPGLLRF---------EKGIEIHEEVVLMTTKGEAIA
Neosartorya fischeri LLGVGAHMQELRRVRSGAMDEN--NGLVTLHDVLDAQWMYDNQRDESYLRRVIRPLESLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRF---------EAGIDVNEEVVLMTTKGEAIA
Coccidioides immitis LLGVGAHMQELRRVRSGAMDEQ--DGMVTLHDVLDAQWMMDNNRDESYLRRVVRPLETLLTTYKRVVVKDSAVNAVCYGAKLMIPGLLRF---------EAGIEVHEEVVLMTTKGEAIA
Dictyostelium discoideum LMGVGGHMQELRRVRSGIMSEK--KGQVTMHDVKDAQYEYDNSKDESYLRRVIQPLEAILTNYKRIVVKDSAINAICYGAKLMIPGLLRY---------EQDIESNEEVVLITTKGEAIA
Arabidopsis thaliana LLGVGGHMQELRRVRSGILGEN--NNMVTMHDVMDAQFVYDNSRDESYLRRVIMPLEMILTSYKRLVVKDSAVNAICYGAKLMIPGLLRF---------ENDIDVGTEVVLMTTKGEAIA
Chlamydomonas reinhardtii LLGVGGHMQELRRVRSGIMGEAPSNNMVTMHDVLDAQWLYDNFKDESYLRRAVMPLEVLLTSFKRLVVKDSAVNAICYGAKLMIPGLLRF---------ESGVEVDDEVVLMTTKGEAVA
Cryptosporidium parvum LLGVGAHMQELRRVRSGCLSEN--DNMVTMHDILDAQYMLDNYRDESYLRRIISPLELLLTDLPRIVVKDSCVNAICYGAKLMIPGVLRF---------DNGIDVGTEVVMMTTKGEAIA
Euglena gracilis
VLGTAGHMAELRRTRTGHLGEN--DGMVTMHDVLDAMHLYDQEGDESYLRRTVMPCELLLTAYKRVVVKDTAVNAICYGAKLMIPGLLRF---------ENGIEVNEVIVLMTTKGEAIA
Methanocaldococcus jannaschii ALGTSAHMQELRRTKSGCFEEK---DAVYLQDLLDAYVFWKEDGDEEELRRVIKPMEYGLRHLKKVVVKDSAVDAICHGADVYVRGIAKL---------SKGIGKGETVLVETLKGEAVA
370
380
390
400
410
420
430
440
450
460
470
480
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
-------------------------|
Homo sapiens
MAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKLMIKQGLLDKHGKPTDSTPATWKQEY-------VDYSESAKKEVVAEVVKAPQVVAEAAKTA------------
Rattus norvegicus
VAIALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKQLIKQGLLDKHGRPTDGTPASWTRDY-------VDYSDSSKKATAAEATPGPGVTADAASIV------------
Mus musculus
MAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKMMIKQGLLDKHGKPTDNTPATWKQDY-------IDYSDSGKNTLVTEAVQAPQLAAEAVNVI------------
Bos taurus
MAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKLMIKQGLLDKHGKPTDSTPATWMQEY-------VDYSNSAKKDVPPKAVKATPVVAEVVKTP------------
Gallus gallus
LAIALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKMMIQKGLLDKHGKPNECTPDSWKKEY-------VDYRESSKK----EAAKVPQAVSEVERAP------------
Danio rerio
TAVALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKMMIQKGLLDKHGKPNNSTPSDWKEGY-------VDYSTTKVK----KGG---------EASA------------
Drosophila melanogaster LAIALMTTATMASCDHGVVAKIKRVIMERDTYPRKWGLGPKASAKKALIAAGKLDKFGRPNENTPKEWLTGY-------VDYNAKKPAAQEVSPTNGSSEP-------S-----------
Anopheles gambiae
LGIALMTTATMAGCDHGVVAKIKRVIMERDTYPRKWGLGPKASMKKQLIASGKLDKYGKPNENTPKDWLNSY-------SDFNR---SAKQANGNGTSADD---EFAGG-----------
Aedes aegypti
