10 20 30 40 50 60 70 80 90 100 110 120

....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|

Saccharomyces cerevisiae -----------------------------------------------------------------------------------------------MPKVILESHSKPTDSVFLQPWIKAL

Kluyveromyces lactis -----------------------------------------------------------------------------------------------MPNVVLSSRLTNNDSVFLQEWIKPS

Candida albicans --------------------------------------------------------------------------------MFRSVSLSSLIPFLIIVSIAMQRPENDVPMIMQSSWLVNE

Candida dubliniensis ----------------------------------------------------------------------------------------------------MQKSENDVPMIMQSSWLVNE

Candida glabrata -----------------------------------------------------------------------------------------------MPPFIPKSRSNAVESVYLHGWVRDM

Debaryomyces hansenii ----------------------------------------------------------------------------------------------------MNVN-IKYPLVLHDNWLLES

Ashbya gossypii -----------------------------------------------------------------------------------------------MPKVVLASRAHKADSIFLREWLVDA

Lodderomyces elongisporus MDEYSHKQLLSLYGHDVRKYIEAHEQLEAEFEELRIHDDFMILRNEADKRDYRQLVLRLDPKILELFALSGQSEDAAVGGKSKRNFIGIQGFSKVKDCTLTTRELESLVKKHDHSWLLKD

Pichia guilliermondii ----------------------------------------------------------------------------------------------------MYEPTYEWEIVLQTTWIQKA

Pichia stipitis ----------------------------------------------------------------------------------------------------MNYNNDKFPLVFLQSWLWES

130 140 150 160 170 180 190 200 210 220 230 240

....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|

Saccharomyces cerevisiae IE----DNSEHDQYHPSGHVIPSLTKQDLALPHMSPTILTNPCHFAKITKFYNVCD-YKVYASIRDSSHQILVEFSQE-CVSNFERT--------HNCRITSETTNCLMIIGDADLVYVT

Kluyveromyces lactis VRPYYLKNEKTKFWPEQRELVTDLLEHDIIESAFQTALNPAPQRFVRIVKFHRVND-YTVYATIRDSTALILCYFTVD-CVLDYETI--------NNDRITLNTLNTLFVIGNVTLQFWN

Candida albicans VIKSINSNGQ---------YINALIKKDFQ-PTVLP-----VSFILRILKFTATTDSKDITAVLADSTHKIFAIFLFFPAIVDFENK--------YHHRMTYNTRSCLIRIHKANLKFMD

Candida dubliniensis VIKSINSNGQ---------YINSLIKKDFQ-PTVLP-----VSFVLRILKFTATTDSKDITAVLADSTHKIFAIFLFSPAIVDFENK--------YHHRMTYNTRSSVIRIHKANLRFMD

Candida glabrata LL----ESKTSQNIA----VIPRVDPDEASIPLLSRRIYANRRHFVKITKFFQVHN-YSVYASVKDSQHQILSQFTPK-CVSEFESR--------NRSRITSDTVNTLFMIGDAKLGIMV

Debaryomyces hansenii ITGQINKNVK---------YTNSLIKKDFISPSSIS-----KTPILRILRFLKTTKSSDLTAILSDSTHTVIAIFPFDPAIINFEIR--------YKHRITYHTPNSLILIKQANLRFVN

Ashbya gossypii VVPALERSGACAPWAGVECFIPALPPATATLS-LEPTVIQNPKRFLRIVRFTRVHD-FAVCAVARDAGCCILVEFTPH-CVSNFERR--------YHQRITSSTVNSLFVIGNTSLLFYA

Lodderomyces elongisporus ILLLIKRHPR---------LMEPMINRKFKPNNGKS-----TPFYLRILEFGERSSNGAINVVMGDQTHKVCCIFPRKTVLRHMSRGKLMMGMFGLDNGFVAHAIYNFVLVKRARLRFEE

Pichia guilliermondii VTRCLQHHLR---------FSATDVEHHFIHPSHKKHVR--ETPIIRVYRYLKTTDQLALTAIVSDTRHLIFAKFPYDPTIIKFEQL--------YRQRLTYMTAGCLFVIKQAKLRFAK

Pichia stipitis VEKCIDPSRR---------YTSSLIKKNFVDETPRK-----ASPIVRISKFIKVTDNKDLTVILSDSTNLMFAIFPFKPTIVNFEDK--------YKQRITFHTQNILIHIKKANLRFIE

250 260 270 280 290 300 310 320 330 340

....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|

Saccharomyces cerevisiae NSRAMSHF----KICLSNISSKEIVPVLNVNQATIFDIDQVGSLSTFPFVYKYL---------------------------------------------------

Kluyveromyces lactis HRECKLWFNQ-DFPGLR------MVPVLKIEKARMFDRDQISSNVQFEWVYDTLHG-------------------------------------------------

Candida albicans KSTVKKCYGR-KSDGGLAIAVLEVLEFDIFFKDQYSFINSIENRLKYVYDDVEYNQLCG---------KKKHKP----EYEDLMCDI------------------

Candida dubliniensis QSTVNKCYNM-KTNGNLAIAVLEILEFDIFLKDQYSFITSIENRLKYVYEDTRYDQLCR---------EKMHRP----EYDDLMCDM------------------

Candida glabrata VDELRHYFGE-KIVSLFNGLDMPYIPYLIINQAFILDYDQVEAFKMTPFVYQYI---------------------------------------------------

Debaryomyces hansenii NVELTTEWGI-TIEDEIDVAVLEVLDLEIFQRDQIMLGVNIENNLQLIYYDKSYLNLCGKSRQRDSLGEKEIKEVISQSYDDVVSI-------------------

Ashbya gossypii RSDAAAAF---EVPALMNGSS--TLPVLRVGDCAIFDQDQVESHRRFPLVQEHPRFVQSLDMAMQGSVLSRYT--------------------------------

Lodderomyces elongisporus RSYIRDHFNLPKISSKLKYCVIEILDFEYVASVKAALQRKLPNFCSKDVKQNYNKALENAKQTDLESDEEFEADEEPLPDAELDFNKHDCKYVYNIDLYVRYCRQ

Pichia guilliermondii PGEVAKDFDF-SISPNIQIVILEIDDFTVFSRDQAILPHEALSKVNMIYYDREYYDLCGRDCYIPEYSKDVEKQVS-DDYGDVVSV-------------------

Pichia stipitis RKDYP-LYEI-PAMG-LSMVVLEVLDLEIFQRDQIMLSNKVESTLKFLHNESNYESLFG--RKWNNAEENNDRE----DYDDVVSF-------------------