The Telomerase Database is a Web-based tool for the study of structure, function and evolution of telomerase ribonucleoprotein. The objective of this database is to serve the research community by providing a comprehensive compilation of information known about telomerase enzyme and its substrate, telomeres. The collection of information includes sequences, alignments, secondary and tertiary structures, mutations known to cause human telomerase-deficiency diseases, and current telomerase researchers.
Illustration of the vertebrate telomerase ribonucleoprotein complexed with its substrate, telomeric DNA (blue). Telomerase consists of the telomerase reverse transcriptase (TERT, in yellow and pink), telomerase RNA (TR, in green) and dyskerin protein complex. The TERT protein contains the TEN, RID1, RID2 and RT domains. The TR structure contains the P1b that defines tempalte boundary, the template that anneal to the 3'-end of telomeric DNA, the pseudoknot, CR4-CR5 domain that include P6 and P6.1, and the 3'-box H/ACA stem loop bound by the dyskerin protein complex (dyskerin, Nop10, NHP2, and Gar1). The TRF1 and TRF2 proteins bind to double stranded telomeric DNA, while the POT1 protein binds to the single stranded region.
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