LAIALMTTATMASCDHGVCAKIKRVIMERDTYPRKWGLGPKASMKKQLIASGKLDKYGKPNDKTPKEWLTGY-------VDFNKPAAPGKDTNGNGAAAAEGEDEFAGG-----------
Culex pipiens quinquefasciatus LGVALMTTATMASCDHGVCAKIKRVIMERDLYPRKWGLGPKASMKKQLIASGKLDKFGKPNDKTPKEWLTGY-------TDYNK----AKPSNGNQVAAEE-DDEVVGG-----------
Caenorhabditis elegans IAIAQMNTSTIASVDHGVVAKSKRVIMERDVYGRKWGLGPVASKKKQMVKDGLLDKFGKPNDTTPKSWAKEY-------VQTST------------------------------------
Schizosaccharomyces pombe VGIAQMSTVELSTCDHGVVAKVKRCIMERDVYPRRWGLGPQSMKKKTLKKEGKLDKYGRPNENTPADWSKSY-------IDYS--DPNAEVAKPAPVVAPAAPTVEAEVNGVEDS-----
Saccharomyces cerevisiae VAIAQMSTVDLASCDHGVVASVKRCIMERDLYPRRWGLGPVAQKKKQMKADGKLDKYGRVNENTPEQWKKEY-------VPLDNAEQSTSSSQETKETEEEPKKAKEDS-----------
Kluyveromyces lactis VAIAQMSTVDLATCDHGVVAKVKRCIMERDLYPRRWGLGPIAQKKKQMKADGKLDKYGRANENTPETWKKTY-------VSLENAEPTTAPASKSEE-KPLIKEVE--------------
Ashbya gossypii
VAIAQMSTVDLATCDHGVVAKVKRCIMERDLYPRRWGLGPVAQKKKQLKADGKLDKYGRVNENTPEDWKKTY-------VSHE-PSADAAAEVAPVKSEPLIEEVS--------------
Lodderomyces elongisporus IGIAQMTTVDLQSCDHGVVAKVKRCIMERDTYPRRWGLGPVAQKKKQLKADGKLDKYGRVNDETPETWKKEY-------KDLD--EAPAPAIPESKLVAPAPQ-LP--------------
Pichia stipitis
IGIAQMTTVDLQGCDHGVVAKVKRCIMERDTYPRRWGLGPVAQKKKQMKADGKLDKFGRANENTPETWKQEY-------KDHD--EEPAPAVPASKLVAPEVQ-LP--------------
Pichia guilliermondii IGIAQMTTVDLQSCDHGIVAKVKRCIMERDTYPRRWGLGPVAQKKKQLKADGKLDKYGRTNENTPESWKAEY-------KDHD--ETPAPPVPEAKLAAPEIQ-LP--------------
Zygosaccharomyces rouxii VAIAQMSTVDLATCDHGVVAKVKRCIMERDLYPRRWGLGPVAQKKKQMKVDGKLDKYGRVNESTPEDWKKSY-------VPLDNAEAPAARESAPKESAPLVQEVD--------------
Aspergillus fumigatus IGIAQMSTVELSTCDHGVVAKVKRCIMERDLYPRRWGLGPVALEKKKLKSAGKLDKYGRANEDTPAKWKTEY-------KDYSAPEEASA-HAASESTAKEDVAAALTT--------EQD
Aspergillus clavatus IGIAQMSTVELSTCDHGVVAKVKRCIMERDLYPRRWGMGPVALEKKKLKSAGKLDKYGRTNEATPAKWKTEY-------KDYNAPEDAAA-QPATETNGTEEAAAAPAA--------EQA
Aspergillus nidulans IGIAQMSTVELSTCDHGVVAKVKRCIMERDLYPRRWGLGPVALEKKKLKSSGKLDKYGRANEATPAKWKSEY-------KDYSAPDGDSS-QQAVDVVAKEEASP------------KEE
Chaetomium globosum IGIAQMSTVEMSTCDHGVVAKVKRCIMERDLYPRRWGLGPVAMEKKKLKADGKLDKFGRTNEATPAKWQQGY-------TDYGAA---DAAAAAAASAAAAPLEA--------------A
Magnaporthe grisea IGIAQMSTVEISSCDHGVVAKVKRCIMERDLYPRRWGLGPVAGEKKKLKADGKLDKFGRPNEATPSRWTQNY-------KDYSAPAPDAAAPAAD--EAAAATESP-------------A
Neurospora crassa
IGIAQMNGVEMLSCDHGVVAKVKRCIMERDLYPRRWGLGPVALEKKKLKSDGKLDKFGRPNAETPAKWTEGY-------KDFSAAAESEAAAAAAPAAEAAKVEI--------------A
Botryotinia fuckeliana LGIAQMSTVELSSCDHGVVAKVKRCIMERDLYPRRWGMGPVAIEKKKMKTEGKLDKYGRPNEATPAKWNNEY-------KDFNAPPEDGAIAIHPKPEVVASAVAP-------------A
Pyrenophora tritici-repentis LAYAQMSAVEMSSCDHGVVAKIKRVIMERDLYPRRWGMGPVATEKKKMKEAGTLDKFGRPNDKTPAKWNTEY-------KDFNRNDVDGASAPVAQTTSTAEVLAAPAI--------PAT
Neosartorya fischeri IGIAQMSTVELSTCDHGVVAKVKRCIMERDLYPRRWGLGPVALEKKKLKSAGKLDKYGRANEDTPAKWKTEY-------KDYSAPEEASA-QAAPGSTAKEDVAAALTT--------EQD
Coccidioides immitis LGIAQMSTVEMSTCDHGVVAKVKRCIMERDLYPRRWGMGPVALEKKKMKADGKLDKFGRPNASTPAKWQAEY-------KDYSASADAAAPQPATEATPATPAQAPAAS--------PEE
Dictyostelium discoideum IGIAQMTTASMATCDHGVVATIKRVIMDRDVYPVRWGLGPKAKVKKEMIKDGKLDKFGKPNEKTPSDWTNTY-------TYYTGQVATTTTTSPVESMNVDTPKKATASVA--------V
Arabidopsis thaliana VGIAEMTTSVMATCDHGVVAKIKRVVMDRDTYPRKWGLGPRASMKKKLIADGKLDKHGKPNEKTPVEWSRNV-------VLPTGGDAIIAGAAAAPEEIKADAENGEAGEARKRKHDDSS
Chlamydomonas reinhardtii VGIAQMTTGVMATVDHGCVAKIKRVIMERDTYPRRWGLGPYAQIKKKLITEGKLDKHGRPNENTPKEYLR---------SLP---DFVANGGASAAAAAPAAAT----------------
Cryptosporidium parvum IGVAQMTTAVIASVDHGVVAIIKRVIMERDTYDMRWGHGPRASEKKKLILGGKLDKHGKPNEQTPESWLKYEGYIPKLTGDHDDQNDEGKDITGSGLESESNSNIESSS-SKKRKEKKET
Euglena gracilis
LGIALMTTADMGTCDHGIVAKIKRVVMDRDTYPRRWGLGPVALKKKEMIERGHLDKHGRRTEATPNSWW--Y-------VDYSG------CGSNEEAMNREGNK--SLGPP--------P
Methanocaldococcus jannaschii VGKALMNTKEILNADKGVAVDVERVYMDRGTYPRMWKRKK--------------------------------------------------------------------------------
490
500
510
520
530
540
550
560
570
580
590
600
....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
|NL|
Homo sapiens
--------------------------------KRKRESESESDETPPAAPQLI-------KKEKKKSKKDKK------AKAGLESGAEPGDGDSD--TTKKKKKKKKAKEVELVSE----
Rattus norvegicus
--------------------------------KRKRDSDSDADEATPTTTPRV-------KKEKKK-KKEK----------ADGGEEAAEDGDGD--ATRKKKKKK-ARAAEELSG----
Mus musculus
--------------------------------KRKRDSESES-DETPTVPQLK-------EKKKKKDKKPK---------TVLESGGETGDGDND--TTKKKKKKK-VKVVEEMSE----
Bos taurus
--------------------------------KRKRESESE--DTSPAAPQVV-------KKEKKKKKKEK-------AKAAAEK---PGAGDSD--STKKKKKKK--IKAEMVSE----
Gallus gallus
--------------------------------KRKRESESENEAVSPPPSPATPPPEELSKKEKKKKKKEKK------AKEAAESGEEQ-VEVISESSAKKKKKKKKQKEVEESSE----
Danio rerio
--------------------------------KRKRD-ESGSEGEAAAAAQDTSKTEEESKKEKKKKKKEKK------QKLAEEAAAEAPAEEETEVTESAKKKKKKKK-----------
Drosophila melanogaster --------------------------------KRKLST-SSVEETAAAAVSEET-PSKDKKKKKKKHKGDEE----------APEAAEEEA-EPVEKEKKKKKKKDKDRDRDEAQE----
Anopheles gambiae
--------------------------------KRKLSIGENVES-----AATIG-DGEEKKKKKKKQKKDAEDGDGEAVGAEGQPMDQAEGDEEMKKEKKKKKKKDKNVSVDEVAE----
Aedes aegypti
--------------------------------KRKLSVGSAADQSMETSAMEVD-AGEKKKKKKKKHKKDDE--APEAP--ETPEAVEVEATEEVSETK--KKKKKKDKKQEEEAE----
Culex pipiens quinquefasciatus --------------------------------KRKLSIGSAADNSMDTSAIDAG-EGKEKKKKKKKQKQDEE--APEEAAAEATEPAEADATEETSESKKEKKKKKKDKKQQEEAE----
Caenorhabditis elegans --------------------------------KKEVKKEETPDEE---------EEEAPKKKSKKSKKQESSDSDSD-------------------------------------------
Schizosaccharomyces pombe --------------------------------KKRKSVESSEKDED----EAAKKEEKRRKKEAKKEKKEKKEKK--------------EKKE-------KKKKSE--------------
Saccharomyces cerevisiae -------LIKEVETEKEEVKED----------------DSKKEKKEKKDKKEKKEKKEKKDKKEKKEKKEKKRKS--------------EDGD--SEE-KKSKKSKK-------------
Kluyveromyces lactis ----KKEVEQKEESKEESKTPE-----------------------EKKDKKEKKEKKDKKEKKEKKEKKEKKRKA--------------DDDE--SSE-KKKKKSKK-------------
Ashbya gossypii
----KKDAKTEVEVPAEKKQDD-------------EEKKEKKEKKEKSEKKEKKEKKEKSEKSEKKEKKEKKRKA--------------DDEN--ASEEKKKKKSKK-------------
Lodderomyces elongisporus ----KKTLIEEVEVST------------------------VEVDGDKKEKKEKKDKKDKKDKKDKKDKKEKKRKA--------------EDDEGESSKSEKKKKSKKD------------
Pichia stipitis
----KKTLIEEVASEEASEA--------------------EEKKEDKKEKKEKKEKKEKKDKKEKKDKKDKKRKA--------------EDGE---EKAEKKKKAKK-------------
Pichia guilliermondii ----KKLIEEVETKSSLDDDM------------------EEESKKEKKEKKEKKEKKEKKEKKEKKEKKEKKRKS--------------EDGE---TESGKKKKSKKE------------
Zygosaccharomyces rouxii ----KKDEEEKKEEKKEEKKEEKEEKKEEAEESDDEEKSDKKSKKEKKDKKEKKDKKEKKEKKEKKEKKEKKRKA--------------DDDE--DGE-SKKKKSKK-------------
Aspergillus fumigatus EAPSSPQSKMDVDETKEE-------------KKRKRHEG----------ETAEERAERKRKKKEKKEKKERRKSKQEKE---------DSDDSD--------------------------
Aspergillus clavatus EAPSSPQSKMDVDEDKDE-------------KKRKRHEG----------ETPEERAERKRKKKEKKEKKERRKSKQEKD---------DSDDSD--------------------------
Aspergillus nidulans PSLEANESKMDIDDAQDDE----------DKKKRKRHEG----------ETPEERAERKRKKKEKKEKKERRKSKQEKD---------DSDDSD--------------------------
Chaetomium globosum SPQKQIEAAPATEEKADE-----------ESKKRKKHEG----------ETAEEKAERKRLKKEKKEKKEKKKGKEAA----------DESD----------------------------
Magnaporthe grisea KALPAPEAEPEAEADDGK-------------KRKSKHEG----------ETAEEKAERKRRKKEKKEKRASKAAAE------------EDSD----------------------------
Neurospora crassa
ERPKPEEKAEKSEEAEEAG----------DSKKRKKHDG----------ETAEEKAERKKQKKEKKEKKEKKEKKSKKGG--------DESD----------------------------
Botryotinia fuckeliana LAPVDGNAAEDDEEKSD--------------KKRKRHDG----------ETAEEKAERKRKKKEKKAKRESKKS----AG--------GSSDSE--------------------------
Pyrenophora tritici-repentis GLTSTEEAEAEAEAGAADA--------DSKKSKKRKSRG------DGEEEADEDKAERKKKKKEEKAAKKAAKKDKRKSKG------GDDSDSD--------------------------
Neosartorya fischeri EAPSSPQSKMDVDETKEE-------------KKRKRHEG----------ETAEERAERKRKKKEKKEKKERRKS-KQEKE--------DSGDSD--------------------------
Coccidioides immitis ASSPAP------EADKED------------AKKRKRHDG----------ETPEEREERKRRKKEKKEEKEKRKQEKKEKKERRKSKQADSSDSE--------------------------
Dictyostelium discoideum KAEVESSEDEKPVPKKEKKD-----------KKEKKKDSS--------DDESEEEKSSKKDKKEKKEKKEKKEKKSSKDDSDDESSKKEKKDKKRKKSSDKDSDSEKESSDKKDKKDKKE
Arabidopsis thaliana DSPAPVTTKKSKTKEVEGEEAEEK---VKSSKKKKKKDK-----------EEEKEEEAGSEKKEKKKKKDKKEEVIEEVASPKSEKKKKKKSKDTEAAVDAEDESAAEKSEKKKKKKDKK
Chlamydomonas reinhardtii -------------------------------PVEIKEEG----------------------KKEKKVRRWGKS-----------------------------------------------
Cryptosporidium parvum NDEESSSSFSSKN----------KKEKNKRKSTEPLSENGSSSSSSDSSSSNSSSDDEKSKSKGKKSSKDKSKKKKKHSR--------ISED----------------------------
Euglena gracilis
KVRIEELAYAEAAKKRER------------------------------EAAGEDEKDAKKAKKEKKEKKEKKEKK-------------EKAEKTA-------------------------
Methanocaldococcus jannaschii ------------------------------------------------------------------------------------------------------------------------
610
....|....|.
Homo sapiens
-----------
Rattus norvegicus
-----------
Mus musculus
-----------
Bos taurus
-----------
Gallus gallus
-----------
Danio rerio
-----------
Drosophila melanogaster -----------
Anopheles gambiae
-----------
Aedes aegypti
-----------
Culex pipiens quinquefasciatus -----------
Caenorhabditis elegans -----------
Schizosaccharomyces pombe -----------
Saccharomyces cerevisiae -----------
Kluyveromyces lactis -----------
Ashbya gossypii
-----------
Lodderomyces elongisporus -----------
Pichia stipitis
-----------
Pichia guilliermondii -----------
Zygosaccharomyces rouxii -----------
Aspergillus fumigatus -----------
Aspergillus clavatus -----------
Aspergillus nidulans -----------
Chaetomium globosum -----------
Magnaporthe grisea -----------
Neurospora crassa
-----------
Botryotinia fuckeliana -----------
Pyrenophora tritici-repentis -----------
Neosartorya fischeri -----------
Coccidioides immitis -----------
Dictyostelium discoideum KKKSKN-----
Arabidopsis thaliana KKNKDSEDDEE
Chlamydomonas reinhardtii -----------
Cryptosporidium parvum -----------
Euglena gracilis
-----------
Methanocaldococcus jannaschii -----------